Basic Virology / Edition 33

Paperback (Print)
Rent
Rent from BN.com
$33.80
(Save 75%)
Est. Return Date: 07/05/2015
Buy New
Buy New from BN.com
$118.87
Buy Used
Buy Used from BN.com
$87.55
(Save 35%)
Item is in good condition but packaging may have signs of shelf wear/aging or torn packaging.
Condition: Used – Good details
Used and New from Other Sellers
Used and New from Other Sellers
from $11.01
Usually ships in 1-2 business days
(Save 91%)
Other sellers (Paperback)
  • All (19) from $11.01   
  • New (9) from $53.70   
  • Used (10) from $11.01   

Overview

Ideal for the student seeking a solid understanding of the basic principles in this rapidly developing field, this best-selling text offers a comprehensive introduction to the fundamentals of virology. Featuring an enhanced art program now in full-color, the new edition has been updated throughout.
• New edition incorporates additional reading suggestions, expanded review questions, chapter outlines and full-colour artwork
• Contains new chapters dealing with viruses and cancer, generation and use of recombinant viruses and virus-like particles, viral evolution, network biology and viruses, and animal models and transgenics, as well as a chapter devoted to HIV and AIDS
• Downloadable artwork, original animations and online resources are available at www.blackwellpublishing.com/wagner

Read More Show Less

Editorial Reviews

From the Publisher
"This latest revision to the very successful Basic Virologyis more than just a simple update… The new chapters are verytimely and address current virology research topics including theimportant issues of molecular pathogenesis and bioinformatics. Thetext is well written and very understandable with excellent use ofphotos, diagrams, and tables to highlight and aid in theunderstanding of difficult issues. Instructors will find the textup to date and the figures readily adaptable to Powerpointlectures. Students will be pleased to find the text engaging whilepresenting virology in a clear, concise, and enjoyablemanner."
Professor Michael R. Roner, University of Texas, Arlington
Booknews
Molecular biologists Wagner (U. of California) and Hewlett (U. of Arizona) basic text written for a one-semester undergraduate course. Material covers basic issues of virology and viral disease, properties of viruses and virus-cell interaction, working with viruses, and replication patterns of specific viruses. Annotation c. Book News, Inc., Portland, OR (booknews.com)
Doody's Review Service
Reviewer: Nancy D. Hanson, PhD (Creighton University)
Description: This book is well designed for undergraduate students interested in understanding basic virology. It does a good job of providing an understanding of other disciplines required to fully appreciate basic virology and is an important update to the first edition which appeared in 1999.
Purpose: The authors are both well known virologists who have an enormous amount of research and undergraduate teaching experience. The purpose of this book is to give the undergraduate student an appreciation for the complexity and disciplines required for the study of virology. The authors meet these objectives, which are critical for the training of future scientists and medical professionals. The generation of information in the field of virology is enormous, thus requiring frequent updates.
Audience: This book is written for undergraduate students who are planning a career in science either as research scientists or health professionals. The authors are well known authorities in the field of virology.
Features: The illustrations, along with an appendix including hard copy and Web-based references and a glossary of terms, make this book particularly appealing for teaching students. The book is very well organized and allows students to progress by learning general concepts first, followed by more complex and detailed concepts on individual groups of viruses. It is particularly nice that the authors make general statements suggesting the simplicity of a system but remind the student in the next sentence the actual complexity of the topic.
Assessment: This book offers an excellent forum for both students and instructors to examine the world of virology. I would not hesitate using this book in an upper level undergraduate class or as a foundation text coupled with current literature for a basic virology course for graduate students.

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9781405147156
  • Publisher: Wiley
  • Publication date: 12/10/2007
  • Edition description: Revised
  • Edition number: 33
  • Pages: 580
  • Sales rank: 924,258
  • Product dimensions: 8.68 (w) x 10.90 (h) x 1.06 (d)

Meet the Author

Edward K. Wagner (May 4, 1940 – January 21, 2006) was Professor of Molecular Biology and Biochemistry at the University of California Irvine. Martinez J. Hewlett is Professor Emeritus in the Department of Molecular and Cellular Biology at the University of Arizona. New to this edition, David C. Bloom is Associate Professor in the Department of Molecular Genetics and Microbiology at University of Florida and David Camerini is Assistant Professor in the Department of Molecular Biology and Biochemistry at the University of California Irvine.

Read More Show Less

Table of Contents

Preface to the First Edition.

Preface to the Second Edition.

Preface to the Third Edition.

Acknowledgments.

Part I: Virology and Viral Disease.

1. Introduction – the Impact of Viruses on Our View ofLife 2.

THE SCIENCE OF VIROLOGY.

The Effect of Virus Infections on the Host Organism andPopulations – Viral Pathogenesis, Virulence, andEpidemiology.

The Interaction Between Viruses and Their Hosts.

The History of Virology.

Examples of the Impact of Viral Disease on Human History.

Examples of the Evolutionary Impact of the Virus–HostInteraction.

The Origin of Viruses.

Viruses Have a Constructive as Well as Destructive Impact onSociety.

Viruses are Not the Smallest Self-replicating Pathogens.

2. An Outline of Virus Replication and Viral Pathogenesis.

VIRUS REPLICATION.

Stages of Virus Replication in the Cell.

PATHOGENESIS OF VIRAL INFECTION.

Stages of Virus-induced Pathology.

3. Virus Disease in Populations and Individual Animals.

THE NATURE OF VIRUS RESERVOIRS.

Some Viruses with Human Reservoirs.

Some Viruses with Vertebrate Reservoirs.

VIRUSES IN POPULATIONS.

Viral Epidemiology in Small and Large Populations.

Factors Affecting the Control of Viral Disease inPopulations.

ANIMAL MODELS TO STUDY VIRAL PATHOGENESIS.

A Mouse Model for Studying Poxvirus Infection and Spread.

Rabies: Where is the Virus During its Long IncubationPeriod?.

Herpes Simplex Virus Latency.

4. Patterns of Some Viral Diseases of Humans.

The Stable Association of Viruses with their Natural Host PlacesSpecific Constraints on the Nature of Viral Disease and Mode ofPersistence.

Classification of Human Disease-Causing Viruses According toVirus–Host Dynamics.

PATTERNS OF SPECIFIC VIRAL DISEASES OF HUMANS.

Acute Infections Followed by Virus Clearing.

Infection of an “Accidental” Target Tissue Leadingto Permanent Damage Despite Efficient Clearing.

Persistent Viral Infections.

Viral and Subviral Diseases with Long Incubation Periods.

SOME VIRAL INFECTIONS TARGETING SPECIFIC ORGAN SYSTEMS.

Viral Infections of Nerve Tissue.

Examples of Viral Encephalitis with Grave Prognosis.

Viral Encephalitis with Favorable Prognosis for Recovery.

Viral Infections of the Liver (Viral Hepatitis).

PROBLEMS FOR PART I.

ADDITIONAL READING FOR PART I.

Part II: Basic Properties of Viruses and Virus–CellInteraction.

5. Virus Structure and Classification.

THE FEATURES OF A VIRUS.

Viral Genomes.

Viral Capsids.

Viral Envelopes.

CLASSIFICATION SCHEMES.

The Baltimore Scheme of Virus Classification.

Disease-based Classification Schemes for Viruses.

THE VIROSPHERE.

6. The Beginning and End of the Virus Replication Cycle.

Outline of the Virus Replication Cycle.

VIRAL ENTRY.

Mechanisms of Entry of Nonenveloped Viruses.

Entry of Enveloped Viruses.

Entry of Virus into Plant Cells.

Injection of Bacteriophage DNA into Escherichia coli.

Nonspecific Methods of Introducing Viral Genomes into Cells.

LATE EVENTS IN VIRAL INFECTION: CAPSID ASSEMBLY AND VIRIONRELEASE.

Assembly of Helical Capsids.

Assembly of Icosahedral Capsids.

Generation of the Virion Envelope and Egress of the EnvelopedVirion.

7. Host Immune Response to Viral Infection – The Nature ofthe Vertebrate Immune Response.

THE INNATE IMMUNE RESPONSE – EARLY DEFENSE AGAINSTPATHOGENS.

Toll-like Receptors.

Defensins.

THE ADAPTIVE IMMUNE RESPONSE AND THE LYMPHATIC SYSTEM.

Two Pathways of Helper T Response: the Fork in the Road.

The Immunological Structure of a Protein.

Role of the Antigen-presenting Cell in Initiation of the ImmuneResponse.

CONTROL AND DYSFUNCTION OF IMMUNITY.

Specific Viral Responses to Host Immunity.

Consequences of Immune Suppression to Virus Infections.

MEASUREMENT OF THE IMMUNE REACTION.

Measurement of Cell-mediated (T-cell) Immunity.

Measurement of Antiviral Antibody.

8. Strategies to Protect Against and Combat Viral Infection.

VACCINATION – INDUCTION OF IMMUNITY TO PREVENT VIRUSINFECTION.

Antiviral Vaccines.

Smallpox and the History of Vaccination.

How a Vaccine is Produced.

Problems with Vaccine Production and Use.

EUKARYOTIC CELL-BASED DEFENSES AGAINST VIRUS REPLICATION.

Interferon.

Other Cellular Defenses against Viral Infection.

ANTIVIRAL DRUGS.

Targeting Antiviral Drugs to Specific Features of the VirusReplication Cycle.

Other Approaches.

BACTERIAL ANTIVIRAL SYSTEMS – RESTRICTIONENDONUCLEASES.

PROBLEMS FOR PART II.

ADDITIONAL READING FOR PART II.

Part III: Working with Virus.

9. Visualization and Enumeration of Virus Particles.

Using the Electron Microscope to Study and Count Viruses.

Atomic Force Microscopy – A Rapid and Sensitive Method forVisualization of Viruses and Infected Cells, Potentially in RealTime.

Indirect Methods for “Counting” Virus Particles.

10. Replicating and Measuring Biological Activity ofViruses.

Cell Culture Techniques.

Culture of Animal and Human Cells.

THE OUTCOME OF VIRUS INFECTION IN CELLS.

Fate of the Virus.

Fate of the Cell Following Virus Infection.

MEASUREMENT OF THE BIOLOGICAL ACTIVITY OF VIRUSES.

Quantitative Measure of Infectious Centers.

Use of Virus Titers to Quantitatively Control InfectionConditions.

Dilution Endpoint Methods.

11. Physical and Chemical Manipulation of the StructuralComponents of Viruses.

Viral Structural Proteins.

Isolation of Structural Proteins of the Virus.

Size Fractionation of Viral Structural Proteins.

CHARACTERIZING VIRAL GENOMES.

Sequence Analysis of Viral Genomes.

Measuring the Size of Viral Genomes.

The Polymerase Chain Reaction – Detection andCharacterization of Extremely Small Quantities of Viral Genomes orTranscripts.

12. Characterization of Viral Products Expressed in the InfectedCell.

CHARACTERIZATION OF VIRAL PROTEINS IN THE INFECTED CELL.

Pulse Labeling of Viral Proteins at Different Times FollowingInfection.

Use of Immune Reagents for Study of Viral Proteins.

DETECTING AND CHARACTERIZING VIRAL NUCLEIC ACIDS IN INFECTEDCELLS.

Characterization of Viral mRNA Expressed During Infection.

USE OF MICROARRAY TECHNOLOGY FOR GETTING A COMPLETE PICTURE OFTHE EVENTS OCCURRING IN THE INFECTED CELL.

13. Viruses Use Cellular Processes to Express Their GeneticInformation.

Prokaryotic DNA Replication is an Accurate Enzymatic Model forthe Process Generally.

Expression of mRNA.

Prokaryotic Transcription.

Eukaryotic Transcription.

The Mechanism of Protein Synthesis.

PROBLEMS FOR PART III.

ADDITIONAL READING FOR PART III.

Part IV: Replication Patterns of Specific Viruses.

14. Replication of Positive-sense RNA Viruses.

RNA VIRUSES – GENERAL CONSIDERATIONS.

A General Picture of RNA-Directed RNA Replication.

REPLICATION OF POSITIVE-SENSE RNA VIRUSES WHOSE GENOMES ARETRANSLATED AS THE FIRST STEP IN GENE EXPRESSION.

POSITIVE-SENSE RNA VIRUSES ENCODING A SINGLE LARGE OPEN READINGFRAME.

Picornavirus Replication.

Flavivirus Replication.

Positive-sense RNA Viruses Encoding More than One TranslationalReading Frame.

Two Viral mRNAs are Produced in Different Amounts DuringTogavirus Infections.

A Somewhat More Complex Scenario of Multiple TranslationalReading Frames and Subgenomic mRNA Expression: CoronavirusReplication.

REPLICATION OF PLANT VIRUSES WITH RNA GENOMES.

Viruses with One Genome Segment.

Viruses with Two Genome Segments.

Viruses with Three Genome Segments.

REPLICATION OF BACTERIOPHAGE WITH RNA GENOMES.

Regulated Translation of Bacteriophage mRNA.

15. Replication Strategies of RNA Viruses Requiring RNA-directedmRNA Transcription as the First Step in Viral Gene Expression.

Paramyxoviruses.

Filoviruses and their Pathogenesis.

Bornaviruses.

INFLUENZA VIRUSES – NEGATIVE-SENSE RNA VIRUSES WITH AMULTIPARTITE GENOME.

Involvement of the Nucleus in Flu Virus Replication.

Generation of New Flu Nucleocapsids and Maturation of theVirus.

Influenza A Epidemics.

OTHER NEGATIVE-SENSE RNA VIRUSES WITH MULTIPARTITE GENOMES.

Bunyaviruses.

Arenaviruses.

VIRUSES WITH DOUBLE-STRANDED RNA GENOMES.

Reovirus Structure.

Reovirus Replication Cycle.

Pathogenesis.

SUBVIRAL PATHOGENS.

Hepatitis Delta Virus.

Viroids.

Prions.

16. Replication Strategies of Small and Medium-sized DNAViruses.

DNA Viruses Express Genetic Information and Replicate TheirGenomes in Similar, Yet Distinct, Ways.

Papovavirus Replication.

Replication of SV40 Virus – The Model Polyomavirus.

Replication of Papillomaviruses.

Replication of Adenoviruses.

Physical Properties of Adenovirus.

The Adenovirus Replication Cycle.

Replication of Some Single-stranded DNA Viruses.

Replication of Parvoviruses.

DNA Viruses Infecting Vascular Plants.

Single-stranded DNA Bacteriophage —X174 Packages itsGenes Very Compactly.

17. Replication of Some Nuclear-replicating Eukaryotic DNAViruses with Large Genomes.

HERPESVIRUS REPLICATION AND LATENCY.

The Herpesviruses as A Group.

The Replication of the Prototypical Alpha-Herpesvirus –HSV.

HSV Latency and LAT.

EBV Latent Infection of Lymphocytes, A Different Set of Problemsand Answers.

Pathology of Herpesvirus Infections.

BACULOVIRUS, AN INSECT VIRUS WITH IMPORTANT PRACTICAL USES INMOLECULAR BIOLOGY.

Virion Structure.

Viral Gene Expression and Genome Replication.

Pathogenesis.

Importance of Baculoviruses in Biotechnology.

18. Replication of Cytoplasmic DNA Viruses and“Large” Bacteriophages.

POXVIRUSES – DNA VIRUSES THAT REPLICATE IN THE CYTOPLASMOF EUKARYOTIC CELLS.

The Pox Virion is Complex and Contains Virus-coded TranscriptionEnzymes.

The Poxvirus Replication Cycle.

Pathogenesis and History of Poxvirus Infections.

Is Smallpox Virus A Potential Biological Terror Weapon?.

REPLICATION OF “LARGE” DNA-CONTAININGBACTERIOPHAGES.

Components of Large DNA-containing Phage Virions.

Replication of Phage T7.

T4 Bacteriophage: the Basic Model for All DNA Viruses.

Replication of Phage —: a “Simple” Model forLatency and Reactivation.

A GROUP OF ALGAL VIRUSES SHARES FEATURES OF ITS GENOME STRUCTUREWITH POXVIRUSES AND BACTERIOPHAGES.

19. Retroviruses: Converting RNA to DNA.

RETROVIRUS FAMILIES AND THEIR STRATEGIES OF REPLICATION.

The Molecular Biology of Retrovirus.

Replication of Retroviruses: An Outline of the ReplicationProcess.

Viral Gene Expression, Assembly, and Maturation.

MECHANISMS OF RETROVIRUS TRANSFORMATION.

Transformation through the Action of A Viral Oncogene – ASubverted Cellular Growth Control Gene.

Oncornavirus Alteration of Normal Cellular TranscriptionalControl of Growth Regulation.

Oncornavirus Transformation by Growth Stimulation of NeighboringCells.

CELLULAR GENETIC ELEMENTS RELATED TO RETROVIRUSES.

Retrotransposons.

The Relationship Between Transposable Elements and Viruses.

20. Human Immunodeficiency Virus Type 1 (HIV-1) and RelatedLentiviruses.

HIV-1 and Related Lentiviruses.

The Origin of HIV-1 and AIDS.

HIV-1 and Lentiviral Replication.

Destruction of the Immune System by HIV-1.

21. Hepadnaviruses: Variations on the Retrovirus Theme.

The Virion and the Viral Genome.

The Viral Replication Cycle.

The Pathogenesis of Hepatitis B Virus.

A Plant “Hepadnavirus”: Cauliflower MosaicVirus.

The Evolutionary Origin of Hepadnaviruses.

PROBLEMS FOR PART IV.

ADDITIONAL READING FOR PART IV.

PART V: Viruses: New Approaches and New Problems.

22. The Molecular Genetics of Viruses.

Mutations in Genes and Resulting Changes to Proteins.

Analysis of Mutations.

Isolation of Mutants.

A TOOL KIT FOR MOLECULAR VIROLOGISTS.

Viral Genomes.

Locating Sites of Restriction Endonuclease Cleavage On the ViralGenome – Restriction Mapping.

Cloning Vectors.

Directed Mutagenesis of Viral Genes.

Generation of Recombinant Viruses.

23. Molecular Pathogenesis.

AN INTRODUCTION TO THE STUDY OF VIRAL PATHOGENESIS.

ANIMAL MODELS.

Choosing a model: Natural Host vs. Surrogate Models.

Development of New Models: Transgenic Animals.

Hybrid Models: the SCID-hu Mouse.

Considerations Regarding the Humane Use of Animals.

METHODS FOR THE STUDY OF PATHOGENESIS.

Assays of Virulence.

Analysis of Viral Spread within the Host.

Resolving the Infection to the Level of Single Cells.

CHARACTERIZATION OF THE HOST RESPONSE.

Immunological Assays.

Use of Transgenic Mice to Dissect Critical Components of theHost Immune Response That Modulate the Viral Infection.

24. Viral Bioinformatics and Beyond.

BIOINFORMATICS.

Bioinformatics and Virology.

BIOLOGICAL DATABASES.

Primary Databases.

Secondary Databases.

Composite Databases.

Other Databases.

BIOLOGICAL APPLICATIONS.

Similarity Searching Tools.

Protein Functional Analysis.

Sequence Analysis.

Structural Modeling.

Structural Analysis.

SYSTEMS BIOLOGY AND VIRUSES.

VIRAL INTERNET RESOURCES.

25. Viruses and the Future – Promises andProblems.

Clouds on the Horizon – Emerging Disease.

What are the Prospects of Using Medical Technology to EliminateSpecific Viral and Other Infectious Diseases?.

Silver Linings – Viruses as Therapeutic Agents.

Why Study Virology?.

PROBLEMS FOR PART V.

ADDITIONAL READING FOR PART V.

Appendix: Resource Center.

Books of Historical and Basic Value.

Books on Virology.

Molecular Biology and Biochemistry Texts.

Detailed Sources.

Sources for Experimental Protocols.

The Internet.

Technical Glossary.

Index

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)