Behavioral Neuroscience of Drug Addiction / Edition 1

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More About This Textbook


The Behavioral Neuroscience of Drug Addiction highlights important new research using current state-of-the-art approaches by prominent neuroscientists in the addiction field. The preclinical chapters describe animal models used to study the neuroanatomical and neurotransmitter systems implicated in drug craving, neuroplasticity in synaptic physiology associated with drug use, and the role of sensitization and withdrawal processes in addictive behavior. Chapters on human studies emphasize neuroimaging of neurotransmitter and receptor levels in drug-addicted patients, brain responses to drug craving and other cognitive abnormalities. These human studies chapters also describe work on genetic vulnerability to drug addiction, the neuroeconomics of drug consumption, and novel pharmacological approaches to drug abuse treatment. Multiple lines of human and animal research coverage to suggest a growing consensus of neurobiological and behavioural change, while other areas require further work to reconcile important differences and establish mechanistic links. Together, the volume chapters provide focused and critical reviews that span a broad range of topics suitable for both students and established investigators interested in the present state of drug addiction research.

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Product Details

  • ISBN-13: 9783642030000
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 1/1/2010
  • Series: Current Topics in Behavioral Neurosciences Series , #3
  • Edition description: 2010
  • Edition number: 1
  • Pages: 392
  • Product dimensions: 6.30 (w) x 9.20 (h) x 1.10 (d)

Table of Contents

Part I Preclinical Neuroscience

Neuroplastic Alterations in the Limbic System Following Cocaine or Alcohol Exposure Garret D. Stuber F. Woodward Hopf Kay M. Tye Billy T. Chen Antonello Bonci 3

Dopamine Signaling in the Nucleus Accumbens of Animals Self-Administering Drugs of Abuse Ingo Willuhn Matthew J. Wanat Jeremy J. Clark Paul E.M. Phillips 29

Amygdala Mechanisms of Pavlovian Psychostimulant Conditioning and Relapse Deanne M. Buffalari Ronald E. See 73

Prefrontal Cortical Regulation of Drug Seeking in Animal Models of Drug Relapse Heather C. Lasseter Xiaohu Xie Donna R. Ramirez Rita A. Fuchs 101

Neural Substrates of Psychostimulant Withdrawal-Induced Anhedonia Manoranjan S. D'Souza Athina Markou 119

Sensitization Processes in Drug Addiction Louk J.M.J. Vanderschuren R. Christopher Pierce 179

Part II Clinical Neuroscience

Imaging Receptor Changes in Human Drug Abusers Kelly P. Cosgrove 199

Imaging Neurotransmitter Release by Drugs of Abuse Diana Martinez Rajesh Narendran 219

Imaging Cognitive Deficits in Drug Abuse Thomas Lundqvist 247

Neural Markers of Genetic Vulnerability to Drug Addiction Daniel J. Müller Olga Likhodi Andreas Heinz 277

The Role of Executive Control in Human Drug Addiction Robert Hester Dan I. Lubman Murat Yücel 301

The Behavioral Economics of Drug Dependence: Towards the Consilience of Economics and Behavioral Neuroscience Warren K. Bickel Richard Yi E. Terry Mueller Bryan A. Jones Darren R. Christensen 319

Novel Pharmacological Approaches to Drug Abuse Treatment Ellen Edens Alfredo Massa Ismene Petrakis 343

Index 387

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