Bayesian Methods and Ethics in a Clinical Trial Design / Edition 1

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This book discusses the ethical considerations of Bayesian methods applied to clinical trial design. It is comprised of essays written not only by statisticians, but also by scholars in philosophy, law, medicine and statistical computing.
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Editorial Reviews

From the Publisher
"...Every practitioner and associated statistician involved in a clinical trial should read this book..." (Statistical Methods in Medical Research, No.11, 2002)
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Product Details

  • ISBN-13: 9780471846802
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/25/1996
  • Series: Wiley Series in Probability and Statistics Series , #214
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 344
  • Product dimensions: 6.36 (w) x 9.65 (h) x 0.95 (d)

Meet the Author

JOSEPH B. KADANE is Leonard J. Savage Professor of Statistics and Social Sciences at Carnegie Mellon University. He has published over one hundred papers on statistical theory and applications, edited the book Robustness of Bayesian Analysis, and coedited Statistics and the Law.
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Table of Contents

About the Authors
1 Introduction 3
2 Ethically Optimizing Clinical Trials 19
3 Admissibility of Treatments 65
4 Statistical Issues in the Analysis of Data Gathered in the New Designs 115
5 Introduction to the Verapamil/Nitroprusside Study 129
6 The Mechanics of Conducting a Clinical Trial 131
7 The Verapamil/Nitroprusside Study: Comments on "The Mechanics of Conducting a Clinical Trial" 145
8 Computational Aspects of the Verapamil/Nitroprusside Study 151
9 Being an Expert 159
10 Issues of Statistical Design 163
11 Operational History and Procedural Feasibility 171
12 Verapamil versus Nitroprusside: Results of the Clinical Trial I 177
13 Verapamil versus Nitroprusside: Results of the Clinical Trial II 211
14 The Law of Clinical Testing with Human Subjects: Legal Implications of the New and Existing Methodologies 223
15 Commentary I on "The Law of Clinical Testing with Human Subjects" 251
16 Commentary II on "The Law of Clinical Testing with Human Subjects" 257
17 Author's Response to Commentaries I and II 263
18 Whether to Participate in a Clinical Trial: The Patient's View 267
19 Epilogue 309
Name Index 311
Subject Index 315
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