Bacterial Resistance to Antimicrobials / Edition 2

Bacterial Resistance to Antimicrobials / Edition 2

by Richard G. Wax
     
 

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding

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Overview

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy.

Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem.

Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ß-lactam antibiotics with ß-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

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Product Details

ISBN-13:
9780849391903
Publisher:
Taylor & Francis
Publication date:
11/21/2007
Edition description:
REV
Pages:
448
Product dimensions:
6.20(w) x 9.30(h) x 1.20(d)

Table of Contents

Microbial Drug Resistance: A Historical Perspective, W.C. Summers

Ecology of Antibiotic Resistance Genes, A.A. Salyers, N. Shoemaker, and D. Schlesinger

Global Response Systems that Confer Resistance, P.F. Miller and P.N. Rather

Multidrug Efflux Pumps: Structure, Efflux, and Inhibition, O. Lomovskaya, H.I. Zgurskaya, K.A. Bostian, and Kim Lewis

Mechanisms of Aminoglycoside Antibiotic Resistance, G.D. Wright

Resistance to ß-Lactam Antibiotics Mediated by ß-Lactamases, J.Y. Cha, L.P. Kotra, and S. Mobashery

Target Modification as a Mechanism of Antimicrobial Resistance, D.C. Hooper

Antibiotic Permeability, H. Taber

Genetic Methods for Detecting Bacterial Resistance Genes, A.C. Fluit

The Evolution and Epidemiology of Antibiotic Resistant Pneumococci, C.G. Dowson and K. Trzcinski

Antimicrobial Resistance in the Enterococcus, G.M. Eliopoulos

Methicillin Resistance in Staphylococcus aureus, K.S. Gilmore and M.S. Gilmore

Mechanism of Drug Resistance in Mycobacterium tuberculosis, A.S. Pym and S.T. Cole

Antibiotic Resistance in Enterobacteria, N.H Georgopapadakou

Resistance as a Worldwide Problem, P. Shears

Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings, C.R Friedman and A. Srinivasan

Antibacterial Drug Discovery in the 21st Century, S.J. Projan

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