Biochemistry and Physiology of the Neutrophil / Edition 1

Biochemistry and Physiology of the Neutrophil / Edition 1

by Steven W. Edwards
     
 

ISBN-10: 0521416981

ISBN-13: 9780521416986

Pub. Date: 03/28/1994

Publisher: Cambridge University Press

This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of this cell, highlighting the mechanisms by which they seek out and destroy pathogenic microorganisms. The development of these cells during haematopoiesis is described and the mechanisms that lead to the production of…  See more details below

Overview

This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of this cell, highlighting the mechanisms by which they seek out and destroy pathogenic microorganisms. The development of these cells during haematopoiesis is described and the mechanisms that lead to the production of reactive oxidants and the intracellular signal transduction systems that lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally, there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.

Product Details

ISBN-13:
9780521416986
Publisher:
Cambridge University Press
Publication date:
03/28/1994
Edition description:
New Edition
Pages:
299
Product dimensions:
5.98(w) x 8.98(h) x 0.87(d)

Table of Contents

1. Neutrophils and host defence: the fight against infection; 2. The development and structure of neutrophils; 3. The generation and recognition of neutrophil-activating factors: structure and function of neutrophil receptors; 4. The cytoskeleton: the molecular framework regulating cell shape and the traffic of intracellular components; 5. The respiratory burst: the generation of reactive oxygen metabolites and their role in microbial killing; 6. Neutrophil activation: the production of intracellular signalling molecules; 7. Neutrophil priming: regulation of neutrophil function during inflammatory activation; 8. Disorders of neutrophil function; Index.

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