Bacterial Resistance to Antimicrobials


Focuses on combating bacterial pathogens by understanding their strategies of defense!

Each chapter begins with a summary of concepts, so those not actively working in the field gain an overall picture of what follows!

Highlights antibiotic resistance in pathogens that ...

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0824706358 USED BOOK in good condition| No supplements| Normal wear to cover, edges, spine, corners, and pages | Writing / highlighting | Inventory stickers | Satisfaction ... guaranteed! Read more Show Less

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Focuses on combating bacterial pathogens by understanding their strategies of defense!

Each chapter begins with a summary of concepts, so those not actively working in the field gain an overall picture of what follows!

Highlights antibiotic resistance in pathogens that poses the greatest threat to human health!

Containing nearly 2000 references for additional research, Bacterial Resistance to Antimicrobials

  • discusses the ecology of drug resistance genes, acquired response, and selection in natural bacterial populations
  • describes global response systems that are a basis of resistance
  • details antibiotic modification, inactivation, and host target modification as means of resistance development
  • considers efflux mechanisms, one of the major causes of multidrug resistance
  • covers concepts for developing therapies against multidrug resistant organisms
  • emphasizes the structural basis of lactamases and other enzymes involved in inactivation of antibiotics
  • surveys the epidemiology of methicillin resistance among nosocomial isolates and community-acquired strains
  • outlines molecular detection methods for mainstream diagnostic tests
  • assesses the promise of modern genomics to identify novel targets for drug discovery screening

Presenting the molecular basis, methods of detection and identification, and concepts for reducing the development and spread of resistant bacterial strains, Bacterial Resistance to Antimicrobials is an excellent reference for microbiologists, pharmacists, public health officials, infectious disease specialists, organic and medicinal chemists, and upper-level undergraduate and graduate students in these disciplines.

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Editorial Reviews

Doody's Review Service
Reviewer: Randall Scott Lambrecht, PhD, MS (University of Wisconsin-Milwaukee)
Description: This book encompasses a broad range of concepts relating to the evolution, acquisition, development, and detection of antimicrobial resistance. There is a unique focus on the nature of antimicrobial resistance from multiple perspectives that emphasize the influence of the environment on the ecology of genes and phenotypic characteristics.
Purpose: The purpose of the book is described by the authors as a means to offer strategies to minimize the emergence and spread of antimicrobial resistance and to aid in the discovery of new agents effective against refractory strains. The book is a welcome addition to the existing body of knowledge and literature on antimicrobial resistance. The objectives are to address extremely complex and difficult issues in nature. The book provides a solid foundation for understanding the development and basis for antimicrobial resistance.
Audience: According to the authors, this book is intended for individuals actively working in the field. It is a useful and instructive text for graduate students and researchers in bacteriology, microbiology, public health, and related fields. The authors are well respected and reputable scientific professionals from a variety of venues: industry, academic, health sciences, governmental and public health sectors.
Features: The book is a comprehensive view of antimicrobial resistance from multiple perspectives. A variety of topics ranging from the influence of the environment, to genetic mechanisms, and phenotypic characteristics are addressed. The book is especially excellent at summarizing what is known about the global response systems and genetic mechanisms of resistance. This is an invaluable resource containing historical and current references and published research articles related to antimicrobial resistance. The organization of the topics and chapters in the book is somewhat confusing. For example, it is not clear why the discussion of "Resistance as a Worldwide Problem" does not occur until Chapter 10 — halfway through the book. The use of more illustrations would be helpful and there are a number of minor typos and grammatical errors throughout the book that should have been edited out.
Assessment: Overall, this informative book combines basic biological concepts with clinical and practical knowledge in dealing with antimicrobial resistance. It is an up-to-date reference that provokes and stimulates ideas and strategies for addressing the increasing problem of resistance. It provides critical analysis of the development of antimicrobial resistance from multiple scientific perspectives.
Bulletin of the Royal College of Pathologies
...easy to read and manageable....a useful reference book....a comprehensive and straightforward guide.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780824706357
  • Publisher: CRC Press
  • Publication date: 1/28/2002
  • Pages: 528
  • Product dimensions: 6.20 (w) x 9.10 (h) x 1.60 (d)

Table of Contents

The Ecology of Antibiotic Resistance Genes Abigail A. Salyers, Nadja B. Shoemaker, and George T. Bonheyo

Antibiotic Resistance: How Bacterial Populations Respond to a Simple Evolutionary Force Fernando de la Cruz, Juan M. García-Lobo, and Julian Davies

Global Response Systems That Cause Resistance Paul F. Miller and Philip Rather

Drug Efflux Kim Lewis and Olga Lomovskaya

Mechanisms of Aminoglycoside Antibiotic Resistance Gerard D. Wright

b-Lactamases and Resistance to b-Lactam Antibiotics Lakshmi P. Kotra, Jean-Pierre Samama, and Shahriar Mobashery

Target Modification as a Mechanism of Antimicrobial Resistance David C. Hooper

Antibiotic Permeability Harry W. Taber

Phenotypic Tolerance of Bacteria Rodger Novak and Elaine I. Tuomanen

Resistance as a Worldwide Problem Rosamund Williams

Genetic Methods for Detecting Bacterial Resistance Genes Amalio Telenti and Fred C. Tenover

Evolution and Epidemiology of Antibiotic-Resistant Pneumococci Christopher Gerard Dowson and Krzysztof Trzcinski

Resistance Problems Associated with the Enterococcus George M. Eliopoulos

Methicillin Resistance in Staphylococcus aureus Keeta S. Gilmore, Daniel F. Sahm, and Michael S. Gilmore

Drug Resistance and Tuberculosis Chemotherapy-From Concept to Genomics Alexander S. Pym and Stewart T. Cole

Antibiotic Resistance in Enterobacteria Nafsika H. Georgopapadakou

Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings Richard E. Besser, Julia Y. Morita, and Scott K. Fridkin

Approaches to New Antimicrobial Targets in the Age of Genomics Philip J. Youngman


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