Biochemistry of Redox Reactions / Edition 1

Biochemistry of Redox Reactions / Edition 1

by Bernard Testa
     
 

In the present volume, the first in the Series The Metabolism of Drugs and Other Xenobiotics, Professor Testa discusses the molecular and biochemical aspects of reactions of oxidation and reduction. While an encyclopaedic treatment is avoided, the covered topics include biochemical properties of the enzymes/isoenzymes, drug-enzyme interactions, the various

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Overview

In the present volume, the first in the Series The Metabolism of Drugs and Other Xenobiotics, Professor Testa discusses the molecular and biochemical aspects of reactions of oxidation and reduction. While an encyclopaedic treatment is avoided, the covered topics include biochemical properties of the enzymes/isoenzymes, drug-enzyme interactions, the various chemical reactions catalyzed by the enzyme (s), reaction mechanisms and catalytic cycles, regio- and stereoselectivities, structure-metabolism relationships, the reactivity of metabolic intermediates and molecular aspects of toxication and detoxication, as well as molecular mechanisms of direct and indirect enzyme inhibition. The classification of matters is based firstly on enzymes and their reactions, and secondly on the types of target groups being transformed, with carefully selected examples illustrating the reactions under discussion. Such a treatment has heuristic value since it renders the reader capable of educated guesses on the metabolism of other or novel drugs. Forthcoming volumes in the Series will present reactions of hydration and conjugation, and the biological regulations and consequences of xenobiotic metabolism.

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Product Details

ISBN-13:
9780126853919
Publisher:
Elsevier Science
Publication date:
10/25/1994
Series:
Metabolism of Drugs and Other Xenobiotics Series
Edition description:
Large Print
Pages:
471
Product dimensions:
0.99(w) x 7.44(h) x 9.69(d)

Table of Contents

Xenobiotic Metabolism: The Global View.
Xenobiotic Metabolism: The Biochemical View.
Dehydrogenation of Alcohols and Aldehydes, Carbonyl Reduction.
The Nature and Functioning of Cytochromes P450 and Flavin-Containing-Monooxygenases.
Carbon Oxidations Catalyzed by Cytochromes P450.
Monooxygenase-Catalyzed N-C Cleavage.
Monooxygenase-Catalyzed Oxidation of Oxygen- and Sulfur-Containing Compounds.
Oxidative Dehalogenation and Dealkylation of Organometallics.
Oxidations Catalyzed by Various Oxidases and Monooxygenases.
Reactions Catalyzed by Peroxidases.
Oxidation of Mercury, Silicon, Phosphorus, Arsenic, Selenium, and Halogens.
Reductions Catalyzed by Cytochrome P450 and Other Oxidoreductases.
Various Enzymatic and Nonenzymatic Reactions.
Conclusion and Outlook.

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