Bioinformatics: Volume II: Structure, Function and Applications / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$159.00
Used and New from Other Sellers
Used and New from Other Sellers
from $112.16
Usually ships in 1-2 business days
(Save 29%)
Other sellers (Hardcover)
  • All (6) from $112.16   
  • New (4) from $112.16   
  • Used (2) from $158.99   

Overview

*Encompasses topics from across the diverse field of bioinformatics through its broad scope approach *Over 80 authors from around the globe contribute to the two volumes, including many leading experts *An inter-disciplinary collaboration involving biologists, biochemists, physicists, mathematicians, statisticians and computer scientists *Contains simplified descriptions, requiring a minimum of background knowledge, amenable to students and beginners in bioinformatics *References a wide variety of software tools and scripts, available online Not only is the quantity of life science data expanding, but new types of biological data continue to be introduced as a result of technological development and a growing understanding of biological systems. Methods for analyzing these data are an increasingly important component of modern biological research. In Bioinformatics, leading researchers in the field provide a selection of the most useful and widely applicable methods, able to be applied as is, or with minor variations, to many specific problems. Volume II: Structure, Function and Applications contains methods pertinent to the prediction of protein and RNA structures and the analysis and classification of structures, methods for inferring the function of previously identified genomic elements, chiefly protein-coding genes, medical applications in diagnostics and drug discovery, and "meta-methods" for developers of bioinformatics algorithms. As a volume of the highly successful Methods in Molecular BiologyT series, this work provides the kind of detailed description and implementation advice that is crucial for getting optimal results. Comprehensive and cutting-edge, Bioinformatics: Volume II: Structure, Function and Applications is an ideal reference for all scientists involved with the ever-growing array of data in the expanding field of life science. Written for: Molecular biologists, bioinformaticians, geneticists, microbiologi

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Basabi Rana, Ph.D.(Loyola University Stritch School of Medicine)
Description: In general, this book describes some of the most useful and widely used techniques in the field of bioinformatics. With a significant number of contributing authors, it covers a wide variety of topics to satisfy the large audience involved in using and developing bioinformatics. Of particular interest are the clinical correlations and the possible implication of bioinformatics in diagnostics and drug design.
Purpose: As indicated by the editor, the authors of this book provide a "detailed description and implementation advice" for a variety of techniques used in the field of molecular biology. These will be of extreme importance to those involved in utilization and development of bioinformatics methods.
Audience: The book is written for students and beginning level bioinformatics researchers. The authors are authorities in the fields of molecular biology and bioinformatics.
Features: The first section on structures focuses primarily on methods used for prediction of protein structure and classification of protein domains. Section II, on inferring function, includes some of the well established techniques based on homology, "Rosetta stone" method, phylogenetic profiling, and phylogenetic shadowing. It also describes methods for predicting regulatory elements, expression patterns, complex formation, and integration of genomics data. Section III, on applications and disease, contains more applied diagnostic aspects and drug discovery. The topics in this section include the importance of microarray data in diagnostics, combinatorial optimization models for finding genetic signatures from gene expression datasets, and utilization in a rodent model of Parkinson's disease. The final section describes analytical and computational methods, which are composed of meta-methods that could be very important for the users and developers of bioinformatics. Inclusion of more illustrations would facilitate understanding.
Assessment: This is a good reference in the field of bioinformatics, particularly for those who are just starting out.
Read More Show Less

Product Details

  • ISBN-13: 9781603274289
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 5/22/2008
  • Series: Methods in Molecular Biology Series, #453
  • Edition description: 2008
  • Edition number: 1
  • Pages: 506
  • Product dimensions: 7.30 (w) x 10.20 (h) x 1.40 (d)

Table of Contents

Bioinformatics: Volume II: Structure, Function and Applications

Section I: Structures

Chapter 1. UNAFold: Software for Nucleic Acid Folding and Hybridization

Nicholas R. Markham and Michael Zuker

Chapter 2. Protein Structure Prediction

Bissan Al-Lazikani, Emma E. Hill and Veronica Morea

Chapter 3. An Introduction to Protein Contact Prediction

Nicholas Hamilton and Thomas Huber

Chapter 4. Analysis of Mass Spectrometry Data in Proteomics

Rune Matthiesen and Ole N. Jensen

Chapter 5. The Classification of Protein Domains

Russell L. Marsden and Christine A. Orengo

Section II: Inferring Function

Chapter 6. Inferring Function from Homology

Richard D. Emes

Chapter 7. The Rosetta Stone Method

Shailesh V. Date

Chapter 8. Inferring Functional Relationships from Conservation of Gene Order

Gabriel Moreno-Hagelsieb

Chapter 9. Phylogenetic Profiling

Shailesh V. Date, Jose M Peregrin-Alvarez

Chapter 10. Phylogenetic Shadowing: Sequence Comparisons of Multiple Primate Species

Dario Boffelli

Chapter 11. Prediction of Regulatory Elements

Albin Sandelin

Chapter 12. Expression and Microarrays

Joaquin Dopazo and Fatima Al-Shahrour

Chapter 13. Identifying Components of Complexes

Nicolas Goffard and Georg Weiller

Chapter 14. Integrating Functional Genomics Data

Insuk Lee and Edward M. Marcotte

Section III: Applications and Disease

Chapter 15. Computational Diagnostics with Gene Expression Profiles

Claudio Lottaz, Dennis Kostka, Florian Markowetz and Rainer Spang

Chapter 16. Analysis of Quantitative Trait Loci

Mario Falchi

Chapter 17. Molecular Similarity Concepts and Search Calculations

Jens Auer and Jürgen Bajorath

Chapter 18. Optimization of the MAD Algorithm for Virtual Screening

Hanna Eckert and Jürgen Bajorath

Chapter 19. Combinatorial Optimization Models for Finding Genetic Signatures from Gene Expression Datasets

Regina Berretta, Wagner Costa and Pablo Moscato

Chapter 20. Genetic Signatures for a Rodent Model of Parkinson's Disease Using Combinatorial Optimization Methods

Mou'ath Hourani, Regina Berretta, Alexandre Mendes and Pablo Moscato

Section IV: Analytical and Computational Methods

Chapter 21. Developing Fixed-Parameter Algorithms to Solve Combinatorially Explosive Biological Problems

Falk Huffner, Rolf Niedermeier and Sebastian Wernicke

Chapter 22. Clustering

Geoffrey J. McLachlan, R. W. Bean and S. K. Ng

Chapter 23. Visualization

Falk Schreiber

Chapter 24. Constructing Computational Pipelines

Mark Halling-Brown and Adrian J. Shepherd

Chapter 25. Text mining

Andrew B. Clegg and Adrian J. Shepherd

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)