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Doody's Review ServiceReviewer: John F. Moran, MD (Loyola University Stritch School of Medicine)
Description: This book on hypertension, one in the series of the Atlas of Heart Disease, starts with a discussion of the pathogenesis of hypertension that points out that it is probably the result of societal as well as genetic interaction such as salt intake, obesity, caloric excess and social issues such as alcoholism. The book ends with a chapter on blood pressure measurements.
Purpose: The purpose is to provide information on hypertension in an easily digestible fashion through many illustrations, graphs, and tables. There is much information here dealing with hypertension from sodium intake to pharmacogenetics. A discussion of our Paleolithic genes and environmental influences is included.
Audience: This beautifully illustrated book would be appropriate for internal medicine specialists, medical residents, and even medical students. There is much material here that could be of benefit to all physicians since hypertension is so common.
Features: This atlas, consisting of 15 chapters written by 22 authors, is a collection of micrographs, angiograms, drawings, graphs, and tables with detailed legends covering all aspects of hypertension. There are many graphs of data all clearly presented; for example, lists of blood pressure trials with odd ratios in treated and untreated hypertensive patients. The trials go back to some of the early Veterans Administration trials to more current trials such as ALLHAT. Nicely presented material on molecular cloning of genes for renin, angiotensin, angiotensin converting enzymes and angiotensin receptors is provided. The information is detailed and presents known data on apoptosis effect of the angiotensin receptor. Vascular remodeling and hypertension is covered as well as the concept of mono therapy for hypertension and the action of antihypertensive medications. Since many antihypertensive medications have side effects, an evaluation of the quality of life in patients taking various medications is presented. Although the new agent Ompatrilat is reviewed, hypertensive guidelines from JNCV are also presented. However, JNCVI guidelines are now available.
Assessment: This third edition of the atlas is, as in previous editions, beautifully illustrated. The advantage the atlas has compared to other books in the field is that it illustrates its points through graphs, tables, and micrographs, etc. The legends are good and allow the information to be easily understood.