Astrocytes: Pharmacology and Function

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Editorial Reviews

Booknews
Interest in the functional roles of astrocytes in the nervous system has grown significantly as these cells are recognized not only as having their own pharmacology but also as releasing neuro- and vaso- active factors. This volume for neuroscientists relates astrocyte pharmacology to cell function. It discusses the pharmacological regulation of specific astrocyte functions, covers functional interactions between these and adjacent central nervous system cell types, examines regional heterogeneity of astrocytes with respect to receptor expression, and compares in vitro and in vivo approaches. Annotation c. Book News, Inc., Portland, OR (booknews.com)
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Product Details

  • ISBN-13: 9780125113700
  • Publisher: Elsevier Science & Technology Books
  • Publication date: 2/26/1993
  • Pages: 457

Table of Contents

Contributors
Preface
Ch. 1 Astrocyte Origins
II Types of Astrocytes in Vivo 1
III Molecular Markers for Astrocytes 3
IV Types of Astroglia in Vitro 4
V Characteristics of Glial Precursor Cells and Developmental Pathways in Vivo 8
VI Regional Differences in Astroglial Origins 11
VII Matching Astrocyte Types in Vivo and in Vitro 12
Pt. 1 Astrocytes as Target Cells
Ch. 2 Astroglial Adrenergic Receptors
II Astroglial Adrenergic Receptors 26
III Type 2-like Astroglia Exhibit Neuroligand Receptors 38
IV Astrocytes in Vivo Exhibit Neuroligand Receptors 39
V Astroglial Properties Influenced by Adrenergic Receptors 40
Ch. 3 Amino Acid Receptors
II Astrocyte GABA and GLU Receptors 48
III Functional Correlates of Astrocyte GABA and GLU Receptor Stimulation 55
Ch. 4 Biochemical Responses of Astrocytes to Neuroactive Peptides
II Second Messenger Systems 68
III Peptide Receptors on Astrocytes in Vitro 69
IV Peptide Receptors on Astrocytes in Vivo 80
Ch. 5 Astrocytes: Targets and Sources for Purines, Eicosanoids, and Nitrosyl Compounds
II Purines and Their Effects 90
III Arachidonic Acid and Eicosanoids 98
IV Nitrosyl Compounds 99
V Functional Significance of Astrocyte Eicosanoid and Nitrosyl Products 102
Ch. 6 Early Response Gene Expression Signifying Functional Coupling of Neuroligand Receptor System in Astrocytes
II Early Response Genes 110
III Neuroligand Induction of Early Response Genes 115
Ch. 7 Voltage-Dependent Ionic Channels in Astrocytes
II Potassium Channels 138
III Chloride Channels 150
IV Calcium Channels 151
V Sodium Channels 158
Pt. 2 Astrocyte Influences on Neurons
Ch. 8 Astrocyte Amino Acids: Evidence for Release and Possible Interactions with Neurons
Ch. 9 Regulation of the Brain Microenvironment: Transmitters and Ions
II Transmitter Uptake 194
III Ion Uptake 203
III Mechanisms of Network Communication 312
IV Functional Relationships of Astrocyte Networks to Neuronal Signaling 320
Ch. 14 Astrocyte-Oligodendrocyte Interactions
II A Novel Gap Junction in Question 332
III Astroglial Regulation of Myelinogenesis in Culture 335
IV Astrocytes as Mediators of Demyelination 344
Ch. 15 Astrocyte-Microglia Interactions
II Glial Cells 356
III Immune Cell-Derived Cytokines 357
IV Cytokines in the Central Nervous System 362
Ch. 16 Astrocyte-Endothelial Cell Interactions
II In Vivo Studies of Interactions between Astrocytes and Endothelium 385
III In Vitro Studies of Interactions between Astrocytes and Endothelium 386
IV Correlation of in Vivo and in Vitro Studies of the Interactions of Astrocytes and Endothelial Cells 394
Ch. 17 Human Astrocytic Neoplasms
I Definition and Grades of Gliomas 399
II Biologically Active Factors and Their Receptors 406
III Expression of Glial and Mesenchymal Features 414
Index 437
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