Biocatalysts in the Pharmaceutical and Biotechnology Industries

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Biocatalysis in the Pharmaceutical and Biotechnology Industries presents different classes of enzymes in catalysis of chemical reactions to generate chiral molecules and fine chemicals useful in chemo-enzymatic synthesis of pharmaceuticals and agrochemicals. This book explores developments in the biotechnology of enzymes. It covers the use of oxido-reductases, amine oxidases, and aminotransferases in the synthesis of chiral alcohols, aminoalcohols, amino acids, and amines. It discusses aldolases and decarboxylases in asymmetric synthesis and describes techniques in enzyme immobilization, approaches to screen for biocatalysts, and directed evolution of biocatalysts for improving enantioselectivity and substrate specificity.

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Product Details

  • ISBN-13: 9780849337321
  • Publisher: Taylor & Francis
  • Publication date: 9/28/2006
  • Pages: 893
  • Product dimensions: 10.30 (w) x 7.20 (h) x 2.00 (d)

Table of Contents

Nitrilases and Nitrile Hydratases; R. DiCosimo
Biocatalytic Deracemization: Dynamic Resolution, Stereoinversion, Enantioconvergent Processes and Cyclic Deracemization; Y.Simeó, W. Kroutil, and K. Faber
A Decade of Biocatalysis at Glaxo Wellcome; M. Mahmoudian
Biocatalysis for Synthesis of Chiral Pharmaceutical Intermediates; R.N. Patel
Directed Evolution of Lipases and Esterases for Organic Synthesis; A. Hidalgo and U.T. Bornscheuer
Flavin-Containing Oxidative Biocatalysts; M.W. Fraaije and W.J.H. van Berkel
Preparation of Chiral Pharmaceuticals through Enzymatic Acylation of Alcohols Amines; V. Gotor-Fernández, F. Rebollledo, and V. Gotor
Dynamic Kinetic Resolution and Asymmetric Transformations by Enzyme–Metal Combinations; M.J. Kim, Y. Ahn, and J. Park
Biotransformation of Natural or Synthetic Compounds for the Generation of Molecular Diversity; R. Azerad
Applications of Aromatic Hydrocarbon Dioxygenases; R.E. Parales and S.M. Resnick
A Genomic Approach to Investigating Baker’s Yeast Reductions; J.D. Stewart
Immobilization of Enzymes as Cross-linked Enzyme Aggregates: A Simple Method for Improving Performance; R.A. Sheldon
Biotechnological Applications of Aldolases; W.D. Fessner and S.Jennewein
Enzymatic Synthesis of Modified Nucleosides; L.A. Condezo, J. Fernández-Lucas, C.A. García-Burgos, A.R. Alcántara, and J.V. Sinisterra
Biocatalytic Reduction of Carboxylic Acids: Mechanism and Applications; P. Venkitasubramanian, L. Daniels, and J.P.N. Rosazza
Dehalogenases in Biodegradation and Biocatalysis; D.B. Janssen
Enzymatic Synthesis of Sugar Esters and Oligosaccharides from Renewable Resources; A. Ballesteros, F.J. Plou, M. Alcalde, M. Ferrer, H. García-Arellano, D. Reyes-Duarte, and I. Ghazi
Efficient Methods and Instrumentation for Engineering Custom Enzymes; S.J. Robles, W.J. Coleman, and M.M. Yang
Deaminating Enzymes of the Purine Cycle as Biocatalysts for Chemoenzymatic Synthesis and Transformation of Antiviral Agents Structurally Related to Purine Nucleosides; E. Santaniello, P. Ciuffreda, and L. Alessandrini
Microbial and Enzymatic Processes for the Production of Chiral Compounds; K. Honda, T. Ishige, and S. Shimizu
Discovery of Arylmalonate Decarboxylase and Conversion of the Function by Rational Design; K. Miyamoto and H. Ohta
Chemoenzymatic Preparation of Enantiopure Building Blocks of Synthetic Utility; K. Mori
Stereoselective Modifications of Polyhydroxylated Steroids; E. Fossati and S. Riva
Recent Developments in Enzymatic Acyloin Condensations; O. Ward and A. Singh
Synthesis of Chiral Alcohols with Carbonyl Reductase Library and Robust NAD(P)H Regenerating System; H. Yamamoto and A. Matsuyama
Comparative Analysis of Chemical and Biocatalytic Syntheses of Drug Intermediates; M.J. Homann, W.C. Suen, N. Zhang, and A. Zaks
Industrial Processes Using Lyases for C–C, C–N, and C–O Bond Formation; M. Pohl and A. Liese
State of the Art and Applications in Stereoselective Synthesis of Chiral Cyanohydrins; F. Effenberger, S. Förster, and C. Kobler
Chiral Switches: Problems, Strategies, Opportunities, and Experiences; R. Csuk
Enzyme Evolution for Chemical Process Applications; G.W. Huisman and J.J. Lalonde
Biocatalytic Routes to Nonracemic Chiral Amines; N.J. Turner and R. Carr
Enantioselective Biocatalytic Reduction of Ketones for the Synthesis of Optically Active Alcohols; S. Buchholz and H. Gröger
Enzyme Catalysis in Nonaqueous Media: Past, Present, and Future;
S. Dreyer, J. Lembrecht, J. Schumacher, and U. Kragl
Biocatalytic Concepts for the Synthesis of Optically Active Amines; S. Buchholz and H. Gröger

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