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Bacterial Pathogenesis: A Molecular Approach / Edition 1

Bacterial Pathogenesis: A Molecular Approach / Edition 1

by Abigail A. Salyers, Dixie D. Whitt

ISBN-10: 1555810705

ISBN-13: 9781555810702

Pub. Date: 06/28/1994

Publisher: ASM Press

Bacterial Pathogenesis: A Molecular Approach is the first text designed to provide a comprehensive introduction to this dynamic field for both students and researchers. The application of molecular techniques to the study of bacterium-host interaction has made possible great progress in fundamental understanding of the molecular basis of infectious diseases. In the


Bacterial Pathogenesis: A Molecular Approach is the first text designed to provide a comprehensive introduction to this dynamic field for both students and researchers. The application of molecular techniques to the study of bacterium-host interaction has made possible great progress in fundamental understanding of the molecular basis of infectious diseases. In the text the authors integrate material from pathogenic microbiology, molecular biology, immunology, and human physiology to provide a complete but accessible overview of the field.

Product Details

ASM Press
Publication date:
Edition description:
Older Edition
Product dimensions:
8.54(w) x 10.93(h) x 0.85(d)

Table of Contents

Part IBasic Principles1
Chapter 1The Uneasy Truce: Never Underestimate the Power of Bacteria3
Why Bacteria Are Once Again in the Public Health Spotlight3
Ancient History Takes a Toll on Today's Human Health4
Pressing Current Issues5
New Solutions, New Hope14
And Now for the Really Good News--You've Got a Bacterial Infection15
Chapter 2Approaching and Studying Bacterial Diseases19
Microbes and Disease19
Measuring Infectivity and Virulence24
Chapter 3Molecular Approaches to the Diagnosis and Characterization of Bacterial Infections34
Seeking Insights into Virulence34
Molecular Microbe Hunting36
Identifying Virulence Factors Experimentally42
Chapter 4The First Line of Defense against Infection: Prevention and the Phagocytic Cell Response53
An Ounce of Prevention53
Nonspecific and Specific Defenses54
Defenses of Skin57
Defenses of Mucosal Surfaces60
Phagocytes and Nonspecific Cytotoxic Cells: Defenders of Blood and Tissue60
Chapter 5The First Line of Defense, Continued: Complement, Chemokines, and Cytokines69
Characteristics and Roles of Complement69
Steps in Complement Activation71
Role of Cytokines and Chemokines in Directing the Phagocyte Response72
Other Activities of Cytokines76
Stress and Resistance to Disease: Connections between the Nervous System and the Immune System77
The Dark Side of the Nonspecific Defenses: Septic Shock77
Chapter 6The Second Line of Defense: Antibodies and Cytotoxic T Cells84
Cytotoxic T Cells88
Production of Activated Cytotoxic T Cells and Antibodies88
Mucosal Immunity93
Development of the Specific Response System from Infancy to Adulthood95
The Dark Side of the Specific Defenses--Autoimmune Disease95
Chapter 7Vaccination--an Underappreciated Component of the Modern Medical Armamentarium101
Vaccines--a Major Health Care Bargain101
A New Form of Child Abuse (as if We Needed One)103
The Success Stories105
The Less-than-Success Stories108
New Directions111
Passive Immunization112
Chapter 8Bacterial Strategies for Evading or Surviving the Defense Systems of the Human Body115
Overview of Bacterial Defense Strategies115
Colonization and Invasion of Host Surfaces116
Evading Complement, Phagocytes, and the Antibody Response123
Chapter 9Bacterial Exotoxins: Important but Still a Mystery131
Exotoxins, Toxic Proteins Produced by Bacteria131
Examples of Diseases Caused by Toxins138
Chapter 10Antimicrobial Compounds150
Antimicrobial Compounds: the Safety Net of Modern Medicine150
Antiseptics and Disinfectants151
Mechanisms of Antibiotic Action156
The Continuing Challenge163
Chapter 11How Bacteria Become Resistant to Antibiotics168
The Dawning of Awareness168
Mechanisms of Antibiotic Resistance170
Antibiotic Tolerance177
Transfer of Resistance Genes177
Will We Return to the Preantibiotic Era?180
Part IISpecific Bacterial Pathogens185
Chapter 12The Spirochetes: Borrelia burgdorferi and Treponema pallidum187
Lyme Disease188
Features of B. burgdorferi188
The Borrelia Genome Sequence--Some Clues but Still Many Mysteries190
The Tick-Mammal Cycle192
Response of B. burgdorferi to Its Arthropod and Mammalian Hosts192
Studying Virulence Factors of B. burgdorferi195
Diagnosis and Prevention of Lyme Disease195
Syphilis and Lyme Disease: Two Spirochetal Diseases with a Similar Pathology but a Different Ecology197
Taking Stock198
Chapter 13Yersinia pestis, the Cause of Plague, and Its Relatives202
The Rich and Terrible History of Yersinia pestis202
Virulence Factors of Y. pestis, Y. enterocolitica, and Y. pseudotuberculosis208
Future Directions213
Chapter 14Staphylococcus Species216
The Many Types of Staphylococcal Infections216
Characteristics of Staphylococci219
Virulence Factors of S. aureus220
Virulence Factors of the Coagulase-Negative Staphylococci227
Future Directions228
Chapter 15Group A and Group B Streptococci and Enterococci232
A Closer Look at Diseases Caused by Streptococci233
Group B Streptococci and Enterococci--Emerging Human Pathogens236
Virulence Factors237
Chapter 16Pseudomonas aeruginosa and Related Species, a Lesson in Versatility247
A Consummate Opportunist247
Characteristics of P. aeruginosa248
Types of Infections249
Virulence Factors251
Future Directions260
Chapter 17Bordetella pertussis263
Whooping Cough263
Virulence Factors264
Regulation of Virulence Genes270
Prevention and Treatment272
Chapter 18Streptococcus pneumoniae276
Pneumococcal Disease276
Virulence Factors of S. pneumoniae279
Prevention and Treatment285
Chapter 19Tuberculosis291
A Disease of the Past Returns To Haunt the Future291
Spread and Progression of Tuberculosis293
Mycobacterium tuberculosis and Its Unusual Cell Wall--a Case of Fat Making for Lean and Mean298
Treatment of TB and the Challenge Posed by Drug-Resistant Strains298
Diagnosis of TB302
Virulence Factors303
Immunity to TB306
Chapter 20Legionella pneumophila and Legionnaires' Disease311
The Dark Side of Modern Comforts: Air-Conditioning Turns Ugly311
Legionnaires' Disease312
The Natural Host?--a Free-Living Macrophage Equivalent312
Virulence Factors313
Prevention and Treatment318
Legionella as a Paradigm for Intracellular Pathogens318
Chapter 21Mycoplasma pneumoniae and Chlamydia pneumoniae322
Lifestyles of Mycoplasma pneumoniae and Chlamydia pneumoniae322
Characteristics of Mycoplasma and Chlamydia Species325
Virulence Factors327
Chapter 22Bacillus anthracis, the Cause of Anthrax332
Features of the Disease332
Virulence Factors333
Prevention of Anthrax335
Chapter 23Helicobacter pylori, a Resourceful Gastric Pathogen339
A Revolution in Gastroenterology339
Characteristics of H. pylori342
Virulence Factors343
Prevention and Treatment346
H. pylori Mysteries349
Chapter 24Clostridium difficile and Pseudomembranous Colitis352
Pseudomembranous Colitis--a Disease Caused by Antibiotics352
Characteristics of C. difficile353
Development and Ecology of the Disease353
Virulence Factors355
Prevention and Treatment359
Chapter 25Vibrio cholerae, the Cause of Cholera363
Pathogenesis and Epidemiology of Cholera363
Virulence Factors366
Transcriptional Regulation of Virulence Genes375
Prevention and Treatment376
Future Directions377
Chapter 26Salmonella Species381
Salmonella Species and Serogroups381
Diseases Caused by Salmonella Species382
Virulence Factors384
Prevention and Treatment392
Future Directions394
Chapter 27Listeria monocytogenes, a Doubly Motile Pathogen398
Virulence Factors400
Organization and Regulation of Virulence Genes404
Prevention and Treatment404
Chapter 28Diarrheagenic Escherichia coli Strains407
Different Types of Diarrheagenic Escherichia coli Strains407
Classification of Pathogenic E. coli Strains408
Virulence Factors411
Prevention and Treatment416
Chapter 29Escherichia coli Extraintestinal Infections422
Epidemiology of Urinary Tract Infections422
Virulence Factors of E. coli Strains That Cause Urinary Tract Infections424
Meningitis and Other Disseminated Infections432
Prevention and Treatment433
Chapter 30Neisseria Species437
The Two Pathogenic Neisseria Species437
Meningococcal Meningitis440
Virulence Factors441
Prevention and Treatment447
Chapter 31Chlamydia trachomatis452
The Hidden Epidemic452
C. trachomatis--a Lot of Pathogenic Potential in a Very Small Package454
Virulence Factors456
Prevention and Treatment458
Closing Observations459
Appendix 1Overview of Bacterial Secretion Systems, Bacterial Adhesins and Their Mechanisms of Assembly, and Major Bacterial Toxins461
A.Secretion Systems of Bacteria461
B.Adhesins and Mechanisms of Assembly462
C.Major Bacterial Toxins464
Appendix 2Answers to End-of-Chapter Questions467

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