Applied Electrospray Mass Spectrometry

Applied Electrospray Mass Spectrometry

by Birendra N. Pramanik
     
 

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical

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Overview

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

Product Details

ISBN-13:
9780824706180
Publisher:
Taylor & Francis
Publication date:
08/28/1996
Series:
Practical Spectroscopy Series
Pages:
446
Product dimensions:
6.00(w) x 9.00(h) x 1.13(d)

Table of Contents

Preface
Contributors
1Electrospray Ionization Mass Spectrometry: History, Theory, and Instrumentation1
2Nanospray Electrospray Ionization Development: LC/MS, CE/MS Application105
3Characterization of Pharmaceuticals and Natural Products by Electrospray Ionization Mass Spectrometry149
4Electrospray Mass Spectrometry Applications in Combinatorial Chemistry187
5Electrospray Mass Spectrometry in Contemporary Drug Metabolism and Pharmacokinetics211
6Electrospray Mass Spectrometry of Peptides and Proteins: Methodologies and Applications251
7Structural Analysis of Glycoproteins by Electrospray Ionization Mass Spectrometry283
8Advanced Mass Spectrometric Approaches for Rapid and Quantitative Proteomics307
9Detection of Noncovalent Complexes by Electrospray Ionization Mass Spectrometry361
10Application of Hydrogen Exchange and Electrospray Ionization Mass Spectrometry in Studies of Protein Structure and Dynamics389
11Microelectrospray Analysis Combined with Microdialysis Sampling of Neuropeptides and Drugs411
Index431

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