Astrocytes: Wiring the Brain

Overview

An up to date look at the role of astrocytes in CNS function and dysfunction, this volume emphasizes the unique capacity of astrocytes for diverse cellular connection and the resulting implications. Beginning with an examination of functional biomarkers at the cellular interface between astrocytes and a wide range of CNS cells, chapters cover molecular components including ion channels, transporters, and membrane receptors; astrocyte types and subtypes; and astrocyte cellular partners such as neurons, ...

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Overview

An up to date look at the role of astrocytes in CNS function and dysfunction, this volume emphasizes the unique capacity of astrocytes for diverse cellular connection and the resulting implications. Beginning with an examination of functional biomarkers at the cellular interface between astrocytes and a wide range of CNS cells, chapters cover molecular components including ion channels, transporters, and membrane receptors; astrocyte types and subtypes; and astrocyte cellular partners such as neurons, oligodendrocytes, and brain endothelial cells. The second section considers the astrocyte action in epilepsy, neuro-inflammation, and psychiatric disorders.

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Product Details

  • ISBN-13: 9781439825846
  • Publisher: Taylor & Francis
  • Publication date: 12/1/2011
  • Series: Frontiers in Neuroscience Series
  • Pages: 440
  • Product dimensions: 6.00 (w) x 9.10 (h) x 1.20 (d)

Meet the Author

Eliana Scemes obtained her PhD from the University of Sao Paulo (USP), Brazil, and joined the faculty of the Institute of Biosciences at USP, where her research was primarily on nervous systems of jellyfish and the marine mollusk Aplysia. She spent two sabbatical years at Einstein and joined the faculty at Einstein College of Medicine in 1997, becoming Professor in 2010. Her current research interest is in the role of connexin and pannexin channels in astrocytes and brain pathophysiology.

David C. Spray obtained his PhD from the University of Florida College of Medicine and after a postdoctorate, joined the faculty at Einstein College of Medicine, where he became Professor of Neuroscience in 1986 and Medicine (Cardiology) in 1993. His major research interest is in gap junctions, primarily in physiological studies of their modulations and functions in the nervous system and elsewhere, and also in studies of regulation of gap junction and other genes in various pathological conditions, including parasitic infections causing Chagas disease and cerebral malaria.

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Table of Contents

Introduction to Cluster A: Functional Biomarkers at the Interface
Mature Protoplasmic Mammalian Astrocytes: Morphology, Interrelationships, and Implications for Function; H. K. Kimelberg
Biomarkers of Astrocyte Microdomains: Focus on Gap Junctions, Purinergic Receptors, and Aquaporins; E. Scemes and G. P. Nicchia
Adhesion Molecules and their Function in Astrocyte Polarity; S. Carbonetto, E. Camand, and S. Etienne-Manneville
Contribution of Astrocytes to CNS Immunity: Roles of Pattern Recognition Receptors (PRRs); N. Esen and T. Kielian
Introduction to Cluster B: Establishment of Functional Units: Multimodality at the Tips
Neuroglial Networks: Glial Wiring Also Matters; C. Giaume
Astrocyte-Neuron Communication: What Goes Wrong in Pathology? D. Rossi and A. Volterra
Blood-Brain Barrier and the Neural Vascular Unit; R. Dermietzel and D. C. Spray
Oligodendrocytes: Gateway to the Panglial Syncytium; K. G. V. Davidson and J. E. Rash
Microglia and Non-CNS Cells in Paracrine Signaling and CNS Immunity: Effects of Pathogens, Age, and Life History; E. H. Wilson and M. J. Carson
CNS Pathology: Disruption of Astrocyte Connectivity: Introduction
Astrocytes in Epilepsy; C. Steinhäuser and G. Seifert
Astrocyte Involvement in the Acquired Demyelinating Diseases; S. E. Lutz, C. S. Raine, and C. Brosnan
Neuroglia in Alzheimer’s Disease; J. J. Rodríguez Arellano, C. Matute and A. Verkhratsky
The Role of Glial Pathology in Autism; R. E. Kneeland, S. B. Liesch, T. D. Folsom, and S. H. Fatemi
Astrocytes in Major Depressive Disorder and Schizophrenia: Pathophysiological and Therapeutic Aspects; M. J. Schwarz and A.-M. Myint
Index

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