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This book describes the role of the neutrophil in infection and inflammation and provides an up-to-date review of the biochemistry and physiology of this cell, highlighting the mechanisms by which they seek out and destroy pathogenic microorganisms. The development of these cells during haematopoiesis is described and the mechanisms that lead to the production of reactive oxidants and the intracellular signal transduction systems that lead to the cell's activation are reviewed. The book also discusses recent discoveries concerning the role of cytokines in the regulation of neutrophil function together with the importance of the neutrophil as a generator of inflammatory cytokines. Finally, there is a description of the biochemical defects that give rise to some of the neutrophil-associated human diseases.
The book contains black-and-white illustrations.
1. Neutrophils and host defence: the fight against infection; 2. The development and structure of neutrophils; 3. The generation and recognition of neutrophil-activating factors: structure and function of neutrophil receptors; 4. The cytoskeleton: the molecular framework regulating cell shape and the traffic of intracellular components; 5. The respiratory burst: the generation of reactive oxygen metabolites and their role in microbial killing; 6. Neutrophil activation: the production of intracellular signalling molecules; 7. Neutrophil priming: regulation of neutrophil function during inflammatory activation; 8. Disorders of neutrophil function; Index.