Applied Survival Analysis: Regression Modeling of Time to Event Data / Edition 2

Applied Survival Analysis: Regression Modeling of Time to Event Data / Edition 2

by David W. Hosmer Jr., Stanley Lemeshow, Susanne May
     
 

ISBN-10: 0471754994

ISBN-13: 9780471754992

Pub. Date: 01/18/2008

Publisher: Wiley

This book provides a comprehensive, self-contained introduction to regression modeling used in the analysis of time-to-event data in epidemiological, biostatistical, and other health-related research. Unlike other texts on the subject, it focuses almost exclusively on practical applications rather than mathematical theory and it offers clear, accessible

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Overview

This book provides a comprehensive, self-contained introduction to regression modeling used in the analysis of time-to-event data in epidemiological, biostatistical, and other health-related research. Unlike other texts on the subject, it focuses almost exclusively on practical applications rather than mathematical theory and it offers clear, accessible presentations of modern modeling techniques supplemented with real-world examples and case studies.

Product Details

ISBN-13:
9780471754992
Publisher:
Wiley
Publication date:
01/18/2008
Series:
Wiley Series in Probability and Statistics Series, #618
Edition description:
New Edition
Pages:
416
Product dimensions:
6.26(w) x 9.33(h) x 1.10(d)

Table of Contents

Preface.

1. Introduction to Regression Modeling of Survival Data.

1.1 Introduction.

1.2 Typical Censoring Mechanisms.

1.3 Example Data Sets.

Exercises.

2. Descriptive Methods for Survival Data.

2.1 Introduction.

2.2 Estimating the Survival Function.

2.3 Using the Estimated Survival Function.

2.4 Comparison of Survival Functions.

2.5 Other Functions of Survival Time and Their Estimators.

Exercises.

3. Regression Models for Survival Data.

3.1 Introduction.

3.2 Semi-Parametric Regression Models.

3.3 Fitting the Proportional Hazards Regression Model.

3.4 Fitting the Proportional Hazards Model with Tied Survival Times.

3.5 Estimating the Survival Function of the Proportional Hazards Regression Model.

Exercises.

4. Interpretation of a Fitted Proportional Hazards Regression Model.

4.1 Introduction.

4.2 Nominal Scale Covariate.

4.3 Continuous Scale Covariate.

4.4 Multiple-Covariate Models.

4.5 Interpreting and Using the Estimated Covariate-Adjusted Survival Function.

Exercises.

5. Model Development.

5.1 Introduction.

5.2 Purposeful Selection of Covariates.

5.2.1 Methods to examine the scale of continuous covariates in the log hazard.

5.2.2 An example of purposeful selection of covariates.

5.3 Stepwise, Best-Subsets and Multivariable Fractional Polynomial Methods of Selecting Covariates.

5.3.1 Stepwise selection of covariates.

5.3.2 Best subsets selection of covariates.

5.3.3 Selecting covariates and checking their scale using multivariable fractional polynomials.

5.4 Numerical Problems.

Exercises.

6. Assessment of Model Adequacy.

6.1 Introduction.

6.2 Residuals.

6.3 Assessing the Proportional Hazards Assumption.

6.4 Identification of Influential and Poorly Fit Subjects.

6.5 Assessing Overall Goodness-of-Fit.

6.6 Interpreting and Presenting Results From the Final Model.

Exercises.

7. Extensions of the Proportional Hazards Model.

7.1 Introduction.

7.2 The Stratified Proportional Hazards Model.

7.3 Time-Varying Covariates.

7.4 Truncated, Left Censored and Interval Censored Data.

Exercises.

8. Parametric Regression Models.

8.1 Introduction.

8.2 The Exponential Regression Model.

8.3 The Weibull Regression Model.

8.4 The Log-Logistic Regression Model.

8.5 Other Parametric Regression Models.

Exercises.

9. Other Models and Topics.

9.1 Introduction.

9.2 Recurrent Event Models.

9.3 Frailty Models.

9.4 Nested Case-Control Studies.

9.5 Additive Models.

9.6 Competing Risk Models.

9.7 Sample Size and Power.

9.8 Missing Data.

Exercises.

Appendix 1: The Delta Method.

Appendix 2: An Introduction to the Counting Process Approach to Survival Analysis.

Appendix 3: Percentiles for Computation of the Hall and Wellner Confidence Band.

References.

Index.

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