Bioinformatics in Cancer and Cancer Therapy / Edition 1

Bioinformatics in Cancer and Cancer Therapy / Edition 1

by Gavin J. Gordon
     
 

Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Although no single person or group started the field wholly on their own, Temple Smith, Ph.D., a professor at Boston University, is generally credited with coining the term. Bioinformatics… See more details below

Overview

Bioinformatics can be loosely defined as the collection, classification, storage, and analysis of biochemical and biological information using computers and mathematical algorithms. Although no single person or group started the field wholly on their own, Temple Smith, Ph.D., a professor at Boston University, is generally credited with coining the term. Bioinformatics represents a marriage of biology, medicine, computer science, physics, and mathematics, fields of study that have historically existed as mutually exclusive disciplines.

Concurrently, bioinformatics has vaulted into the public’s eye in lay newspapers and magazines, most notably in the area of (personalized) DNA sequencing. The combined result is that bioinformatics is being heralded as a panacea to the current limitations in the clinical management of cancer. While certainly over optimistic in some regards, this designation is not without promise particularly in the area of cancer diagnosis and prognosis.

The focus of this book is to: i) to provide a historical and technical perspective on the analytical techniques, methodologies, and platforms used in bioinformatics experiments, ii) to show how a bioinformatics approach has been used to characterize various cancer-related processes, and iii) to demonstrate how a bioinformatics approach is being used to bridge basic science and the clinical arena to positively impact patient care and management.

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Product Details

ISBN-13:
9781588297532
Publisher:
Springer-Verlag New York, LLC
Publication date:
12/04/2008
Series:
Cancer Drug Discovery and Development Series
Edition description:
2009
Pages:
198
Product dimensions:
7.60(w) x 10.30(h) x 0.60(d)

Table of Contents

Table of Contents for Bioinformatics in Cancer and Cancer Therapy

Preface

Chapter 1: The Emergence of Bioinformatics: Historical Perspective, Quick Overview and Future Trends

Christos A. Ouzounis

Chapter 2: The Statistical Design and Interpretation of Microarray Experiments

Kevin K. Dobbin and Richard M. Simon

Chapter 3: Whole Genome Analysis of Cancer

Steven A. Enkemann, James M. McLoughlin, Eric H. Jensen, and Timothy J. Yeatman

Chapter 4: Bioinformatics Approaches to the Analysis of the Transcriptome of Animal Models of Cancer

Mark J. Hoenerhoff, Aleksandra A. Michalowska, Ting-Hu Qiu, and Jeffery E. Green

Chapter 5: Significance of Aberrant Expression of MicroRNAs in Cancer Cells

George A. Calin, Chang-gong Liu, Manuela Ferracin, Stefano Volinia, Massimo Negrini, and Carlo M. Croce

Chapter 6: Proteomic Methods in Cancer Research

Scot Weinberger and Egisto Boschetti

Chapter 7: Comprehensive Genomic Profiling for Biomarker Discovery for Cancer Detection, Diagnostics and Prognostics

Xiaofeng Zhou, Nagesh P. Rao, Steven W. Cole, and David T. Wong

Chapter 8: Gene Expression Profiling of the Leukemias: Oncogenesis, Drug Responsiveness, and Prediction of Clinical Outcome

Lars Bullinger, Hartmut Dohner, and Jonathan R. Pollack

Chapter 9: Personalized Medicine in the Clinical Management of Colorectal Cancer

Anthony El-Khoueiry and Heinz Josef Lenz

Chapter 10: PIK3CA Gene Alterations in Human Cancers

Sérgia Velho, Carla Oliveira, and Raquel Seruca

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