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Bacterial Resistance to Antimicrobials / Edition 2

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The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy.

Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem.

Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

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Editorial Reviews

Bulletin of the Royal College of Pathologies
...easy to read and manageable....a useful reference book....a comprehensive and straightforward guide.
From The Critics
Reviewer: Randall Scott Lambrecht, PhD, MS (University of Wisconsin-Milwaukee)
Description: This book encompasses a broad range of concepts relating to the evolution, acquisition, development, and detection of antimicrobial resistance. There is a unique focus on the nature of antimicrobial resistance from multiple perspectives that emphasize the influence of the environment on the ecology of genes and phenotypic characteristics.
Purpose: The purpose of the book is described by the authors as a means to offer strategies to minimize the emergence and spread of antimicrobial resistance and to aid in the discovery of new agents effective against refractory strains. The book is a welcome addition to the existing body of knowledge and literature on antimicrobial resistance. The objectives are to address extremely complex and difficult issues in nature. The book provides a solid foundation for understanding the development and basis for antimicrobial resistance.
Audience: According to the authors, this book is intended for individuals actively working in the field. It is a useful and instructive text for graduate students and researchers in bacteriology, microbiology, public health, and related fields. The authors are well respected and reputable scientific professionals from a variety of venues: industry, academic, health sciences, governmental and public health sectors.
Features: The book is a comprehensive view of antimicrobial resistance from multiple perspectives. A variety of topics ranging from the influence of the environment, to genetic mechanisms, and phenotypic characteristics are addressed. The book is especially excellent at summarizing what is known about the global response systems and genetic mechanisms of resistance. This is an invaluable resource containing historical and current references and published research articles related to antimicrobial resistance. The organization of the topics and chapters in the book is somewhat confusing. For example, it is not clear why the discussion of "Resistance as a Worldwide Problem" does not occur until Chapter 10:halfway through the book. The use of more illustrations would be helpful and there are a number of minor typos and grammatical errors throughout the book that should have been edited out.
Assessment: Overall, this informative book combines basic biological concepts with clinical and practical knowledge in dealing with antimicrobial resistance. It is an up-to-date reference that provokes and stimulates ideas and strategies for addressing the increasing problem of resistance. It provides critical analysis of the development of antimicrobial resistance from multiple scientific perspectives.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780849391903
  • Publisher: Taylor & Francis
  • Publication date: 11/21/2007
  • Edition description: REV
  • Edition number: 2
  • Pages: 448
  • Product dimensions: 6.20 (w) x 9.30 (h) x 1.20 (d)

Table of Contents

Microbial Drug Resistance: A Historical Perspective, W.C. Summers

Ecology of Antibiotic Resistance Genes, A.A. Salyers, N. Shoemaker, and D. Schlesinger

Global Response Systems that Confer Resistance, P.F. Miller and P.N. Rather

Multidrug Efflux Pumps: Structure, Efflux, and Inhibition, O. Lomovskaya, H.I. Zgurskaya, K.A. Bostian, and Kim Lewis

Mechanisms of Aminoglycoside Antibiotic Resistance, G.D. Wright

Resistance to ß-Lactam Antibiotics Mediated by ß-Lactamases, J.Y. Cha, L.P. Kotra, and S. Mobashery

Target Modification as a Mechanism of Antimicrobial Resistance, D.C. Hooper

Antibiotic Permeability, H. Taber

Genetic Methods for Detecting Bacterial Resistance Genes, A.C. Fluit

The Evolution and Epidemiology of Antibiotic Resistant Pneumococci, C.G. Dowson and K. Trzcinski

Antimicrobial Resistance in the Enterococcus, G.M. Eliopoulos

Methicillin Resistance in Staphylococcus aureus, K.S. Gilmore and M.S. Gilmore

Mechanism of Drug Resistance in Mycobacterium tuberculosis, A.S. Pym and S.T. Cole

Antibiotic Resistance in Enterobacteria, N.H Georgopapadakou

Resistance as a Worldwide Problem, P. Shears

Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings, C.R Friedman and A. Srinivasan

Antibacterial Drug Discovery in the 21st Century, S.J. Projan

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