Bioinformatics and Drug Discovery / Edition 1

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Recent advances in drug discovery have been rapid. The second edition of Bioinformatics and Drug Discovery has been completely updated to include topics that range from new technologies in target identification, genomic analysis, cheminformatics, protein analysis, and network or pathway analysis. Each chapter provides an extended introduction that describes the theory and application of the technology. In the second part of each chapter, detailed procedures related to the use of these technologies and software have been incorporated. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.

Thorough and intuitive, Bioinformatics and Drug Discovery, Second Edition seeks to aid scientists in the further study of the rapidly expanding field of drug discovery.

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Editorial Reviews

Doody's Review Service
Reviewer: Julia Yue Cui, PhD (University of Kansas Medical Center)
Description: This is a timely and comprehensive update of recent molecular technologies and computational methods for drug discovery, ranging from target identification and second-generation sequencing and genomic analysis to cheminformatics, protein analysis, and pathway analysis. It uniquely provides an extended introduction to the principles and application of the technology, as well as detailed procedures related to the molecular biology and computational approaches, making it an excellent reference for both investigators and technical personnel in areas of drug discovery. The first edition was published in 2006.
Purpose: The purpose of the second edition is to detail the most recent technologies in drug discovery and to efficiently familiarize scientists with the principles and hands-on procedures of these new molecular and computational tools. These are worthy objectives, considering the rapid advances in technologies for drug discovery since the first edition, and this book in general successfully meets them.
Audience: Intended for investigators in the area of drug discovery, it is a helpful resource for principal investigators in both molecular biology and bioinformatics, and is especially helpful for technical personnel who conduct the procedures. Chapters are written by experts in the various technologies.
Features: The book covers the basic principles, available tools, and detailed hands-on procedures for new technologies, such as high throughput screening of chemicals, genomic analysis, gene expression analysis, protein interactions, and interactome analysis. The best feature of the book is that it provides lists of available practical tools as well as detailed procedures related to the use of these technologies and software, providing necessary guidance to investigators who have a practical problem to solve. A minor shortcoming is that for a given technology, it lacks a comprehensive description and/or examples of all possible tools. For example, chapter 5 focuses on the SOLiD sequencing platform, ignoring other commonly used sequencing platforms, such as Illumina HiSeq2000, Ion Torrent, or PacBio. Because of this, the book might be less helpful for students and junior scientists who would like to see the big picture of the principles and mechanisms in these technologies.
Assessment: In general, this is an excellent collection of the latest molecular and bioinformatics methods to advance drug discovery, from genomic analysis to protein modeling to drug target identification. Compared to other books in this field, this one provides a more detailed description of the procedures for these technologies. This edition is a timely and necessary update of the tools that have been developed since the first edition (especially the second generation sequencing technology).
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Product Details

  • ISBN-13: 9781617375095
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/9/2010
  • Series: Methods in Molecular Biology Series, #316
  • Edition description: Softcover reprint of hardcover 1st ed. 2006
  • Edition number: 1
  • Pages: 444
  • Product dimensions: 9.00 (w) x 6.00 (h) x 1.02 (d)

Table of Contents

New Strategies in Drug Discovery

Eliot H. Ohlstein, Anthony G. Johnson, John D. Elliot, and Anne M. Romanic

Basic Microarray Analysis: Strategies for Successful Experiments

Scott A. Ness

From Microarray to Biological Networks: Analysis of Gene Expression Profiles

Xiwei Wu and T. Gregory Dewey

Microarray Analysis in Drug Discovery and Clinical Applications

Siqun Wang and Qiong Cheng

Ontology-Driven Approaches to Analyzing Data in Functional Genomics

Francisco Azuaje, Fatima Al-Shahrour, and Joaquin Dopazo

Gene Evolution and Drug Discovery

James O. McInerney, Caroline S. Finnerty, Jennifer M. Commins, and Gayle K. Philip

Standardization of Microarray and Pharmacogenomics Data

Casey S. Husser, Jeffrey R. Buchhalter, O. Scott Raffo, Amnon Shabo, Steven H. Brown, Karen E. Lee, and Peter L. Elkin

Clinical Applications of Bioinformatics, Genomics, and Pharmacogenomics

Omer Iqbal and Jawed Fareed

Protein Interactions Probed With Mass Spectrometry

Suma Kaveti and John R. Engen

Discovering New Drug Targeting Sites on Flexible Multidomain Protein Kinases: Combining Segmental Isotopic and Site-Directed Spin Labeling for Nuclear Magnetic Resonance Dectection of Interfacial Clefts

Thomas K. Harris

Nuclear Magnetic Resonance-Based Screening Methods for Drug Discovery

Laurel O. Sillerud and Richard S. Larson

Receptor-Binding Sites: Bioinformatic Approaches

Darren R. Flower

In Silico Protein Design: Fitting Sequence Onto Structure

Bassil I. Dahiyat

Chemical Database Preparation for Compound Acquisition or Virtual Screening

Cristian G. Bologna, Marius M. Olah, and Tudor I. Oprea

Bioinformatics Platform Development: From Gene to Lead Compound

Alexis S. Ivanov, Alexander V. Veselovsky, Alexander V. Dubanov, and Vladlen S. Skvortsov


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