The Bacteria: Their Origin, Structure, Function and Antibiosis / Edition 1

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Overview

The book's purpose is to give an explanation of the development of life on earth to the evolution of diversity. It is this diversity that led, almost automatically, to the development of pathogens and predators. The relationship of pathogens and host lead to the development of antibiotics and resistance mechanisms. Man has extended this process and we now have a situation in which new antibiotics are only effective for a short time. If we are to create long term antibiotics we must design them with this history in mind.

Understanding antibiotic chemotherapy at the ecological level is necessary for more permanent advances in development and in the usage of antibiotic agents in the past, present, and in the future. This book is intended for students at various levels who will be the microbiology researchers in the time to come. Also microbiology professors, particularly those teaching medical microbiology as well as physicians administrating antibiotics daily and researchers in the pharmaceutical industry may find this book useful.

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Product Details

  • ISBN-13: 9781402032059
  • Publisher: Springer Netherlands
  • Publication date: 6/15/2006
  • Edition description: 2006
  • Edition number: 1
  • Pages: 224
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.63 (d)

Table of Contents

1 The origin of life based on physical principles 3
2 Preamble to life 9
3 The first cell 15
4 Development of cell physiology and diversity 21
5 Covalent bonds and tensile strength of materials 39
6 Structure of the fabric that covers a bacterium 49
7 The covalently linked sacculus : the nona-muropeptide model 61
8 The structure of the tessera; the unit structure of murein wall 71
9 Extrusion and incorporation into the wall 77
10 The role of poles in the growth strategy of bacteria 81
11 Sidewalls of gram-negative rod-shaped bacteria 91
12 Growth strategies for gram-positive cells 99
13 Wall growth strategies for gram-negative cells 109
14 Commas, vibrios, spirilla, and helicobacters; tapered and branched bacteria 119
15 Spirochetes and spiroplasma and the special strategies for CWD (cell wall deficient) cells 137
16 Coccal versus rod-shaped cells, and the first bacterium 147
17 Diseases : old and new 161
18 Lysozymes as alternatives to [beta]-lactams antibiotics acting on the bacterial wall 181
19 Development of wall antibiotics and bacterial counter-measures 185
20 Antibiotics and resistance, with an emphasis on aminoglycosides 201
21 Future chemotherapy aimed at the bacterial murein 209
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