Bio-Nanomaterials: Designing Materials Inspired by Nature

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Bio-nanotechnology covers the development of novel techniques and materials by making use of the inspiration derived from biomolecular structures and processes.

The progress in molecular biology and microbiology over the past 50 years has provided a solid basis for such development.

Well characterized natural biomolecules as well as tailored recombinant proteins and tailored microorganisms obtained by genetic engineering provide a large ...

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Bio-nanotechnology covers the development of novel techniques and materials by making use of the inspiration derived from biomolecular structures and processes.

The progress in molecular biology and microbiology over the past 50 years has provided a solid basis for such development.

Well characterized natural biomolecules as well as tailored recombinant proteins and tailored microorganisms obtained by genetic engineering provide a large "toolbox" for the implementation of biological structures in a technical environment. Biologically inspired materials engineering enables,
for example, the preparation of living tissue for regenerative bone therapy and the biologically controlled mineralization of precious metal catalysts via immobilized microorganisms.

Written by authors from different fields to reflect the interdisciplinary nature of the topic, this book guides the reader through novel nano-materials processing inspired by nature. The presentation is structured around general principles in seven chapters, each composed of three parts:

(1) biological case studies providing the motivation,
(2) elucidation of the particular principle,
(3) applications related to materials processing.

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Product Details

  • ISBN-13: 9783527410156
  • Publisher: Wiley
  • Publication date: 7/22/2013
  • Edition number: 1
  • Pages: 470
  • Product dimensions: 6.90 (w) x 9.70 (h) x 1.10 (d)

Meet the Author

Wolfgang Pompe is retired professor of Materials Science at theTechnische Universität Dresden, Germany. Having obtained hisacademic degrees in physics, he spent his main academic career inthe Institute of Solid State Physics and Materials Research Dresdenof the Academy of Sciences of the GDR, and since 1991 at theTechnische Universität, with a 1.5 year stay as a visitingprofessor at the University of California Santa Barbara, USA.

Gerhard Rödel is Head of the Institute of Genetics at theTechnische Universität Dresden. He obtained his academicdegrees from the Ludwig-Maximilians-Universität München,Germany, where he worked as Post-doc before taking up theappointment for a professorship in Molecular Biology and GeneralPathology at the Univerisity Ulm, Germany. In 1994, ProfessorRödel was appointed as Professor of Genetics at the TechnischeUniversität Dresden. Since 2006 he is Speaker of the DresdenInternational Graduate School for Biomedicine andBioengineering.

Michael Mertig is head of the "BioNanotechnology and StructureFormation Group" at the Max Bergmann Center of Biomaterials atDresden University of Technology. Having obtained his academicdegrees in physics at Dresden University of Technology, he spentmost of his career in low-temperature physics and nanotechnology.He started to work in the field of bionanotechnology in 1994.

Hans-Jürgen Weiss has worked as a physicist in materialsscience at the Institute of Solid State Physics and MaterialsResearch Dresden and at the Fraunhofer Institute of Materials andBeam Technology Dresden. He has approached various phenomena infossils from a materials science viewpoint in order to obtain newinsight in the sequence of fossilisation processes.

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Table of Contents

Preface IX

1 Molecular Units 1

1.1 Case Studies 1

1.1.1 Nucleic Acids 4

1.1.2 Proteins 11

1.1.3 Carbohydrates 20

1.1.4 Lipids 25

1.2 Basic Principles 27

1.2.1 The Persistence Lengths of Biopolymer Chains 27

1.2.2 Equilibrium Shape of a Semiflexible Polymer Chain 30

1.2.3 The Load–Extension Diagram of a Semiflexible PolymerChain 31

1.2.4 Cooperativity 37

1.2.5 Protein Folding 39

1.2.6 DNA Melting Transition 46

1.2.7 Biocatalytic Reactions 46

1.3 Bioengineering 51

1.3.1 Biointerfacing 51

1.3.2 DNA-Based Nanotechnology 54 Biomolecular Templates for Submicrometer ElectronicCircuitries 54 DNA-Based Nanoprobes 85

1.3.3 Protein-Based Nanotechnology 97

References 104

2 Molecular Recognition 109

2.1 Case Study 109

2.2 Basic Principles 112

2.2.1 Complementary Interaction between Proteins and Ligands113

2.2.2 Cooperative Protein–Ligand Interaction 114

2.2.3 The Enzyme-Linked Immunosorbent Assay 116

2.3 Engineering of Biomolecular Recognition Systems 119

2.3.1 Engineering of Protein-Based Bioaffine Materials 119 Interfacing Mechanisms of Proteins via Bioaffinity119

2.3.2 Engineering of Sensing Biofunctionalized Materials 127 Design Principles of Biosensors 128 Integration of Sensing Biological Elements andTransducer Units 129

References 147

3 Cell Adhesion 149

3.1 Case Study 150

3.2 Basic Principles 154

3.2.1 The Cellular Mechanotransduction System 154

3.2.2 Mechanical Impact of the ECM on Cell Development 158

3.2.3 Influence of the Microenvironment Topology on the CellSpreading and Development 162

3.3 Bioengineering 164

3.3.1 The Basic Approach and Goals 164

3.3.2 Tailored Surfaces for In Vitro Culturing of Cells 168 A Modular Polymer Platform for Mechanically RegulatedCell Culturing at Interfaces 168 Regulation of Cell Fate by Nanostructured Surfaces172

3.3.3 Three-Dimensional Scaffolds for Tissue Engineering 175

3.3.4 Switchable Substrates and Matrices 176

References 181

4 Whole-Cell Sensor Structures 183

4.1 Case Studies 183

4.2 Basic Principles 184

4.3 Bioengineering 187

References 197

5 Biohybrid Silica-Based Materials 199

5.1 Case Studies 199

5.2 Basic Principles 205

5.2.1 Preparation of Silica-Based Xerogels 205

5.2.2 Biological Properties of Silica-Based Biocers 212

5.3 Bioengineering 215

5.3.1 Bioactive Sol–Gel Coatings and Composites 216

5.3.2 Biocatalytic Sol–Gel Coatings 221

5.3.3 Bioremediation 223

5.3.4 Cell-Based Bioreactors 228

5.3.5 Silica-Based Controlled Release Structures 229

5.3.6 Patterned Structures 230

5.4 Silicified Geological Biomaterials 231

References 234

6 Biomineralization 237

6.1 Case Studies 237

6.2 Basic Principles 240

6.2.1 Precipitation 244 Thermodynamics of Mineralization 245 Kinetics of Mineralization 250

6.2.2 Phenomenology of Biomineralization 253

6.2.3 Basic Mechanisms in Biomineralization 254

6.2.4 Biologically Mediated Mineralization: the Competitionbetween Inhibition and Growth 255 Effect of Polypeptides on Precipitate Habitus 256 The Formation of Metastable Polymorphs 258

6.2.5 Biologically Induced Mineralization: Role of theEpicellular Space and the Extracellular Polymeric Substances260

6.2.6 Biologically Controlled Mineralization: MolecularPreorganization, Recognition, and Vectorial Growth 267 Intracellular Mineralization 267 Epi- and Extracellular Mineralization 272

6.2.7 Mineralization of Diatom Shells: an Example of UnicellularHierarchical Structures 277

6.2.8 Mineralization of Bone: an Example of MulticellularBiomineralization 282 The Mesoscopic Architecture of Bone 284 Bone Remodeling and Bone Repair 287 The Nanoscopic Structure of the Extracelluar Matrix ofBone 292 The Polymer-Induced Liquid Precursor Process 298 Scale-Dependent Mechanical Behavior of Bone 301

6.2.9 Ancient Evidence of Biomineralization 304 Stromatolites: the Oldest Fossils by BiogenicMineralization 304

6.3 Bioengineering 306

6.3.1 Bacteria-Derived Materials Development 306 Bio-Palladium: Biologically Controlled Growth ofMetallic Nanoparticles 306 Biogenic Ion Exchange Materials 313

6.3.2 Bio-Inspired Design of Mineralized Collagen and Bone-LikeMaterials 314 Biomimetic Growth of Apatite–GelatinNanocomposites 314 Biomimetic Manufacturing of Mineralized CollagenScaffolds 324

6.3.3 Biomimicking of Bone Tissue 338 Natural versus Synthetic Biopolymers for Scaffold Design339 Protein-Engineered Synthetic Polymers 341 Protein-Engineered Collagen Matrices 345

6.3.4 Microbial Carbonate Precipitation in ConstructionMaterials 354

6.3.5 The Potential of Biomineralization for Carbon Capture andStorage (CCS) 357

References 359

7 Self-Assembly 367

7.1 Case Study 367

7.2 Basic Principles 372

7.2.1 Basic Phenomena of Self-Assembly and Self-Organization372

7.2.2 Self-Assembly of Protein Filaments: the Cytoskeleton373

7.2.3 Self-Assembly of b-Sheets: the Amyloid Fibrils 380

7.2.4 Self-Assembly of Two-Dimensional Protein Lattices: theBacterial Surface Layers (S-Layers) 381

7.2.5 Self-Organized Structures of Lipids 392

7.2.6 Liquid Crystals 396

7.3 Bioengineering 398

7.3.1 In Vitro Self-Assembly of Large-Scale NanostructuredBiomaterials 399

7.3.2 Template-Directed Assembly of Artificial Nanoparticles andNanowires 413

7.3.3 Template-Free Directed Self-Assembly of Nanoparticles429

References 437

Appendix A Constants, Units, and Magnitudes 441

A.1 Fundamental Constants 441

A.2 Table of SI Base Units 441

A.3 Table of Derived Units 442

A.4 Magnitudes 442

A.4.1 Sizes 442

A.4.2 Energies 443

A.4.3 Rates and Diffusion Constants 443

Appendix B Energy of a Bent Fiber 445

Appendix C Circular Dichroism Spectroscopy 447

Appendix D Task Solutions 449

Index 453

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  • Anonymous

    Posted April 6, 2014

    Katie to Levi

    Go to 'you only live once' res3. I'll be waiting. -Katie

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    Posted June 28, 2013

    Good book pls look

    This book is a good book and i like you youre name is ben

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