Biochemistry / Edition 4

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $1.99
Usually ships in 1-2 business days
(Save 98%)
Other sellers (Hardcover)
  • All (71) from $1.99   
  • New (3) from $58.96   
  • Used (68) from $1.99   
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any coupons and promotions
Seller since 2015

Feedback rating:



New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

1995 Hard cover 4th ed. New. No dust jacket as issued. Sewn binding. Paper over boards. 1064 p. Audience: General/trade. *****PLEASE NOTE: This item is shipping from an ... authorized seller in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

Ships from: Thessaloniki, Greece

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
Seller since 2015

Feedback rating:


Condition: New
Brand new.

Ships from: acton, MA

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
Seller since 2015

Feedback rating:


Condition: New
Brand new.

Ships from: acton, MA

Usually ships in 1-2 business days

  • Standard, 48 States
  • Standard (AK, HI)
Page 1 of 1
Showing All
Sort by


This book is an outgrowth of my teaching of biochemistry to undergraduates, graduate students, and medical students at Yale and Stanford. My aim is to provide an introduction to the principles of biochemistry that gives the reader a command of its concepts and language. I also seek to give an appreciation of the process of discovery in biochemistry.

This book provides a comprehensive introduction to the principles of biochemistry, giving the reader a command of biochemistry's basic concepts of language.

Read More Show Less

Product Details

  • ISBN-13: 9780716720096
  • Publisher: Freeman, W. H. & Company
  • Publication date: 3/28/1995
  • Edition description: 4th Edition
  • Edition number: 4
  • Pages: 1064
  • Product dimensions: 8.83 (w) x 11.35 (h) x 1.77 (d)

Read an Excerpt

Space, time, and energy are discussed from a biochemical perspective. (pages 5-6)

1. Space:
To help yourself visualize relative scale, note the size of a molecule you are studying and compare it with others. For example, glucose, one of the most commonly discussed carbohydrate molecules in metabolism, has a length of about 8 angstroms. Compare it with the blood protein molecule hemoglobin, about 65 angstroms across at its widest diameter.

Stryer uses the angstrom (Å) as a unit of dimension for structures less than 100 angstroms in size, and the units nm (nanometer) or mm (micrometer) for longer dimensions.

2. Time:
Times required for reactions at the atomic or even the molecular level are extremely short, ranging from a few picoseconds (10-12 s) to milliseconds (10-3 s) for many enzymatic reactions. The set of biochemical reactions required for the duplication of a bacterial cell takes much longer¾from 15 to 20 minutes, under optimum nutritional conditions¾but nevertheless is rapid compared with many other everyday phenomena.

3. Energy:
Energy changes in biochemical systems range from less than one kilocalorie per mole (kcal/mol), for thermal motion, to several hundred kcal/mol, for the complete oxidation of glucose.

Biochemical reactions that involve the formation or breakage of strong, covalent bonds typically require an energy input as high as 80 kcal/mol.

Three types of weak attractive forces are essential to biological structures and processes. (pages 7-9)

4. Electrostatic bonds:
(such as ionic interactions), or salt bridges. Note on page 7 how the strength of these bonds is strongly dependent on the dielectric constant of the medium. (Energies range from 3 to 7 kcal/mol.) Bonding between two oppositely charged ions in a protein is stronger if the pair is buried in the interior of the molecule, from which water is excluded.

5. Hydrogen bonds: These bonds can involve either uncharged or charged molecules. The sharing of a hydrogen atom by two other atoms is strongest when the three atoms lie in a straight line. (Energies range from 3 to 7 kcal/mol.)

Stryer cites the a helix of proteins and DNA base pairing as good examples of hydrogen bonding. Other examples are interactions among proteins and nucleotides, as occurs in transcription and translation, and interactions between macromolecules and water (or other small polar molecules).

6. Van der Waals interactions:
These are the weakest of the three types of noncovalent forces. Van der Waals attractions between adjacent atoms are due to temporary asymmetries in the distribution of their electrons, and to steric complementarities within a group of atoms. (Energy of about 1 kcal/mol.)

Water is intimately involved in all aspects of biochemistry and molecular biology. (pages 9-10)

7. Properties of water:
Stryer also summarizes the unique properties that make water biologically important. Water molecules are polar and hence are readily able to form hydrogen bonds among themselves. The same properties also allow water to compete for ionic and hydrogen bonds between polar molecules, making it an excellent solvent for polar substances.

Nonaqueous environments are also important in biochemical structure and function. (page 11)

8. Hydrophobic interactions:
Chapter 1 closes with a discussion of hydrophobic interactions among biological molecules. Nonpolar groups surrounded by water associate with each other, not only because they have an affinity for each other, but primarily because water molecules have a greater tendency to form hydrogen bonds with each other than with nonpolar molecules. This phenomenon is important in the formation of membrane lipid bilayers. It also plays a role in the folding of protein chains to form globular structures whose interiors are virtually free of water (see figure 2-44).

Read More Show Less

Table of Contents

Preface to the Fourth Edition.....xxvii
Prefaces to Prior
Part I: Molecular Design of Life.....1
Part II: Proteins: Conformation, Dynamics, and Function.....145
Part III: Metabolic Energy: Generation and Storage.....441
Part IV: Miosynthesis of Building Blocks.....683
Part V: Genes: Replication and Expression.....785
Answers to Problems.....1016
Read More Show Less

Customer Reviews

Average Rating 4
( 1 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously
Sort by: Showing 1 Customer Reviews
  • Anonymous

    Posted December 11, 2000

    Stryer Biochemistry for Veterinary students

    I would thoroughly recommend 'Biochemistry' by Stryer to any Veterinary student undertaking a biochemistry course as part of their vet course. It explains all of the crucial biochemical processes and pathways relevant to vet science concisely and clearly, and is very useful when writing essays.

    Was this review helpful? Yes  No   Report this review
Sort by: Showing 1 Customer Reviews

If you find inappropriate content, please report it to Barnes & Noble
Why is this product inappropriate?
Comments (optional)