Biochemistry and Molecular Biology of Antimicrobial Drug Action / Edition 6
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Biochemistry and Molecular Biology of Antimicrobial Drug Action / Edition 6

by Trevor J. Franklin, George Alan Snow
     
 

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ISBN-10: 0387225544

ISBN-13: 9780387225548

Pub. Date: 03/28/2005

Publisher: Springer US

The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.

Overview

The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.

Product Details

ISBN-13:
9780387225548
Publisher:
Springer US
Publication date:
03/28/2005
Edition description:
6th ed. 2005
Pages:
182
Product dimensions:
7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

Prefaceix
Preface to the fifth editionxi
1The Development of Antimicrobial Agents Past, Present and Future1
1.1The social and economic importance of antimicrobial agents1
1.2An outline of the historical development of antimicrobial agents2
1.3Reasons for studying the biochemistry and molecular biology of antimicrobial compounds9
1.4Uncovering the molecular basis of antimicrobial action10
1.5Scope and layout of the present book13
2Vulnerable Shields - the Cell Walls of Bacteria and Fungi15
2.1Functions of the cell wall15
2.2Structure of the bacterial wall15
2.3Structure and biosynthesis of peptidoglycan19
2.4Antibiotics that inhibit peptidoglycan biosynthesis26
2.5Drugs that interfere with the biosynthesis of the cell wall of mycobacteria37
2.6The structure of the fungal cell wall38
2.7Inhibitors of the biosynthesis of the fungal cell wall39
3Antiseptics, Antibiotics and the Cell Membrane43
3.1Microbe killers: antiseptics and disinfectants43
3.2Polypeptide antibiotics46
3.3Ionophoric antibiotics49
3.4Antifungal agents that interfere with the function and biosynthesis of membrane sterols55
4Inhibitors of Nucleic Acid Synthesis61
4.1Compounds affecting the biosynthesis and utilization of nucleotide precursors62
4.2Inhibitors of nucleic acid biosynthesis at the polymerization stage66
5Inhibitors of Protein Biosynthesis77
5.1Ribosomes77
5.2Stages in protein biosynthesis78
5.3Puromycin81
5.4Inhibitors of aminoacyl-tRNA formation82
5.5Inhibitors of initiation and translation83
5.6Inhibitors of peptide bond formation and translocation89
5.7Nitrofurantoin - a ribosomal poison?95
5.8Effects of inhibitors of 70S ribosomes on eukaryotic cells95
6Antimicrobial Drugs with other Modes of Action97
6.1Antibacterial agents97
6.2A unique antifungal antibiotic - griseofulvin98
6.3Antiviral agents98
6.4Antiprotozoal agents101
7Penetrating the Defences: How Antimicrobial Drugs Reach Their Targets107
7.1Cellular permeability barriers to drug penetration107
7.2Multidrug efflux in bacteria111
7.3Examples of the uptake of antibacterial drugs113
7.4Uptake of antimicrobial drugs by eukaryotic pathogens117
8The Genetic Basis of Resistance to Antimicrobial Drugs119
8.1Mutations and the origins of drug-resistance genes120
8.2Gene mobility and transfer in bacterial drug resistance123
8.3Global regulators of drug resistance in Gram-negative bacteria131
9Biochemical Mechanisms of Resistance to Antimicrobial Drugs133
9.1Enzymic inactivation of drugs133
9.2Modification of drug targets145
9.3Drug efflux pumps151
9.4Other mechanisms of resistance154
9.5Drug resistance and the future of chemotherapy155
Index159

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