Description: This book synthesizes newly acquired data pertaining to the B3 adrenergic receptor and the potential clinical utility of specific pharmaceuticals designed to interact with this receptor. The first chapter describes what is currently known about the B-adrenergic receptors and the data that were reported describing the discovery of the B3 adrenoreceptor. The second chapter describes thermogenesis and how the B3 receptor mediates it. Chapter 3 describes obesity and abnormalities of thermogenesis. The following chapters describe the pharmacology of the B3 receptor and its various categories of antagonists.
Purpose: The purpose is to describe the B3 adrenoreceptor and potential clinical applications of pharmaceuticals designed to stimulate this receptor.
Audience: The audience this book is aimed at is primarily scientists interested in the fundamental mechanisms of obesity and pharmacologists seeking to achieve active control of thermogenesis and body weight regulation. Secondary audiences would consist of clinicians seeking to understand new agents regulating body weight.
Features: The book includes many figures that present current pharmaceutical data. There are a few graphic models of the metabolic system under study. It would be helpful if these model figures could have been more widely distributed through the text.
Assessment: This is a very useful book to the specialist in this field. The scarcity of figures presenting the biological model under discussion in each chapter is a hindrance. A closing chapter summarizing the field and predicting future avenues of investigation would have completed the book.