Biological Psychiatry / Edition 2

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1996 Trade paperback 2nd ed. New. No dust jacket as issued. Never used Trade paperback (US). Glued binding. 480 p. Contains: Illustrations. Audience: General/trade.

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This book provides an authoritative summary of the current status of the field of biological psychiatry, integrating material from the basic neuroscience investigations and clinical case studies. It offers a chapter on pharmacotherapy which outlines current consensus in the field. It contains material on such fast-moving areas as neuroimaging, panic and obsessive-compulsive disorders, as well as reports of major developments in schizophrenia, epilepsy, and Alzheimer's disease. It bridges the gap between research and clinical application.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Michael Joel Schrift, D.O., M.A.(University of Illinois at Chicago College of Medicine)
Description: This is the second edition of this well-received textbook on the neurobiological aspects of psychiatry and is written by a well-known and influential researcher and clinician in the field.
Purpose: The purpose of this second edition is to document the advances in neuroanatomy, neurochemistry, genetics, and brain imaging that have occurred since Dr. Trimble wrote the first edition of his book. Dr. Trimble believes (as I do) that psychological theories of pathogenesis have been overtaken by a wealth of neurochemical and neuropathological hypotheses and findings. This book explains and teaches the reader these current theories in a very readable text.
Audience: The intended audience includes medical students, residents in psychiatry training programs, practicing psychiatrists, and psychologists interested in the current state of psychiatry. I would recommend this book to any individual involved in the care of the mentally ill. It is a shame that the recent neurobiological understanding of these illnesses has not filtered down or has been ignored by nonphysician mental health workers.
Features: The book features 12 chapters covering the important aspects of biological psychiatry (the title now is anachronistic). The book ends with a reference section and an index. The tables and figures are useful.
Assessment: The second edition of this book, which I looked forward to reading, was not disappointing. I highly recommend it.
A comprehensive survey of concepts in biological psychology. Coverage includes principles of brain physiology, chemistry, and anatory; disorders of the limbic system; personality disorders; schizophrenia; epilepsies; and biological treatments. This second edition reflects the major advances in neuroanatomy, neurochemistry, genetics, and imaging techniques since the first edition in 1987. Of interest to advanced students, researchers, and clinicians psychiatry, psychology, and mental health care. Annotation c. Book News, Inc., Portland, OR (
From the Publisher
“This book therefore may be valuable to those engaged in clinical practice who wish to familiarize themselves with some of the basic concepts behind modern biological psychiatric research and the recent history of the field.” (Psychological Medicine, 2012)

"If you are going to choose where to fork out the money, it would be here, for the most practical understanding of brain-behavior science, and these authors I am sure will continue to be leaders in this field, with perhaps only Lishman challenging them for the buck." (Metapsychology, 25 June 2011)

"As in the earlier editions of the book, there are comprehensive reviews and explanations of the latest advances in neurochemistry, neuroanatomy, genetics and brain imaging descriptions not only of methodologies but also of the application of these in clinical settings." (AllVoices, 16 February 2011)

"An important contribution that should be read by psychopharmacologists, psychiatrists, neurologists and neuroscientists who wish to obtain an interesting and well-written account of the subject." (Human Psychopharmacology, 2010)

"Writing for medical students and for researchers and practitioners in fields that touch upon mental health, they begin by exploring principles of brain function and structure from perspectives of genetics, physiology, chemistry, and anatomy. Then they consider important brain-behavior relationships, and classifications and clinical investigations. Having set the stage, they proceed to describe biological aspects of personality disorders, anxiety disorders, the schizophrenias, affective disorders, the addictions and disorders of motivation, epilepsy, and the dementias." (SciTech Book News, December 2010)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780471953746
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/28/1996
  • Edition description: REV
  • Edition number: 2
  • Pages: 480
  • Product dimensions: 5.96 (w) x 8.93 (h) x 1.15 (d)

Meet the Author

Professor Trimble was for many years Professor ofBehavioural Neurology and Consultant Physician to the Department ofPsychological Medicine at the National Hospital Queen Square,London. He now holds emeritus status at the above institutions. Hestudied general medicine, obtaining membership of the Royal Collegeof Physicians before going to the National Hospital Queen Squareand then the Maudsley Hospital to advance his training in neurologyand psychiatry. Following an internship in psychiatry at the JohnsHopkins Hospital, Baltimore, he returned to the National Hospitalto pursue a career in neuropsychiatry. He set up a research groupwith main interests in the interface disorders between neurologyand psychiatry, reflected in the developing recognition ofneuropsychiatry and behavioural neurology as independentdisciplines. The research group (Raymond-Way Unit) explored thebehavioural consequences of neurological disorders and theirtreatment, with a major interest in epilepsy and movementdisorders. His current writing and academic interests involveteaching and lecturing on neuroanatomical concepts relevant tounderstanding behaviour and its variations, in particular with aninterest in neuroaesthetics and neurotheology, namely the cerebralbasis of artistic and religious experiences.

Dr. George received his medical degree from the MedicalUniversity of South Carolina in Charleston in 1985, where hecontinued with dual residencies in neurology and psychiatry. He isboard certified in both areas. He worked for one year (1990-91) asa Visiting Research Fellow in the Raymond Way NeuropsychiatryResearch Group at the Institute of Neurology, London. He andProfessor Trimble used pharmacology and imaging to study theoverlaps between Obsessive-Compulsive Disorder and Gilles de laTourette Syndrome. During this year he also worked on newfunctional imaging techniques (SPECT and PET) at the Institute ofNuclear Medicine, University College of London and Middlesex Schoolof Medicine, London. He wrote one of the first textbooks in the newarea of brain activation and imaging. Dr George then moved toWashington, DC, working with Dr. Robert Post in the BiologicalPsychiatry Branch of the Intramural National Institute of MentalHealth.  He was one of the first to use functional imaging(particularly oxygen PET) to assess brain changes associated withnormal emotions, as well as using imaging to understand brainchanges which occur in depression and mania. This imaging workdirectly led to his pioneering use of transcranial magneticstimulation (TMS) as a probe of neuronal circuits regulating mood,and to clinical trials using TMS as an antidepressant. In 2008prefrontal TMS was FDA approved as an antidepressant treatment. In1995 he moved back to Charleston and built the functionalneuroimaging division and brain stimulation laboratories. Thisimaging group has grown into the MUSC Center for Advanced ImagingResearch, which is now part of the SC Brain Imaging Center ofExcellence. He continues to use imaging and non-invasivestimulation, either separately or more recently in combination, tounderstand the brain regions involved in emotion regulation inhealth and disease. In 1998, he pioneered another new treatment forresistant depression, vagus nerve stimulation, that was recentlyFDA approved. He and his group have used MRI imaging to understandbrain stimulation brain effects. He is on several editorial reviewboards, and has published over 200 scientific articles, and haswritten or edited 5 books. He is the editor-in-chief of a newjournal, Brain Stimulation.
He has received several international awards, including the WorldFederation of Societies of Biological Psychiatry LifetimeAchievement Award (2007), the NARSAD Falcone Award (2008) and hewas honored as one of 14 'Pioneers of Medical Progress' saluted inthe August 2009 edition of US News & World Report.

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Table of Contents

Historical Introduction.
Concepts of Disease and Classification.
Principles of Brain Function and Structure of Relevance for Psychiatry: (1) Physiology and Chemistry.
Principles of Brain Function and Structure of Relevance for Psychiatry: (2) Anatomy.
Disorders of the Limbic System.
Personality Disorders and the Neuroses.
Affective Disorders.
The Dementias.
Biological Treatments.
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