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The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.
“This book is well organised, containing most key subjects one would expect in the multiple research areas of biocatalysis. It is suitable for graduate level students, postdocs, and industrial researchers. It also can be regarded as an auxiliary textbook for students who wish to know the pros and cons of biocatalysis in chemical processes, and what the future holds for the development of biotechnology in green chemistry.” (Chemistry World, 2012)
Preface xi
Part I. Introduction Chapters 1
1. Biotechnology Tools for Green Synthesis: Enzymes, Metabolic Pathways, and Their Improvement by Engineering 3
2. How Green Can the Industry Become with Biotechnology? 23
3. Emerging Enzymes and Their Synthetic Applications 45
4. Reaction Efficiencies and Green Chemistry Metrics of Biotransformations 67
Part II. Application and Case Studies-Pharmaceuticals and Fine Chemicals 89
5. Biocatalytic Routes to Chiral Intermediates for Development of Drugs 91
6. Transglutaminase for Protein Drug Modification: Pegylation and Beyond 151
7. Microbial Production of Plant-Derived Pharmaceutical Natural Products Through Metabolic Engineering: Artemisinin and Beyond 173
8. Toward Greener Therapeutic Proteins 197
Part III. Application and Case Studies-Flavor & Fragrance, Agrochemicals and Fine Chemicals 221
9. Opportunities for Biocatalysis in the Flavor, Fragrance, and Cosmetic Industry 223
10. Application of Biocatalysis in the Agrochemical Industry 255
11. Green Porduction of Fine Chemicals by Isolated Enzymes 277
12. Whole Cell Production of Fine Chemicals and Intermediates 299
Part IV. Application and Case Studies-Polymers and Renewable Chemicals 327
13. Green Chemistry for the Production of Biodegradable, Biorenewable, Biocompatible, and Polymers 329
14. Enzymatic Degradation of Lignocellulosic Biomass 361
15. Bioconversion of Nenewables-Plant Oils 391
16. Microbial Bioprocesses for industrial-Scale Chemical Production 429
Index 469
Overview