The Behavioral Neurology of Dementia

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The Behavioral Neurology of Dementia is a comprehensive textbook that offers a unique and modern approach to the diagnosis and treatment of patients with dementing conditions in the twenty-first century. The coverage is broad, ranging from common conditions such as Alzheimer's disease, Parkinsonian disorders, vascular and frontotemporal dementia, to the more obscure such as Creutzfeldt–Jakob disease. Subtypes of mild cognitive impairment are presented and the early prodromes of neurodegenerative diseases are explored. Simple approaches to bedside mental status testing, differential diagnosis and treatment, genetic testing, interpreting neuropsychological testing and neuroimaging findings, and assessing rapidly progressive dementias, paraneoplastic syndromes and disorders of white matter give guidance to both the novice and expert in dementia. The basic science of dementia is outlined in introductory chapters on animal models of dementia, dementia epidemiology and dementia neuropathology.

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Editorial Reviews

From the Publisher
"This is an authoritative and comprehensive review of topics for clinicians seeing patients with both common and rare presentations of dementia."
—Doody's Review Service
Doody's Review Service
Reviewer: Bryan Woodruff, MD (Mayo Clinic Arizona)
Description: This comprehensive overview of the various dementia syndromes includes practical information on clinical management as well as current research trends.
Purpose: It describes a modern approach to the evaluation of not only common causes of dementia such as Alzheimer's disease and Parkinsonian disorders, but also the less common entities such as Creutzfeldt-Jakob disease and dementia mimics. The introductory section also covers important basic neuroscience approaches to dementia, including neurogenetics, neuroimaging, neuropathology, and epidemiology. Including such diverse topics in a single book is a worthy goal, and the authors succeed while maintaining a cohesive theme throughout.
Audience: According to the authors, the book is designed to be a guide "to both the novice and expert" in dementia. Though many chapters provide straightforward information useful to nonspecialists caring for dementia patients, certain sections are somewhat technically dense and less practical, though certainly of interest to experts in the field. The authors are esteemed leaders in the field of dementia care and research.
Features: The book comprehensively covers the major dementia syndromes, including Alzheimer's disease, Parkinsonian disorders (dementia with Lewy bodies, Parkinson's disease with dementia, progressive supranuclear palsy, and corticobasal degeneration), vascular dementia, subtypes of frontotemporal dementia including the progressive aphasias, and rare forms of dementia such as Creutzfeldt-Jakob disease. The prodromal phase of dementia, mild cognitive impairment, is also covered, as are the active areas of research in the field of dementia such as neuroimaging techniques as well as neurogenetics and animal model approaches to identify more effective therapies for dementia. The chapters on neurogenetics, neuroimaging, and neuropathology are particularly informative, covering complex topics in an approachable fashion. Organizing the book into chapters on certain disorders or aspects of assessment allows readers to quickly find areas of interest, but unfortunately introduces some redundancy. However, the order of the chapters is somewhat atypical — novices in dementia would likely prefer to see high-yield topics such as mild cognitive impairment and Alzheimer's disease early in the book, but the introductory chapter is followed instead by a chapter on dementia with Lewy bodies and then a review of the neurogenetics of dementia.
Assessment: This is an authoritative and comprehensive review of topics for clinicians seeing patients with both common and rare presentations of dementia. Though the organization of the book could be better and there is some repetition, overall this is a valuable clinical resource. Topics often neglected in behavioral neurology books are covered here, such as the later chapters reviewing dementia mimics and the recognition and management of delirium.
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Product Details

  • ISBN-13: 9781107629998
  • Publisher: Cambridge University Press
  • Publication date: 3/17/2011
  • Pages: 418
  • Product dimensions: 7.40 (w) x 9.60 (h) x 0.80 (d)

Meet the Author

Bruce L. Miller is Professor of Neurology and Psychiatry at the UCSF School of Medicine, San Francisco, California, USA.

Bradley F. Boeve is Associate Professor of Neurology at the Mayo Clinic, Rochester, Minnesota, USA.

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Table of Contents

Contents; List of contributors; Preface; Part I. Introduction: 1. Basic clinical approaches to diagnosis Bruce L. Miller; 2. Neurogenetics of dementia Huidy Shu; 3. Frontotemporal dementia Indre Viskontas and Bruce L. Miller; 4. Alzheimer's disease Brandy J. Matthews and Bruce L. Miller; 5. Mental status examination Casey E. Krueger and Joel H. Kramer; 6. Neuropsychiatric features of dementia Edmond Teng, Gad A. Marshall and Jeffrey L. Cummings; 7. Neuroimaging in dementia Maria Carmela Tartaglia and Howard Rosen; 8. Epidemiology and risk factors Kristine Yaffe and Deborah E. Barnes; 9. Animal models of dementia Erik D. Roberson and Aimee W. Kao; 10. Neuropathology of dementia Marcelo N. Macedo, Eun-Joo Kim and William W. Seeley; Part II. Cognitive Impairment, Not Demented: 11. Cerebrovascular contributions to amnestic mild cognitive impairment Charles DeCarli, Adriane Votaw Mayda and Christine Wu Nordahl; 12. Mild cognitive impairment Brendan J. Kelley and Ronald C. Petersen; 13. Mild cognitive impairment (MCI) subgroups Julene K. Johnson; 14. Early clinical features of the Parkinsonian-related dementias Bradley F. Boeve; 15. Dementia treatment Bradley F. Boeve and Adam L. Boxer; 16. Dementia and cognition in the oldest-old Kristin Kahle-Wrobleski, María M. Corrada and Claudia H. Kawas; Part III. Slowly Progressive Dementias: 17. Semantic dementia John R. Hodges, R. Rhys Davies and Karalyn Patterson; 18. Progressive non-fluent aphasia Jennifer Ogar and Marilu L. Gorno-Tempini; 19. Cognition in corticobasal degeneration and progressive supranuclear palsy Paul McMonagle and Andrew Kertesz; 20. Cognitive and behavioral abnormalities of vascular dementia Jee H. Jeong, Eun-Joo Kim, Sang Won Seo and Duk L. Na; 21. CADASIL: a genetic model of arteriolar degeneration, white matter injury, and dementia in later life Stephen Salloway, Thea Brennan-Krohn, Stephen Correia, Michelle Mellion and Suzanne delaMonte; Part IV. Rapidly Progressive Dementias: 22. Prion disorders and other rapidly progressive dementias Michael D. Geschwind, Aissa Haman and Indre Viskontas; 23. Delirium masquerading as dementia S. Andrew Josephson; 24. Paraneoplastic disorders of the memory and cognition Luis Bataller and Josep Dalmau; 25. Dementia with Lewy bodies Caroline A. Racine; Index.

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