Bioinformatics: A Practical Guide to the Analysis of Gene and Proteins / Edition 1by Andreas D. Baxevanis
Bioinformatics A Practical Guide to the Analysis of Genes and Proteins Edited by Andreas D. Baxevanis and B. F. Francis Ouellette With the explosion of sequence and structural information available to researchers, the field of bioinformatics is playing an increasingly large role in the study of fundamental biological problems. The challenge facing biologists,… See more details below
Bioinformatics A Practical Guide to the Analysis of Genes and Proteins Edited by Andreas D. Baxevanis and B. F. Francis Ouellette With the explosion of sequence and structural information available to researchers, the field of bioinformatics is playing an increasingly large role in the study of fundamental biological problems. The challenge facing biologists, especially in light of the vast amount of data being produced by the Human Genome Project and other systematic sequencing efforts, will be the effective utilization of sequence-based information on two fronts: first, to reveal previously unknown relationshipsranging from the identification of unknown genes to the prediction of protein structures; and, second, to use predictions and inferences made from these data to better design experiments in the laboratory as genome projects move from the realm of structural genomics into one of functional genomics. Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins makes computational biology accessible to scientists at all levels of expertise, including those with no formal computer training, by taking an example-driven approach accompanied by a large number of illustrations. By focusing in on a selected group of powerful methods, the book cuts through the overwhelming array of existing tools and databases, helping the reader quickly design and implement a successful sequence analysis strategy. Presented by leading authorities in computational biology, this edited volume covers a broad range of topics in bioinformatics, beginning with a gentle reintroduction to the use of software and Internet resources and culminating with a discussion of how readers can submit their own sequence data to the public databases. Other topics covered in this volume include:
- The GenBank sequence database
- Structural databases and basic tools for viewing three-dimensional structures
- Sequence analysis using the integrated GCG package
- Information retrieval from biological databases
- The NCBI data model
- Effective methodologies for performing sequence-based database searches
- Practical aspects of multiple sequence alignment
- Phylogenetic analysis
- Predictive methods using protein and nucleotide sequences
- Navigating public physical mapping databases
- The AceDB database for organizing and presenting genome information
Table of Contents
The Internet and the Biologist (A. Baxevanis).
The GenBank Sequence Database (B. Ouellette).
Structure Databases (C. Hogue & S. Bryant).
Sequence Analysis Using GCG (B. Butler).
Information Retrieval from Biological Databases (A. Baxevanis).
The NCBI Data Model (J. Ostell & J. Kans).
Sequence Alignment and Database Searching (G. Schuler).
Practical Aspects of Multiple Sequence Alignment (A. Baxevanis).
Phylogenetic Analysis (M. Hershkovitz & D. Leipe).
Predictive Methods Using Nucleotide Sequences (J. Fickett).
Predictive Methods Using Protein Sequences (A. Baxevanis & D. Landsman).
Of Mice and Men: Navigating Public Physical Mapping Databases (L. Stein) .
ACEDB: A Database for Genome Information (S. Walsh, et al.).
Submitting DNA Sequence to the Databases (J. Kans & B. Ouellette) .
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