Beyond the Synapse: Cell-Cell Signaling in Synaptic Plasticity

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Formation of synapses and the changes in their connections during life are the basis for learning and memory and recovery from brain disease or injury. Much interest has been focused on how synapses function at the molecular level, while the cell-cell interactions controlling the formation receive far less attention. This book expands the scope of inquiry beyond the synaptic cleft to provide a comprehensive insight into how intercellular signalling enables neurons to communicate beyond the synapse, and to interact with other cells in the brain to alter synaptic connections appropriately. There are chapters devoted to consideration of glia, brain cells which have thus far been ignored in the majority of studies of learning and memory. Writing for academic researchers and professionals, contributors to this book reveal that there is much to learning and memory that lies beyond the synapse.

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Editorial Reviews

From the Publisher
Review of the hardback: 'The whole work, with its glossy hard boards and excellent illustrations, is well produced. … This fine survey will tell you all you could wish to know about what goes on between the neurons.' Biologist
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Product Details

  • ISBN-13: 9780521869140
  • Publisher: Cambridge University Press
  • Publication date: 9/15/2008
  • Pages: 320
  • Product dimensions: 7.60 (w) x 9.70 (h) x 0.80 (d)

Meet the Author

Doug Fields has worked at the NIH since 1987, where he now runs the Nervous System Development and Plasticity section. Originally a marine biologist, Dr Fields' primary research interests have always been based around the synapse. He is currently Editor-in-Chief of Neuron Glia Biology.

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Table of Contents

Introduction Beyond the synapse R. Douglas Fields Fields, R. Douglas 1

I Spanning Scales of Neural Plasticity 5

1 Memory beyond the synapse Steven P. R. Rose Rose, Steven P. R. 7

2 Between synapses and behavior: functional circuitry of the hippocampus Howard Eichenbaum Eichenbaum, Howard 14

3 Widening the lens: looking beyond the synapse for experience-driven brain plasticity Julie A. Markham Markham, Julie A. Aaron W. Grossman Grossman, Aaron W. William T. Greenough Greenough, William T. 22

4 Activity-dependent myelination R. Douglas Fields Fields, R. Douglas 36

5 Bipolar disorder: involvement of signaling cascades and AMPA receptor trafficking at synapses Jing Du Jing, Du Jorge Quiroz Quiroz, Jorge Peixiong Yuan Yuan, Peixiong Carlos Zarate, Jr. Zarate, Carlos, Jr. Husseini K. Manji Manji, Husseini K. 43

II Novelty, Stress, and Hormones in Plasticity 57

6 Sleep-dependent memory consolidation and reconsolidation Matthew P. Walker Walker, Matthew P. Robert Stickgold Stickgold, Robert 59

7 Consolidation and reconsolidation of Pavlovian fear-conditioning: roles for intracellular signaling and extracellular modulation in memory storage Christopher Cain Cain, Christopher Jacek Debiec Debiec, Jacek Joseph E. Ledoux Ledoux, Joseph E. 72

8 Emotional and cognitive reinforcement of rat hippocampal long-term potentiation by different learning paradigms Volker Korz Korz, Volker Julietta U. Frey Frey, Julietta U. 80

9 Estrogen and hippocampal synaptic plasticity Michael Foy Foy, Michael Michael Baudry Baudry, Michael Richard F. Thompson Thompson, Richard F. 97

10 Steroid-induced hippocampal synaptic plasticity: sex differences and similarities Russell D.Romeo Romeo, Russell D. Elizabeth M. Waters Waters, Elizabeth M. Bruce S. McEwen McEwen, Bruce S. 111

III Cell-Cell Signaling Molecules in Synaptic Plasticity 121

11 MHC class I in activity-dependent structural and functional plasticity Lisa M. Boulanger Boulanger, Lisa M. 123

12 Cytokine induction of neuronal receptor trafficking: relevance to synaptic function and excitotoxicity Dmitri Leonoudakis Leonoudakis, Dmitri Steven P. Braithwaite Braithwaite, Steven P. Michael S. Beattie Beattie, Michael S. Eric C. Beattie Beattie, Eric C. 130

13 Neurotrophin signaling among neurons and glia during formation of synapses Sarina B. Elmariah Elmariah, Sarina B. Ethan G. Hughes Hughes, Ethan G. Eun Joo Oh Oh, Eun Joo Rita J. Balice-Gordon Balice-Gordon, Rita J. 142

14 Regulation of neurogenesis by neurotrophins: implications in hippocampus-dependent memory Bai Lu Bai, Lu Jay H. Chang Chang, Jay H. 153

15 Focal adhesion-like processes underlie induction of long-term potentiation in the Schaffer collateral-CA1 region of the hippocampus Richard D. Lebaron Lebaron, Richard D. Ruben V. Hernandez Hernandez, Ruben V. Mary M. Navarro Navarro, Mary M. James E. Orfila Orfila, James E. Lisa R. Curry Curry, Lisa R. Joe L. Martinez, Jr. Martinez, Joe L., Jr. 160

16 Signaling to the nucleus in long-term memory Olena Bukalo Bukalo, Olena R. Douglas Fields Fields, R. Douglas 169

IV Non-Traditional Transmitters and Glia 179

17 Diffusible hydrogen peroxide generated by synaptic activity inhibits axonal dopamine release in striatum Marat V. Avshalumov Avshalumov, Marat V. Jyoti C. Patel Patel, Jyoti C. Di Bao Duncan G. MacGregor MacGregor, Duncan G. Zsuzsanna Sidlo Sidlo, Zsuzsanna Margaret E. Rice Rice, Margaret E. 181

18 D-serine as a putative glial neurotransmitter Asif K. Mustafa Mustafa, Asif K. Paul M. Kim Kim, Paul M. Solomon H. Snyder Snyder, Solomon H. 193

19 A dialogue between glia and neurons in the retina: modulation of neuronal excitability Eric A. Newman Newman, Eric A. 201

20 Metabotropic glutamate receptors as a target for astrocytic control of inhibitory synaptic transmission in the hippocampus Wing-Song Liu Liu, Wing-Song Qiwu Xu Xu, Qiwu Jian Kang Jian, Kang Maiken Nedergaard Nedergaard, Maiken 210

References 219

Index 304

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