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Doody's Review ServiceReviewer: Randall Scott Lambrecht, PhD, MS (University of Wisconsin-Milwaukee)
Description: This book encompasses a broad range of concepts relating to the evolution, acquisition, development, and detection of antimicrobial resistance. There is a unique focus on the nature of antimicrobial resistance from multiple perspectives that emphasize the influence of the environment on the ecology of genes and phenotypic characteristics.
Purpose: The purpose of the book is described by the authors as a means to offer strategies to minimize the emergence and spread of antimicrobial resistance and to aid in the discovery of new agents effective against refractory strains. The book is a welcome addition to the existing body of knowledge and literature on antimicrobial resistance. The objectives are to address extremely complex and difficult issues in nature. The book provides a solid foundation for understanding the development and basis for antimicrobial resistance.
Audience: According to the authors, this book is intended for individuals actively working in the field. It is a useful and instructive text for graduate students and researchers in bacteriology, microbiology, public health, and related fields. The authors are well respected and reputable scientific professionals from a variety of venues: industry, academic, health sciences, governmental and public health sectors.
Features: The book is a comprehensive view of antimicrobial resistance from multiple perspectives. A variety of topics ranging from the influence of the environment, to genetic mechanisms, and phenotypic characteristics are addressed. The book is especially excellent at summarizing what is known about the global response systems and genetic mechanisms of resistance. This is an invaluable resource containing historical and current references and published research articles related to antimicrobial resistance. The organization of the topics and chapters in the book is somewhat confusing. For example, it is not clear why the discussion of "Resistance as a Worldwide Problem" does not occur until Chapter 10 — halfway through the book. The use of more illustrations would be helpful and there are a number of minor typos and grammatical errors throughout the book that should have been edited out.
Assessment: Overall, this informative book combines basic biological concepts with clinical and practical knowledge in dealing with antimicrobial resistance. It is an up-to-date reference that provokes and stimulates ideas and strategies for addressing the increasing problem of resistance. It provides critical analysis of the development of antimicrobial resistance from multiple scientific perspectives.