Overview

Providing must-have knowledge for the pharmaceutical industry and process chemists in industry, this ready reference offers solutions for saving time and money and supplying -- in a sustainable way -- valuable products. Application-oriented and well structured, each chapter presents successful strategies for the latest modern drugs, showing how to provide very fast bulk quantities of drug candidates. Throughout, the text illustrates how all the key factors are interwoven and dependent on one another in creating ...
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The Art of Process Chemistry

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Overview

Providing must-have knowledge for the pharmaceutical industry and process chemists in industry, this ready reference offers solutions for saving time and money and supplying -- in a sustainable way -- valuable products. Application-oriented and well structured, each chapter presents successful strategies for the latest modern drugs, showing how to provide very fast bulk quantities of drug candidates. Throughout, the text illustrates how all the key factors are interwoven and dependent on one another in creating optimized methods for optimal products.
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Editorial Reviews

From the Publisher
"The book will be of great value to students looking to move into a career in process research; the enthusiasm and commitment of the authors comes over in the text, and the attention to detail and emphasis on mechanistic evaluation is a lesson to all. Academics will find much material that can be used in teaching . . . so in conclusion, this is an outstanding book which discusses the art of process research and developing process understanding." (Organic Process, Research & Development Journal, 17 December 2010)
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Product Details

  • ISBN-13: 9783527633586
  • Publisher: Wiley
  • Publication date: 12/1/2010
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 298
  • Product dimensions: 0.59 (w) x 9.84 (h) x 5.91 (d)
  • File size: 11 MB
  • Note: This product may take a few minutes to download.

Meet the Author

Nobuyoshi Yasuda received his bachelor from Tokyo Institute of Technology under the direction of Professor Teruaki Mukaiyama and Professor Hisashi Takei and his mater degree from the same university under the direction of Professor Hisashi Takei. After working at Fujisawa Pharmaceutical Company, Japan as a Medicinal Chemist, he received Ph. D. from Tokyo Institute of Technology in 1987. After spend one year as a postdoctoral fellow under Professor Robert M. Williams at Colorado State University from 1988 to 1989, he joined in Process Chemistry, Merck Research Laboratories in 1990. He has over 60 publications and over 50 patents.
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Table of Contents

Preface

Efavirenz?, a Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI), and a Previous Structurally Related Development Candidate

CCR5 Receptor Antagonist

5a-Reductase Inhibitors -
The Finasteride Story

Rizatriptan (Maxalt?): A 5-HT1D Receptor Agonist

SERM: Selective Estrogen Receptor Modulator

HIV Integrase Inhibitor: Raltegravir

Cyclopentane-Based NK1 Receptor Antagonist

Glucokinase Activator

CB1R Inverse Agonist -
Taranabant
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