Bioactive Peptides

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Overview

Focuses on Biology, Pharmacology, and Therapeutic Applications

The study and diverse applications of bioactive peptides traverse many sub-disciplines within chemistry, biology, physics, and medicine. Answering a long-standing need, Bioactive Peptides focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. Moving peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics, it presents the overall contribution that peptide science has made to molecular, cellular, and whole organism biology, while also discussing future targets and therapeutic applications.

Beneficial for Experts and Novices Alike

Part I provides details of bioactive peptides that interact with common drug targets and analyzes some of the most competitive areas of current research worldwide. While it is widely known that mammalian physiological systems utilize bioactive peptides that have yet to be discovered, other animals provide a rich and valuable source of bioactive peptides. This fascinating area of science is the theme of Part II. Parts III and IV investigate the unique bioactivities of various peptides that are ripe for further exploration.

This definitive reference also includes:

  • A detailed description and analysis of a broad range of peptides that interact with G protein-coupled receptors, the quantitatively dominant drug target
  • A discussion of non-ribosomal peptides, which hold promise as sources of endogenous mediators
  • Important examples of common methodologies employed to identify, characterize, and further develop bioactive peptides from a range of natural sources

With mounting worldwide interest in their therapeutic potential, bioactive peptides—including the identification of new species, the synthesis of structural analogues, and diverse applications in biology and medicine—will likely remain at the forefront of scientific endeavor for many decades. Providing even casual readers with a broad flavor of the nature and applications of peptides, this volume attracts and excites tomorrow’s researchers who are charged with further developing and implementing the findings presented herein.

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Editorial Reviews

From the Publisher
The book will be useful for researchers in protein chemistry and biochemistry, molecular biologists and physicians, and teachers and students of medical schools and universities specialized in proteomics.
—G. Ya. Wiederschain, Doctor of Biological Sciences, in Biochemistry (Moscow)
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Product Details

  • ISBN-13: 9781420061147
  • Publisher: Taylor & Francis
  • Publication date: 5/8/2009
  • Pages: 503
  • Product dimensions: 7.20 (w) x 10.00 (h) x 1.10 (d)

Meet the Author

John Howl, Ph.D., is a professor of molecular pharmacology within the Research Institute in Healthcare Science, School of Applied Sciences, University of Wolverhampton, UK. He is a regular contributor to international conferences and co-author of numerous scientific articles describing the biological activities of novel peptides. Professor Howl is also a member of the European Peptide Society and founder of Pantechnia, a company that provides both de novo materials and consultancy in the synthesis and applications of bioactive peptides.

Sarah Jones, Ph.D., is a research fellow within the Research Institute in Healthcare Sciences and has worked alongside Professor Howl for many years. Besides her role as a product specialist to Pantechnia, her current research endeavors include the application of cell penetrating peptides to modulate biological phenomena, with a particular emphasis on novel inducers of apoptosis. Dr. Jones has produced numerous scientific publications within the field of bioactive peptides, is a regular contributor at international meetings, and is a member of the European Peptide Society.

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Table of Contents

RECEPTOR LIGANDS

Angiotensins: From Endocrine to Intracrine Functions, M.C. Chappell

CT, CGRP, Amylin, and Adrenomedullins, D.L. Hay and D.R. Poyner

Neuropeptide Y Family Peptides, C. Cavadas, J. Rosmaninho Salgado, and E. Grouzmann

Pituitary Adenylate Cyclase-Activating Polypeptide, E.M. Lutz, C. Pou, T.K. Monaghan, and C. MacKenzie

Opioid Peptides, J.V. Aldrich

Cholecystokinins and Gastrins, J.F. Rehfeld

The Chemistry and Biology of Insulin-Like Peptide 3, a Novel Member of the Insulin Superfamily, F. Shabanpoor, R.A. Hughes, F. Separovic, and J.D. Wade

Somatostatin Analogs, K. Öberg

Tachykinins, N.M. Page, P. Subramaniam, and S.E. Newton

Neurotensin, P.R. Dobner and R.E. Carraway

Twenty-Five Years of Galanin Research, J. Runesson, J.K. Robinson, U. Eriksson Sollenberg, and Ü. Langel

Bioactive Peptides in Gut–Brain Signaling, E. Näslund, P. Grybäck, and P.M. Hellström

NONRIBOSOMAL PEPTIDES

Nonribosomal Peptides, A.A. Roberts, L.A. Pearson, and B.A. Neilan

HOST-DEFENSE PEPTIDES AND ANTIMICROBIALS

Anuran Host-Defense Peptides That Complex with Ca2+ Calmodulin and Inhibit the Synthesis of the Cell Signaling Agent Nitric Oxide by Neuronal Nitric Oxide Synthase, J.R. Doyle, J.H. Bowie, R.J. Jackway, L.E. Llewellyn, T.L. Pukala, M.A. Apponyi, and G.W. Booker

Host-Defense Peptides from the Secretion of the Skin Glands of Frogs and Toads: Membrane-Active Peptides from the Genera Litoria, Uperoleia, and Crinia, J.H. Bowie, R.J. Jackway, F. Separovic, J.A. Carver, and M. J. Tyler

Antimicrobial Peptides, A.M. McDermott

VENOM COMPONENTS AND TOXINS

Mast Cell Degranulating Peptides, J.A. Price

Mastoparans, S. Jones and J. Howl

Spider Venom and Hemolymph-Derived Cytolytic and Antimicrobial Peptides, L. Kuhn-Nentwig, C. Trachsel, and W. Nentwig

Index

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