Biochemistry / Edition 4

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1995 Hard cover 4th ed. New. No dust jacket as issued. Sewn binding. Paper over boards. 1064 p. Audience: General/trade. *****PLEASE NOTE: This item is shipping from an ... authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

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Overview

This book is an outgrowth of my teaching of biochemistry to undergraduates, graduate students, and medical students at Yale and Stanford. My aim is to provide an introduction to the principles of biochemistry that gives the reader a command of its concepts and language. I also seek to give an appreciation of the process of discovery in biochemistry.

This book provides a comprehensive introduction to the principles of biochemistry, giving the reader a command of biochemistry's basic concepts of language.

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Product Details

  • ISBN-13: 9780716720096
  • Publisher: Freeman, W. H. & Company
  • Publication date: 3/28/1995
  • Edition description: 4th Edition
  • Edition number: 4
  • Pages: 1064
  • Product dimensions: 8.83 (w) x 11.35 (h) x 1.77 (d)

Read an Excerpt

Space, time, and energy are discussed from a biochemical perspective. (pages 5-6)

1. Space:
To help yourself visualize relative scale, note the size of a molecule you are studying and compare it with others. For example, glucose, one of the most commonly discussed carbohydrate molecules in metabolism, has a length of about 8 angstroms. Compare it with the blood protein molecule hemoglobin, about 65 angstroms across at its widest diameter.

Stryer uses the angstrom (Å) as a unit of dimension for structures less than 100 angstroms in size, and the units nm (nanometer) or mm (micrometer) for longer dimensions.

2. Time:
Times required for reactions at the atomic or even the molecular level are extremely short, ranging from a few picoseconds (10-12 s) to milliseconds (10-3 s) for many enzymatic reactions. The set of biochemical reactions required for the duplication of a bacterial cell takes much longer¾from 15 to 20 minutes, under optimum nutritional conditions¾but nevertheless is rapid compared with many other everyday phenomena.

3. Energy:
Energy changes in biochemical systems range from less than one kilocalorie per mole (kcal/mol), for thermal motion, to several hundred kcal/mol, for the complete oxidation of glucose.

Biochemical reactions that involve the formation or breakage of strong, covalent bonds typically require an energy input as high as 80 kcal/mol.

Three types of weak attractive forces are essential to biological structures and processes. (pages 7-9)

4. Electrostatic bonds:
(such as ionic interactions), or salt bridges. Note on page 7 how the strength of these bonds is strongly dependent on the dielectric constant of the medium. (Energies range from 3 to 7 kcal/mol.) Bonding between two oppositely charged ions in a protein is stronger if the pair is buried in the interior of the molecule, from which water is excluded.

5. Hydrogen bonds: These bonds can involve either uncharged or charged molecules. The sharing of a hydrogen atom by two other atoms is strongest when the three atoms lie in a straight line. (Energies range from 3 to 7 kcal/mol.)

Stryer cites the a helix of proteins and DNA base pairing as good examples of hydrogen bonding. Other examples are interactions among proteins and nucleotides, as occurs in transcription and translation, and interactions between macromolecules and water (or other small polar molecules).

6. Van der Waals interactions:
These are the weakest of the three types of noncovalent forces. Van der Waals attractions between adjacent atoms are due to temporary asymmetries in the distribution of their electrons, and to steric complementarities within a group of atoms. (Energy of about 1 kcal/mol.)

Water is intimately involved in all aspects of biochemistry and molecular biology. (pages 9-10)

7. Properties of water:
Stryer also summarizes the unique properties that make water biologically important. Water molecules are polar and hence are readily able to form hydrogen bonds among themselves. The same properties also allow water to compete for ionic and hydrogen bonds between polar molecules, making it an excellent solvent for polar substances.

Nonaqueous environments are also important in biochemical structure and function. (page 11)

8. Hydrophobic interactions:
Chapter 1 closes with a discussion of hydrophobic interactions among biological molecules. Nonpolar groups surrounded by water associate with each other, not only because they have an affinity for each other, but primarily because water molecules have a greater tendency to form hydrogen bonds with each other than with nonpolar molecules. This phenomenon is important in the formation of membrane lipid bilayers. It also plays a role in the folding of protein chains to form globular structures whose interiors are virtually free of water (see figure 2-44).

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Table of Contents

Topics.....x
Preface to the Fourth Edition.....xxvii
Prefaces to Prior Editions.....xxx
Part I: Molecular Design of Life.....1
Part II: Proteins: Conformation, Dynamics, and Function.....145
Part III: Metabolic Energy: Generation and Storage.....441
Part IV: Miosynthesis of Building Blocks.....683
Part V: Genes: Replication and Expression.....785
Appendixes.....1012
Answers to Problems.....1016
Index.....1035
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  • Anonymous

    Posted December 11, 2000

    Stryer Biochemistry for Veterinary students

    I would thoroughly recommend 'Biochemistry' by Stryer to any Veterinary student undertaking a biochemistry course as part of their vet course. It explains all of the crucial biochemical processes and pathways relevant to vet science concisely and clearly, and is very useful when writing essays.

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