Bioactive Peptides / Edition 1

by John Howl, Sarah Jones

Overview

Focuses on Biology, Pharmacology, and Therapeutic Applications

The study and diverse applications of bioactive peptides traverse many sub-disciplines within chemistry, biology, physics, and medicine. Answering a long-standing need, Bioactive Peptides focuses on the biology, pharmacology, and therapeutic applications of endogenous peptide mediators and their analogues. Moving peptide science beyond chemical synthesis strategies and into the realms of peptide biology and therapeutics, it presents the overall contribution that peptide science has made to molecular, cellular, and whole organism biology, while also discussing future targets and therapeutic applications.

Beneficial for Experts and Novices Alike

Part I provides details of bioactive peptides that interact with common drug targets and analyzes some of the most competitive areas of current research worldwide. While it is widely known that mammalian physiological systems utilize bioactive peptides that have yet to be discovered, other animals provide a rich and valuable source of bioactive peptides. This fascinating area of science is the theme of Part II. Parts III and IV investigate the unique bioactivities of various peptides that are ripe for further exploration.

This definitive reference also includes:

• A detailed description and analysis of a broad range of peptides that interact with G protein-coupled receptors, the quantitatively dominant drug target



• A discussion of non-ribosomal peptides, which hold promise as sources of endogenous mediators



• Important examples of common methodologies employed to identify, characterize, and further develop bioactive peptides from a range of natural sources

With mounting worldwide interest in their therapeutic potential, bioactive peptides—includ

Product Details

ISBN-13:	9780367385736
Publisher:	Taylor & Francis
Publication date:	10/21/2019
Pages:	504
Product dimensions:	7.00(w) x 10.00(h) x (d)

Table of Contents

Preface ix

Editors xi

Contributors xiii

Part I Receptor Ligands

Chapter 1 Angiotensins: From Endocrine to Intracrine Functions Mark C. Chappell 3

Chapter 2 CT, CGRP, Amylin, and Adrenomedullins Debbie L. Hay David R. Poyner 21

Chapter 3 Neuropeptide Y Family Peptides Cláudia Cavadas Joana Rosmaninho Salgado Eric Grouzmann 43

Chapter 4 Pituitary Adenylate Cyclase-Activating Polypeptide Eve M. Lutz Chantevy Pou Thomas K. Monaghan Christopher MacKenzie 67

Chapter 5 Opioid Peptides Jane V. Aldrich 103

Chapter 6 Cholecystokinins and Gastrins Jens F. Rehfeld 137

Chapter 7 The Chemistry and Biology of Insulin-Like Peptide 3, a Novel Member of the Insulin Superfamily Fazel Shabanpoor Richard A. Hughes Frances Separovic John D. Wade 159

Chapter 8 Somatostatin Analogs Kjell Öberg 169

Chapter 9 Tachykinins Nigel M. Page Parvathy Subramaniam Suzanne E. Newton 189

Chapter 10 Neurotensin Paul R. Dobner Robert E. Carraway 211

Chapter 11 Twenty-Five Years of Galanin Research Johan Runesson John K. Robinson Ulla Eriksson Sollenberg Ülo Langel 237

Chapter 12 Bioactive Peptides in Gut-Brain Signaling Erik Näslund Per Grybäck Per M. Hellström 261

Part II Nonribosomal Peptides

Chapter 13 Nonribosomal Peptides Alexandra A. Roberts Leanne A. Pearson Brett A. Neilan 277

Part III Host-Defense Peptides and Antimicrobials

Chapter 14 Anuran Host-Defense Peptides That Complex with Ca²⁺ Calmodulin and Inhibit the Synthesis of the Cell Signaling Agent Nitric Oxide by Neuronal Nitric Oxide Synthase Jason R. Doyle John H. Bowie Rebecca J. Jackway Lyndon E. Llewellyn Tara L. Pukala Margit A. Apponyi Grant W. Booker 315

Chapter 15 Host-Defense Peptides from the Secretion of the Skin Glands of Frogs and Toads: Membrane-Active Peptides from the Genera Litoria, Uperoleia, and Crinia John H. Bowie Rebecca J. Jackway Frances Separovic John A. Carver Michael J. Tyler 333

Chapter 16 Antimicrobial Peptides Alison M. McDermott 357

Part IV Venom Components and Toxins

Chapter 17 Mast Cell Degranulating Peptides Joseph A. Price 405

Chapter 18 Mastoparans Sarah Jones John Howl 429

Chapter 19 Spider Venom and Hemolymph-Derived Cytolytic and Antimicrobial Peptides Lucia Kuhn-Nentwig Christian Trachsel Wolfgang Nentwig 447

Index 465