BN.com Gift Guide

Basic Pharmacokinetics and Pharmacodynamics: An Integrated Textbook and Computer Simulations / Edition 1

Paperback (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $48.15
Usually ships in 1-2 business days
(Save 19%)
Other sellers (Paperback)
  • All (8) from $48.15   
  • New (7) from $48.15   
  • Used (1) from $49.59   

Overview

With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study.

By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts:

  • Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles
  • Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems
  • Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses

Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Gregory Reed, PhD (University of Kansas Medical Center)
Description: This is primarily an introductory book on kinetics and actions of drugs for pharmacy and medical students. It also may serve as a refresher and self-study guide for other basic science and clinical practitioners needing an appreciation of these topics.
Purpose: The author's goal is to provide a conceptual and mathematical framework for understanding pharmacokinetics and pharmacodynamics. She makes the case that this can only be accomplished by "understanding, not memorizing" the material. This is indeed the case, and the presentation and development of concepts in this book should enable students to develop that understanding of these fundamental concepts and their applications.
Audience: This should be a very successful book for pharmacy and medical students beginning their study of pharmacokinetics and pharmacodynamics. I would expand that audience to include graduate and postdoctoral students in basic biomedical sciences. It also can be used as a reasonable study guide for occasional practitioners in need of a self-directed refresher.
Features: Concepts are initially introduced in quite simplified terms, and then developed through the addition of relevant features. Where appropriate, this development includes quantitative mathematical treatments and graphical representations. The inclusion of math and graphical presentations supports the development of understanding, as opposed to mere memorization. It is notable that the mathematical derivations and developments are truly step by step - unlike some treatments of this type that combine multiple steps in the transition from one equation to another, greatly complicating the process for novices. This same, thorough approach is used to work through examples in the book. The tables and figures effectively support the text. Most chapters also include a number of sample problems to allow readers to apply the principles. The book includes access to online computer simulations to illustrate many of these points. There are several appendixes, including one presenting a review of exponents and logarithms, and another a review of rate equations. Although I would like to say these topics are prerequisites with which students should already be familiar, this is not the case. Including these resources will be very helpful to many students. I have but two criticisms. Occasionally, the presentation of topics is oversimplified — case in point would be the figure and discussion for oral absorption, which includes hepatic clearance from metabolism, but not from biliary secretion of parent drug. Also, the computer simulations do not add much beyond what is quite clearly presented in the text.
Assessment: In short, this is a thorough and well-designed presentation and development of key concepts in pharmacokinetics and pharmacodynamics. It is a very useful textbook, and one that I would be comfortable using in both medical and graduate teaching.
From the Publisher
“I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD that may fill a small niche in a well-served market. “ (British Toxicology Society Newsletter, 1 June 2012)

"In summary, I believe that this book is successful in what it sets out to do. For those readers who are interested in getting to grips with the basics of the time course of onset, offset and extent of drug effects then this is the book for you. I am certainly recommending this book for my graduate students." (British Journal of Clinical Pharmacology, 2011)

"A readable font size, good quality paper and a stout binding make this an excellent offering ... This is an ideal textbook for those starting out on the pharmacokinetic trail and also for use as a reference book for those who delve occasionally into this subject." (International Society for the Study of Xenobiotics, 1 April 2012)

"In short, this is a thorough and well-designed presentation and development of key concepts in pharmacokinetics and pharmacodynamics. It is a very useful textbook, and one that I would be comfortable using in both medical and graduate teaching." (Doody's, 21 October 2011)

Read More Show Less

Product Details

  • ISBN-13: 9780470569061
  • Publisher: Wiley
  • Publication date: 5/24/2011
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 448
  • Sales rank: 714,312
  • Product dimensions: 7.00 (w) x 9.90 (h) x 0.80 (d)

Meet the Author

Sara E. Rosenbaum, PhD, is Professor of Biomedical and Pharmaceutical Sciences at the University of Rhode Island, where she teaches courses in pharmacokinetics. She is also the former editor-in-chief of Clinical Research and Regulatory Affairs. Dr. Rosenbaum's research interests concentrate on the development and application of pharmacokinetic and pharmacodynamic models that build our understanding of the drug dose-response relationship.

Read More Show Less

Read an Excerpt

catalogimages.wiley.com/images/db/pdf/9780470569061.excerpt.pdf
Read More Show Less

Table of Contents

Preface.

1. Introduction to Pharmacokinetics and Pharmacodynamics.

1.1 Introduction: Drugs and Doses.

1.2 Introduction to Pharmacodynamics.

1.3 Introduction to Pharmacokinetics.

1.4 Dose-Response Relationships.

1.5 Therapeutic Range.

1.6 Summary.

2. Passage of Drugs Through Membranes.

2.1 Introduction.

2.2 Structure and Properties of Membranes.

2.3 Passive Diffusion.

2.4 Carrier-Mediated Processes: Transport Proteins.

3. Drug Administration, Absorption, and Bioavailability.

3.1 Introduction: Local and Systemic Drug Administration.

3.2 Common Routes of Systemic Drug Administration.

3.3 Overview of Oral Absorption.

3.4 Extent of Drug Absorption.

3.5 Determinants of the Bioavailability.

3.6 Factors Controlling the Rate of Drug Absorption.

3.7 Biopharmaceutics Classification System.

Problems.

References. 

4. Drug Distribution.

4.1 Introduction.

4.2 Extent of Drug Distribution.

4.3 Rate of Drug Distribution.

4.4 Distribution of Drugs to the Central Nervous System.

Problems.

References.

5. Drug Elimination and Clearance.

5.1 Introduction.

5.2 Clearance.

5.3 Renal Clearance.

5.4 Hepatic Clearance.

5.5 Measurement of Clearances.

Problems.

References. 

6. Compartmental Models in Pharmacokinetics.

6.1 Introduction.

6.2 Expressions for Component Parts of the Dose-Plasma.

6.3 Putting Everything Together: Compartments and Models.

6.4 Examples of Complete Compartment Models.

6.5 Use of Compartmental Models to Study Metabolite Pharmacokinetics.

6.6 Selecting and Applying Models.

Problems.

Recommended Reading. 

7. Pharmacokinetics of an Intravenous Bolus Injection in a One-Compartment Model.

7.1 Introduction.

7.2 One-Compartment Model.

7.3 Pharmacokinetic Equations.

7.4 Simulation Exercise.

7.5 Application of the Model.

7.6 Determination of Pharmacokinetic Parameters Experimentally.

7.7 Pharmacokinetic Analysis in Clinical Practice.

Problems.

Recommended Reading. 

8. Pharmacokinetics of an Intravenous Bolus Injection in a Two-Compartment Model.

8.1 Introduction.

8.2 Tissue and Compartment Distribution of a Drug.

8.3 Basic Equation.

8.4 Relationship Between Macro and Micro Rate Constants.

8.5 Primary Pharmacokinetic Parameters.

8.6 Simulation Exercise.

8.7 Determination of the Pharmacokinetic Parameters of the Two-Compartment Model.

8.8 Clinical Application of the Two-Compartment Model.

Problems.

Recommended Reading. 

9. Pharmacokinetics of Extravascular Drug Administration.

9.1 Introduction.

9.2 Model for First-Order Absorption in a One-Compartment Model.

9.3 Bioavailability.

9.4 Simulation Exercise.

Problems.

Recommended Reading. 

10. Introduction to Noncompartmental Analysis.

10.1 Introduction.

10.2 Mean Residence Time.

10.3 Determination of Other Important Pharmacokinetic Parameters.

10.4 Different Routes of Administration.

10.5 Application of Noncompartmental Analysis to Clinical Studies.

Problems. 

11. Pharmacokinetics of Intravenous Infusion in a One-Compartment Model.

11.1 Introduction.

11.2 Model and Equations.

11.3 Steady-State Plasma Concentration.

11.4 Loading Dose.

11.5 Termination of Infusion.

11.6 Individualization of Dosing Regimens.

Problems. 

12. Multiple Intravenous Bolus Injections in the One-Compartment Model.

12.1 Introduction.

12.2 Terms and Symbols Used in Multiple-Dosing Equations.

12.3 Monoexponential Decay During a Dosing Interval.

12.4 Basic Pharmacokinetic Equations for Multiple Doses.

12.5 Steady State.

12.6 Basic Formula Revisited.

12.7 Pharmacokinetic-Guided Dosing Regimen Design.

12.8 Simulation Exercise.

Problems.

References. 

13. Multiple Intermittent Infusions.

13.1 Introduction.

13.2 Steady-State Equations for Multiple Intermittent.

13.3 Monoexponential Decay During a Dosing Interval: Dtermination of Peaks, Troughs, and Elimination Half-Life.

13.4 Determination of the Volume of Distribution.

13.5 Individualization of Dosing Regimens.

13.6 Simulation Exercise.

Problems. 

14. Multiple Oral Doses.

14.1 Introduction.

14.2 Steady-State Equations.

14.3 Equations Used Clinically to Individualize Oral Doses.

14.4 Simulation Exercise.

Problems. 

15. Nonlinear Pharmacokinetics.

15.1 Linear Pharmacokinetics.

15.2 Nonlinear Processes in Absorption, Distribution, Metabolism, and Elimination.

15.3 Pharmacokinetics of Capacity-Limited Metabolism.

15.4 Phenytoin.

Problems.

References. 

16. Introduction to Pharmacodynamic Models and Integrated Pharmacokinetic-Pharmacodynamic Models.

16.1 Introduction.

16.2 Classic Pharmacodynamic Models Based on Traditional Receptor Theory.

16.3 Empirical Pharmacodynamic Models Used Clinically.

16.4 Integrated PK-PD Models: Emax Models Combined with a PK Model for Intravenous Bolus Infection in a One-Compartment Model.

16.5 Hystersis and the Effect Compartment.

Problems.

References. 

17. Mechanism-Based Integrated Pharmacokinetic-Pharmacodynamic Models.

17.1 Introduction.

17.2 Alternative Models for Drug-Receptor Interaction: Operational Model of Agonism.

17.3 Physiological Turnover Model and Its Characteristics.

17.4 Indirect Effect Models.

17.5 Transduction and Transit Compartment Models.

17.6 Tolerance Models.

17.7 Irreversible Drug Effects.

17.8 Disease Progression Models.

Problems.

References. 

Appendix A. Review of Exponents and Logarithms.

Appendix B. Rates of Processes.

Appendix C. Creation of Excel Worksheets for Pharmacokinetic Analysis.

Appendix D. Derivation of Equations for Multiple Intravenous Bolus Injections.

Appendix E. Summary of the Properties of the Fictitious Drugs Used in the Text.

Appendix F. Computer Simulation Models.

Glossary of Abbreviations and Symbols.

Index.  

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)