Basic Concepts in Molecular Medicine / Edition 1

Hardcover (Print)

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Volume 1 begins with an introduction covering the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics (how we harness diagnostic clues to guide treatment). The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.

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Table of Contents

Chapter 1

Molecular Medicine: The Future is Now

Geoffrey S. Ginsburg, M.D., Ph.D.

Center for Genome Science, Duke University School of Medicine, Durham, NC

Chapter 2

Genomic Classification of Disease

David P. Carbone, M.D., Ph.D.

Division of Hematology/Oncology, Department of Medicine, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN

Chapter 3

Transcriptomic Classification of Disease

Matt van de Rijn, M.D., Ph.D.

Department of Pathology, Stanford University School of Medicine, Stanford, CA

Chapter 4

Epigenomic Classification of Disease

Peter A. Jones, Ph.D.

Departments of Urology, Biochemistry, and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA

Chapter 5

Proteomic Classification of Disease

Lance Liotta, Ph.D.

The Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA

Chapter 6

Molecular Medicine in Neoplastic Disease

Gavin J. Gordon, Ph.D.

Department of Surgery Research, Dana Farber/Harvard Medical Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA

Chapter 7

Molecular Medicine in Genetic Disease

Markus Grompe, M.D.

Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR

Chapter 8

Molecular Medicine in Infectious Disease

Michael G. Bergeron, Ph.D.

Research Center in Infectious Diseases, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada

Chapter 9

Molecular Diagnostics: Harnessing the Clues to Direct the Treatment of Human Disease

William B. Coleman, Ph.D., and Gregory J. Tsongalis, Ph.D.

Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, and Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH

Chapter 10

Personalized Treatment of Complex Diseases: The Promise of Molecular Medicine

Leroy E. Hood, M.D., Ph.D.

Institute for Systems Biology, Department of Molecular and Cellular Biology, University of Washington, Seattle, WA

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