Biochemistry of Signal Transduction and Regulation / Edition 2

Biochemistry of Signal Transduction and Regulation / Edition 2

by Gerhard Krauss, Nancy Schonbrunner, Bonnie L. Cooper
     
 

Intracellular signal transduction, regulation of cellular activities, tumor formation, apoptosis - how do they work?" "Over the last decade there has been great progress in the understanding of the molecular basis of signal transduction, and many facts are now basic knowledge for every medicinal chemist, biochemist, and biologist. Since an integral description of… See more details below

Overview

Intracellular signal transduction, regulation of cellular activities, tumor formation, apoptosis - how do they work?" "Over the last decade there has been great progress in the understanding of the molecular basis of signal transduction, and many facts are now basic knowledge for every medicinal chemist, biochemist, and biologist. Since an integral description of cellular regulation and signal transduction is scarcely covered in textbooks, this book fills a real gap. Starting from the principles of gene regulation and regulation of enzyme activity, the topics of this book cover function, structure, and integral construction of signalling pathways plus a detailed description of the various types of carriers such as second messengers, protein kinases, and transmembrane receptors. Central cellular processes like cell cycle regulation, oncogenesis, and apoptosis are discussed in light of the properties of the signalling molecules involved. The author relates the observed biological phenomena to the underlying biochemical processes.

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Product Details

ISBN-13:
9783527303786
Publisher:
Wiley, John & Sons, Incorporated
Publication date:
09/06/2001
Edition description:
2ND
Pages:
528
Product dimensions:
6.75(w) x 9.78(h) x 1.04(d)

Table of Contents

Preface
1The Regulation of Gene Expression1
2The Regulation of Enzyme Activity89
3Structure and Function of Signal Pathways115
4Signaling by Nuclear Receptors151
5G Protein-Coupled Transmission Pathway179
6Intracellular Messenger Substances: Second Messengers231
7Ser/Thr-specific Protein Kinases and Protein Phosphatases269
8Signal Transmission via Transmembrane Receptors with Tyrosine-Specific Protein Kinase Activity311
9Signal Transmission via Ras Proteins355
10Intracellular Signal Transduction: the Protein Cascades of the MAP Kinase Pathways383
11Membrane Receptors with Associated Tyrosine Kinase Activity395
12Other Receptor Classes417
13Regulation of the Cell Cycle429
14Malfunction of Signaling Pathways and Tumorigenesis: Oncogenes and Tumor Suppressor Genes469
15Apoptosis511
Index533

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