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The Behavioral Neurology of Dementia

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Overview

The Behavioral Neurology of Dementia is a comprehensive textbook that offers a unique and modern approach to the diagnosis and treatment of patients with dementing conditions. The coverage is broad, ranging from common conditions such as Alzheimer's disease, parkinsonian disorders, vascular and frontotemporal dementia, to the more obscure such as Creutzfeldt-Jakob disease, Subtypes of mild cognitive impairment are presented and the early prodromes of Alzheimer's disease, vascular disease, parkinsonian disorders and frontotemporal dementia are explored from the perspective of mild cognitive impairment. Simple approaches to bedside mental status testing, differential diagnosis and treatment, genetic testing, interpreting neuropsychological testing and neuroimaging findings, and assessing rapidly progressive dementias, paraneoplastic syndromes, and disorders of white matter give guidance to both the novice and expert in dementia. The basic science of dementia is outlined in introductory chapters on animal models of dementia, dementia epidemiology, and dementia neuropathology. The Behavioral Neurology of Dementia is edited by two leading authorities in the field of dementia and written by an international group of opinion-leaders from the United States, Europe, and Asia, who provide a truly comprehensive coverage of dementia for the twenty-first century.

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Editorial Reviews

Doody's Review Service
Reviewer: Bryan Woodruff, MD (Mayo Clinic Arizona)
Description: This comprehensive overview of the various dementia syndromes includes practical information on clinical management as well as current research trends.
Purpose: It describes a modern approach to the evaluation of not only common causes of dementia such as Alzheimer's disease and Parkinsonian disorders, but also the less common entities such as Creutzfeldt-Jakob disease and dementia mimics. The introductory section also covers important basic neuroscience approaches to dementia, including neurogenetics, neuroimaging, neuropathology, and epidemiology. Including such diverse topics in a single book is a worthy goal, and the authors succeed while maintaining a cohesive theme throughout.
Audience: According to the authors, the book is designed to be a guide "to both the novice and expert" in dementia. Though many chapters provide straightforward information useful to nonspecialists caring for dementia patients, certain sections are somewhat technically dense and less practical, though certainly of interest to experts in the field. The authors are esteemed leaders in the field of dementia care and research.
Features: The book comprehensively covers the major dementia syndromes, including Alzheimer's disease, Parkinsonian disorders (dementia with Lewy bodies, Parkinson's disease with dementia, progressive supranuclear palsy, and corticobasal degeneration), vascular dementia, subtypes of frontotemporal dementia including the progressive aphasias, and rare forms of dementia such as Creutzfeldt-Jakob disease. The prodromal phase of dementia, mild cognitive impairment, is also covered, as are the active areas of research in the field of dementia such as neuroimaging techniques as well as neurogenetics and animal model approaches to identify more effective therapies for dementia. The chapters on neurogenetics, neuroimaging, and neuropathology are particularly informative, covering complex topics in an approachable fashion. Organizing the book into chapters on certain disorders or aspects of assessment allows readers to quickly find areas of interest, but unfortunately introduces some redundancy. However, the order of the chapters is somewhat atypical — novices in dementia would likely prefer to see high-yield topics such as mild cognitive impairment and Alzheimer's disease early in the book, but the introductory chapter is followed instead by a chapter on dementia with Lewy bodies and then a review of the neurogenetics of dementia.
Assessment: This is an authoritative and comprehensive review of topics for clinicians seeing patients with both common and rare presentations of dementia. Though the organization of the book could be better and there is some repetition, overall this is a valuable clinical resource. Topics often neglected in behavioral neurology books are covered here, such as the later chapters reviewing dementia mimics and the recognition and management of delirium.
From The Critics
Reviewer:Bryan Woodruff, MD(Mayo Clinic Hospital)
Description:This comprehensive overview of the various dementia syndromes includes practical information on clinical management as well as current research trends.
Purpose:It describes a modern approach to the evaluation of not only common causes of dementia such as Alzheimer's disease and Parkinsonian disorders, but also the less common entities such as Creutzfeldt-Jakob disease and dementia mimics. The introductory section also covers important basic neuroscience approaches to dementia, including neurogenetics, neuroimaging, neuropathology, and epidemiology. Including such diverse topics in a single book is a worthy goal, and the authors succeed while maintaining a cohesive theme throughout.
Audience:According to the authors, the book is designed to be a guide "to both the novice and expert" in dementia. Though many chapters provide straightforward information useful to nonspecialists caring for dementia patients, certain sections are somewhat technically dense and less practical, though certainly of interest to experts in the field. The authors are esteemed leaders in the field of dementia care and research.
Features:The book comprehensively covers the major dementia syndromes, including Alzheimer's disease, Parkinsonian disorders (dementia with Lewy bodies, Parkinson's disease with dementia, progressive supranuclear palsy, and corticobasal degeneration), vascular dementia, subtypes of frontotemporal dementia including the progressive aphasias, and rare forms of dementia such as Creutzfeldt-Jakob disease. The prodromal phase of dementia, mild cognitive impairment, is also covered, as are the active areas of research in the field of dementia such as neuroimaging techniques as well as neurogenetics and animal model approaches to identify more effective therapies for dementia. The chapters on neurogenetics, neuroimaging, and neuropathology are particularly informative, covering complex topics in an approachable fashion. Organizing the book into chapters on certain disorders or aspects of assessment allows readers to quickly find areas of interest, but unfortunately introduces some redundancy. However, the order of the chapters is somewhat atypical -- novices in dementia would likely prefer to see high-yield topics such as mild cognitive impairment and Alzheimer's disease early in the book, but the introductory chapter is followed instead by a chapter on dementia with Lewy bodies and then a review of the neurogenetics of dementia.
Assessment:This is an authoritative and comprehensive review of topics for clinicians seeing patients with both common and rare presentations of dementia. Though the organization of the book could be better and there is some repetition, overall this is a valuable clinical resource. Topics often neglected in behavioral neurology books are covered here, such as the later chapters reviewing dementia mimics and the recognition and management of delirium.
From the Publisher
"This is an authoritative and comprehensive review of topics for clinicians seeing patients with both common and rare presentations of dementia."
—Doody's Review Service
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Product Details

  • ISBN-13: 9780521853958
  • Publisher: Cambridge University Press
  • Publication date: 5/28/2009
  • Pages: 418
  • Product dimensions: 7.90 (w) x 9.80 (h) x 1.20 (d)

Meet the Author

Bruce L. Miller is Professor of Neurology and Psychiatry at the UCSF School of Medicine, San Francisco, California, USA.

Bradley F. Boeve is Associate Professor of Neurology at the Mayo Clinic, Rochester, Minnesota, USA.

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Table of Contents

List of contributors vii

Section 1 Introduction 1

1 Basic clinical approaches to diagnosis Bruce L. Miller 1

2 Dementia with Lewy bodies Caroline A. Racine 7

3 Neurogenetics of dementia Huidy Shu 27

4 Frontotemporal dementia Indre V. Viskontas Bruce L. Miller 45

5 Alzheimer's disease Brandy R. Matthews Bruce L. Miller 56

6 Mental status examination Casey E. Krueger Joel H. Kramer 74

7 Neuropsychiatric features of dementia Edmond Teng Gad A. Marshall Jeffrey L. Cummings 85

8 Neuroimaging in dementia Maria Carmela Tartaglia Howard Rosen 101

9 Epidemiology and risk factors Kristine Yaffe Deborah E. Barnes 120

10 Animal models of dementia Erik D. Roberson Aimee W. Kao 131

11 Neuropathology of dementia Marcelo N. Macedo Eun-Joo Kim William W. Seeley 142

Section 2 Cognitive impairment, not demented 161

12 Cerebrovascular contributions to amnestic mild cognitive impairment Charles DeCarli Adriane Votaw Mayda Christine Wu Nordahl 161

13 Mild cognitive impairment Brendan J. Kelley Ronald C. Petersen 172

14 Mild cognitive impairment subgroups Julene K. Johnson 188

15 Early clinical features of the parkinsonian-related dementias Bradley F. Boeve 197

16 Dementia treatment Bradley F. Boeve Adam L. Boxer 213

17 Dementia and cognition in the oldest-old Kristin Kahle-Wrobleski María M. Corrada Claudia H. Kawas 254

Section 3 Slowly progressive dementias 264

18 Semantic dementia John R. Hodges R. Rhys Davies Karalyn Patterson 264

19 Progressive non-fluent aphasia Jennifer Ogar Maria Luisa Gorno-Tempini 279

20 Cognition in corticobasal degeneration and progressive supranuclear palsy Paul McMonagle Andrew Kertesz 288

21 Cognitive and behavioralabnormalities of vascular dementia Jee H. Jeong Eun-Joo Kim Sang Won Seo Duk L. Na 302

22 CADASIL: a genetic model of arteriolar degeneration, white matter injury and dementia in later life Stephen Salloway Thea Brennan-Krohn Stephen Correia Michelle Mellion Suzanne delaMonte 329

Section 4 Rapidly progressive dementias 345

23 Prion disorders and other rapidly progressive dementias Michael D. Geschwind Aissa Haman Indre V. Viskontas 345

24 Delirium masquerading as dementia S. Andrew Josephson 367

25 Paraneoplastic disorders of the memory and cognition Luis Bataller Josep Dalmau 377

Index 395

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