Biochemical Engineering: A Textbook for Engineers, Chemists and Biologists / Edition 1

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Completely revised, updated, and enlarged, this second edition now contains a subchapter on biorecognition assays, plus a chapter on bioprocess control added by the new co-author Jun-ichi Horiuchi, who is one of the leading experts in the field.
The central theme of the textbook remains the application of chemical engineering principles to biological processes in general, demonstrating how a chemical engineer would address and solve problems. To create a logical and clear structure, the book is divided into three parts. The first deals with the basic concepts and principles of chemical engineering and can be read by those students with no prior knowledge of chemical engineering. The second part focuses on process aspects, such as heat and mass transfer, bioreactors, and separation methods. Finally, the third section describes practical aspects, including medical device production, downstream operations, and fermenter engineering. More than 40 exemplary solved exercises facilitate understanding of the complex engineering background, while self-study is supported by the inclusion of over 80 exercises at the end of each chapter, which are supplemented by the corresponding solutions.
An excellent, comprehensive introduction to the principles of biochemical engineering.

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Product Details

  • ISBN-13: 9783527325368
  • Publisher: Wiley
  • Publication date: 12/14/2009
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 282
  • Product dimensions: 6.70 (w) x 9.40 (h) x 0.60 (d)

Meet the Author

Prof. Shigeo Katoh is now Professor emeritus at Kobe University, Japan. He was - after his retirement - a full professor at Hanyang University at Korea and a visiting professor at Cheng Kung University at Taiwan. Before his retirement, he was Head of the Bioengineering Laboratory at Kobe University, Japan. He holds a PhD in Chemical Engineering from the University of Kyoto, Japan. Prof. Katoh is an enthusiastic lecturer in Biochemical Engineering, Bioseparation Engineering and Immunotechnology. He is an outstanding expert in biochemical engineering and has published numerous papers in this field.

Prof. Jun-ichi Horiuchi is Director of the Instrumental Analysis Center at the Kitami Institute of Technology (Japan) since 2010. He obtained his Master degree in Engineering from Hokkaido University and thereafter went to the Science University of Tokyo, where he received his PhD in biotechnology in 1995. Afterwards he spent several years as research engineer at Toyo Engineering Corporation, before he became Professor at the Kitami Institute of Technology in 1998. Prof. Horiuchis research interests are in the field of bioprocess control and optimization and up to now he published over 60 peer reviewed jounal contributions, 12 patents and 9 book contributions.

Prof. em. Fumitake Yoshida was one of the world's most respected chemical engineers. Most recently he was professor emeritus of chemical engineering at Kyoto University and well beyond his retirement he continued to be a visiting lecturer at universities around the world. He conducted research on various mass transfer operations, gas-liquid systems in particular, investigating their applications in bioengineering and medical technology. Yoshida received his BS and PhD degrees in engineering from Kyoto University. Among his many awards and citations was election to the National Academy of Engineering of the United States in 1979 for his leadership in chemical, biochemical, and biomedical engineering in Japan.

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Table of Contents


PART I: Basic Concepts and Principles

Background and Scope
Dimensions and Units
Intensive and Extensive Properties
Equilibria and Rates
Batch vs. Continuous Operation
Material Balance
Energy Balance

Heat Conduction and Molecular Diffusion
Fluid Flow and Momentum Transfer
Laminar vs. Turbulent Flow
Transfer Phenomena in Turbulent Flow
Film Coefficients of Heat and Mass Transfer

Fundamental Reaction Kinetics

Cell Growth
Growth Phases in Batch Culture
Factors Affecting Rates of Cell Growth
Cell Growth in Batch Fermentors and Continuous Stirred Tank Fermentor (CSTF)

PART II: Unit Operations and Apparatus for Bio-Systems

Overall Coefficients U and Film Coefficients h
Mean Temperature Difference
Estimation of Film Coefficients h
Estimation of Overall Coefficients U

Overall Coefficients K and Film Coefficients k of Mass Transfer
Types of Mass Transfer Equipment
Models for Mass Transfer at the Interface
Liquid Phase Mass Transfer with Chemical Reactions
Correlations for Film Coefficients of Mass Transfer
Performance of Packed Column

Some Fundamental Concepts
Bubbling Gas-Liquid Reactors
Mechanically Stirred Tanks
Gas Dispersion in Stirred Tanks
Bubble Columns
Airlift Reactors
Packed-Bed Reactors

Reverse Osmosis
Membrane Modules

Conventional Filtration
Cell Disruption

Kinetics of Thermal Death of Cells
Batch Heat Sterilization of Culture Media
Continuous Heat Sterilization of Culture Media
Sterilizing Filtration

Equilibria in Adsorption
Rates of Adsorption into Adsorbent Particles
Single- and Multi-Stage Processes for Adsorption
Adsorption in Fixed Beds
Separation by Chromatography
Biorecognition Assay

PART III: Practical Aspects in Bioengineering

Stirrer Power Requirements for Non-Newtonian Liquids
Heat Transfer in Fermentors
Gas-Liquid Mass Transfer in Fermentors
Criteria for Scaling-Up Fermentors
Modes of Fermentor Operation
Fermentors for Animal Cell Culture

Instrumentation of Bioprocesses
Control of Bioprocesses
Advanced Control of Bioprocesses

Separation of Microorganisms by Filtration and Microfiltration
Separation by Chromatography
Separation in Fixed Beds
Sanitation in Downstream Processes

Blood and Its Circulation
Oxygenation of Blood
Artificial Kidney
Bioartificial Liver


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