Applied Electrospray Mass Spectrometry

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Overview

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

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Editorial Reviews

From The Critics
Focusing on the application of mass spectrometric analysis to pharmaceutical, peptide, and protein chemistry, this volume contains 11 articles written by contributors from industry and academia. The volume begins with a historical review of the ESI technique including its principles and instrumentation, a description of nanospray development, and applications in macromolecules. Chapters that follow address applications of small molecules; peptides and proteins; noncovalent complexes; special topics in protein folding and unfolding; and clinical and biomedical applications. A number of chapters should be of great interest to scientists in the pharmaceutical industries. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780824706180
  • Publisher: Taylor & Francis
  • Publication date: 8/28/1996
  • Series: Practical Spectroscopy Series
  • Pages: 446
  • Product dimensions: 6.00 (w) x 9.00 (h) x 1.13 (d)

Table of Contents

Preface
Contributors
1 Electrospray Ionization Mass Spectrometry: History, Theory, and Instrumentation 1
2 Nanospray Electrospray Ionization Development: LC/MS, CE/MS Application 105
3 Characterization of Pharmaceuticals and Natural Products by Electrospray Ionization Mass Spectrometry 149
4 Electrospray Mass Spectrometry Applications in Combinatorial Chemistry 187
5 Electrospray Mass Spectrometry in Contemporary Drug Metabolism and Pharmacokinetics 211
6 Electrospray Mass Spectrometry of Peptides and Proteins: Methodologies and Applications 251
7 Structural Analysis of Glycoproteins by Electrospray Ionization Mass Spectrometry 283
8 Advanced Mass Spectrometric Approaches for Rapid and Quantitative Proteomics 307
9 Detection of Noncovalent Complexes by Electrospray Ionization Mass Spectrometry 361
10 Application of Hydrogen Exchange and Electrospray Ionization Mass Spectrometry in Studies of Protein Structure and Dynamics 389
11 Microelectrospray Analysis Combined with Microdialysis Sampling of Neuropeptides and Drugs 411
Index 431
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