Behavioral Neurobiology of Depression and Its Treatment

Overview

The book highlights important new research using current state-of- the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in ...

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Overview

The book highlights important new research using current state-of- the-art approaches by prominent researchers in the field of depression. A broad range of topics is covered, beginning with a description of the phenotypic features of clinical depression, followed by chapters on the cellular and molecular basis, functional neuroimaging correlates and information-processing accounts. Finally, existing and novel treatment approaches are covered. In this way the volume brings together the key disciplines involved in the neurobiological understanding of depression to provide an update of the field and outlook to the future. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of depression research.

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Editorial Reviews

Doody's Review Service
Reviewer: Michael Joel Schrift, D.O., M.A.(University of Illinois at Chicago College of Medicine)
Description: Despite the tremendous advances in the understanding of brain mechanisms involved in mood regulation, very little of this knowledge has translated into better treatments. There has been no real improvement in the treatment of depression over the past several decades. The SSRIs have turned out to be placebo-level antidepressants, as have rTMS and vagal nerve stimulation. Deep brain stimulation is still at the research stage and not ready for prime time. This book addresses the recent advances in the neurobiological understanding of mood and how that neurobiology changes with depression.
Purpose: The goal of the book, as stated by the editors, "is to bring together scholarly reviews from experts working across these disciplines (behavioral neuroscience)."
Audience: The intended audience includes researchers and clinicians in the field.
Features: The first two parts of the book focus on the clinical features of depression as well as the molecular mechanisms and cellular physiology involved. Part 3 contains interesting chapters on emotional processing and antidepressants, and fear and reward learning. The last part covers treatments, but with significant omissions. I find it quite disheartening that a book covering the neurobiology of depression, written by well-known clinician-researchers in the field, does not even mention electroconvulsive therapy. There is a chapter on neurosurgical treatments with discussions of vagal nerve stimulation and deep brain stimulation, but yet the most well-known efficacious treatment in psychiatry in general or for depression specifically, is not discussed at all!
Assessment: Written and edited by internationally recognized clinician-researchers in the field, I have many concerns about this book and, unfortunately I cannot recommend it, except for several of the chapters. It is a mediocre (at best) book on depression and some of its treatments.
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Product Details

  • ISBN-13: 9783642354243
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 4/30/2013
  • Series: Current Topics in Behavioral Neurosciences Series , #14
  • Edition description: 2013
  • Edition number: 1
  • Pages: 344
  • Product dimensions: 6.00 (w) x 9.20 (h) x 1.00 (d)

Table of Contents

Preface.- Part 1. Phenotypic features.-Classification of mood disorders.Developmental aspects of depression.Animal models of depression vulnerability.Genetic mouse models of depression.-Part 2. Cellular and Molecular Basis.- The Genetic basis of depression. Neurochemical Imaging and Depressive Behaviours.Inflammation and Depression. Major Depression: A Role for Hippocampal Neurogenesis? Neurobiological Markers of Familial Risk for Depression.-Part 3. Cognitive accounts.-Emotional Processing and Antidepressant Action. What Can Fear and Reward Learning Teach Us About Depression? The Use of Cognitive Bias Modification and Imagery in the Understanding and Treatment of Depression.-Part 4. Treatment.-Pharmacological Treatment of Unipolar Depression.New Approaches in the Treatment of Bipolar Depression.Molecular and Cellular Mechanisms of Antidepressant Action. Neurosurgical treatments of depression - clinical and preclinical studies.

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