Autoimmune Disease: Aetiopathogenesis, Diagnosis and Treatment

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The outstanding advances in our understanding of the immune system of the last 20 years have thrown up the important concept of the body's ability, and occasional inability, to launch an immune response against components of its very self. Therefore, it was thought appropriate to bring together some of the world's most eminent contributors to this increasingly important specialism so as to pool their knowledge and arrive at a reflection of the diversity of current research and understanding in this area. This ...
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Overview

The outstanding advances in our understanding of the immune system of the last 20 years have thrown up the important concept of the body's ability, and occasional inability, to launch an immune response against components of its very self. Therefore, it was thought appropriate to bring together some of the world's most eminent contributors to this increasingly important specialism so as to pool their knowledge and arrive at a reflection of the diversity of current research and understanding in this area. This volume is the result of an international meeting convened in honour of the contributions of Professor Ivan Roitt, much of whose research over the last 40 years has made seminal contributions towards our understanding in this rich area of immunological research

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Product Details

  • ISBN-13: 9780632037995
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 12/12/1994
  • Edition number: 1
  • Pages: 272

Table of Contents

Contributors
Preface
Ivan Roitt FRS
1 Focus on Autoimmune Diseases: Analysis of B Cells in Rheumatoid Inflammation by Hybridoma Clones 3
2 Mechanisms Involved in Breakdown of Tolerance to Self 17
3 The Human B Cell Repertoire: Is Repertoire Bias a Manifestation of Life Saver V[subscript H] Genes? 32
4 The Nature of the Antigens Driving Autoimmune Disease 54
5 On the Origin of Human Autoantibodies 69
6 The Regulation of Autoimmunity through CD4 + ve T Cells 79
7 Thyroglobulin: A Model Autoantigen 92
8 Cellular and Genetic Mechanisms at the Origin of Systemic Lupus Erythematosus: A Unifying Hypothesis 105
9 Cytokine Profiles in Human Diseases with Particular Attention to Rheumatoid Arthritis 119
10 Diagnosis of Autoimmune Disease: Past and Present 137
11 Antigen Receptors as Targets for Therapy in Autoimmune Diseases 157
12 Reprogramming the Immune System 164
13 Cyclosporin and Some New Immunosuppressive Drugs in the Treatment of Autoimmune Diseases 169
14 The Potential for Antisense and Antigene Treatment of Human Disease 219
Index 247
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