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Bioinformatics: A Practical Guide to the Analysis of Gene and Proteins / Edition 1

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"A reference that should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data" --Science

As the Human Genome Project continues to generate raw sequence information, the most successful scientists will be those who can provide a biological interpretation of that data. This practical guide helps the molecular biologist design and implement a successful sequence analysis strategy, utilizing the overwhelming array of tools available, including Internet resources. A real advantage of this book over its competitors is its accessibility to the average biologist with no training in computational methods.

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Editorial Reviews

FEBS Letters
...a worthwhile addition to the library...
Quarterly Review of Biology
This book is a rich source of information on an exciting new research field. The book's practical orientation and lack of mathematical detail should make it particularly appealing to professional geneticists.
A reference that should be in the personal library of any biologist who uses the Internet for the analysis of DNA and protein sequence data.
Presents fourteen chapters on tools and databases used in bioinformatics, loosely defined as the intersection of molecular and computational biology. With the goal of helping the reader design and implement a successful sequence analysis strategy, topics covered include: using software and Internet resources, submitting DNA sequences to databases, information retrieval from databases, phylogenetic analysis, a database for genome information called ACeDB, and practical aspects of multiple sequence alignment. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780471324416
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 7/1/1998
  • Series: Methods of Biochemical Analysis Series , #39
  • Edition description: New Edition Due 03/2001
  • Edition number: 1
  • Pages: 374
  • Product dimensions: 7.28 (w) x 10.24 (h) x 0.98 (d)

Table of Contents

1 The Internet and the Biologist 1
2 The GenBank Sequence Database 16
3 Structure Databases 46
4 Sequence Analysis Using GCG 74
5 Information Retrieval from Biological Databases 98
6 The NCBI Data Model 121
7 Sequence Alignment and Database Searching 145
8 Practical Aspects of Multiple Sequence Alignment 172
9 Phylogenetic Analysis 189
10 Predictive Methods Using Nucleotide Sequences 231
11 Predictive Methods Using Protein Sequences 246
12 Of Mice and Men: Navigating Public Physical Mapping Databases 268
13 ACEDB: A Database for Genome Information 299
14 Submitting DNA Sequence to the Databases 319
App. 1: Glossary 355
App. 2 Sample Sequence File Formats 359
Index 363
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