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More About This Textbook
Overview
Bioenergetics is the study of the way biological systems, usually at the molecular level, utilize and convert energy in order to drive the biochemical reactions that constitute life. However, because of its often quantitative basis and the amount of technical jargon, the subject tends to alienate and intimidate students. This beautifully illustrated text has a lucid and logical approach to the subject. The text uses the modern perspective throughout so that the student is given an easily assimilable, logical introduction to the important concepts of the subject, particulary the core concept, the 'chemiosmotic theory'. It has been specifically designed to make information easily accessible by devoting each double-page spread to one topic. Within the spread, a variety of carefully constructed diagrams present information in a concise and innovative manner. The text is further enhanced by a comprehensive guide to additional reading.
Editorial Reviews
From The Critics
Reviewer: Gene A. Homandberg, PhD (Rush Medical College of Rush University)Description: This monograph is a concise yet broad and detailed introduction to various aspects of bioenergetics, beginning with a brief introduction to thermodynamics and continuing with more than 40 summaries of divergent but relevant topics. Some of the topics are chemical and electrochemical potentials, redox potentials, cofactors in redox reactions, the mitochondrial respiratory chain, bacterial respiratory systems, photosynthesis, proton gradients, ATP synthesis pathways, mitochondrial defects in diseases, use of proton gradients for heat generation and bacterial motion, and structural and functional aspects of ATPases. The monograph finishes with an interesting discussion of the evolution of bioenergetic systems.
Purpose: The purpose of this overview is to cover in summary fashion a broad range of topics related to bioenergetics from the perspective of structure and function relationships. With more than 40 divergent topics, this overview is fairly comprehensive. Although the brevity of these sections has led to a very condensed text, the sections remain very readable but yet of more than sufficient depth for a graduate level text.
Audience: The audience is meant to be biochemistry and biology graduate students. The monograph could be presented as an adjunct reference in a biochemistry or cell biology course or as a primary text in a bioenergetics course. Further, because the chapters contain sufficient detail but are concise, the information in some sections would be sufficient supplementary material in many different types of courses, including medical biochemistry.
Features: This book features short two to three page summaries, many illustrations, and a reading list.
Assessment: This monograph is fairly unique because it focuses on bioenergetics without the length and detail of texts with larger scopes. The brevity of the chapters should make this text attractive and very readable for most students. This monograph is highly recommended as a course textbook or for anyone needing a concise but sufficiently detailed overview of bioenergetics.
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Table of Contents
Scope of bioenergetics.
The 'universal' view of energy.
The 'local' view of energy.
Equilibrium and equilibrium constants.
Sources of biological energy - quantitation.
Direct coupling of oxidation to anhydride formation.
Oxygen as an oxidising agent.
Respiratory carriers.
Respiratory chain (mitochondrial).
Respiratory assemblages (mitochondrial).
Mechanism of electron flow between proteins.
Variations within respiratory chains.
Light trapping and water splitting in chloroplasts.
Reaction centre structure.
Organisation of membrane proteins (chloroplast).
Photosynthetic bacteria.
Concepts of energy transduction- redox-anhydride bond energy.
Transfer via H+gradient -.
I. Qualitative aspects.
II. Kinetic aspects.
Quantitative aspects -.
I. H+/O ratio.
II. DGp/DMH+.
How does electron transfer generate H+ (I) + (II).
ATP synthase complex.
F1 structure.
F0 structure.
Coupling H+ gradient to ATP synthesis - energetics.
structural aspects.
Integration with cytoplasm - mitochondria.
Aspects of control - qualitative:quantitative.
Integration of cytoplasm/control - chloroplasts.
Uncouplers and ionophores in studies of phosphorylation.
Mitochondrial defects.
Alternative uses of H+ gradient.
Alternative gradient production.
ATP driven ion pumps - a broader perspective.
E-P pumps.
Evolution of pumps.
Evolution of organelles