Biochemistry and Physiology of the Neutrophil

Biochemistry and Physiology of the Neutrophil

by Steven W. Edwards
     
 

This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of this cell, highlighting the mechanisms by which they seek out and destroy pathogenic microorganisms. The development of these cells during haematopoiesis is described and the mechanisms that lead to the production of… See more details below

Overview

This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of this cell, highlighting the mechanisms by which they seek out and destroy pathogenic microorganisms. The development of these cells during haematopoiesis is described and the mechanisms that lead to the production of reactive oxidants and the intracellular signal transduction systems that lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally, there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.

Product Details

ISBN-13:
9780521018500
Publisher:
Cambridge University Press
Publication date:
07/31/2005
Edition description:
New Edition
Pages:
320
Product dimensions:
5.98(w) x 8.98(h) x 0.67(d)

Table of Contents

Abbreviations
Preface
1Neutrophils and host defence: The fight against infection1
2The development and structure of mature neutrophils33
3The generation and recognition of neutrophil-activating factors: Structure and function of neutrophil receptors77
4The cytoskeleton: The molecular framework regulating cell shape and the traffic of intracellular components128
5The respiratory burst: The generation of reactive oxygen metabolites and their role in microbial killing149
6Neutrophil activation: The production of intracellular signalling molecules188
7Neutrophil priming: Regulation of neutrophil function during inflammatory activation235
8Disorders of neutrophil function263
Index291

Read More

Customer Reviews

Average Review:

Write a Review

and post it to your social network

     

Most Helpful Customer Reviews

See all customer reviews >