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Volume 1 begins with an introduction covering the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics (how we harness diagnostic clues to guide treatment). The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.
Molecular Medicine: The Future is Now
Geoffrey S. Ginsburg, M.D., Ph.D.
Center for Genome Science, Duke University School of Medicine, Durham, NC
Genomic Classification of Disease
David P. Carbone, M.D., Ph.D.
Division of Hematology/Oncology, Department of Medicine, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN
Transcriptomic Classification of Disease
Matt van de Rijn, M.D., Ph.D.
Department of Pathology, Stanford University School of Medicine, Stanford, CA
Epigenomic Classification of Disease
Peter A. Jones, Ph.D.
Departments of Urology, Biochemistry, and Molecular Biology, University of Southern California/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA
Proteomic Classification of Disease
Lance Liotta, Ph.D.
The Center for Applied Proteomics and Molecular Medicine, George Mason University, Manassas, VA
Molecular Medicine in Neoplastic Disease
Gavin J. Gordon, Ph.D.
Department of Surgery Research, Dana Farber/Harvard Medical Center, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA
Molecular Medicine in Genetic Disease
Markus Grompe, M.D.
Department of Molecular and Medical Genetics, Oregon Health and Science University, Portland, OR
Molecular Medicine in Infectious Disease
Michael G. Bergeron, Ph.D.
Research Center in Infectious Diseases, Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
Molecular Diagnostics: Harnessing the Clues to Direct the Treatment of Human Disease
William B. Coleman, Ph.D., and Gregory J. Tsongalis, Ph.D.
Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, and Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH
Personalized Treatment of Complex Diseases: The Promise of Molecular Medicine
Leroy E. Hood, M.D., Ph.D.
Institute for Systems Biology, Department of Molecular and Cellular Biology, University of Washington, Seattle, WA