Biological Sequence Analysis: Probabilistic Models of Proteins and Nucleic Acids

by Richard Durbin, Sean R. Eddy, Anders Krogh, Graeme Mitchison

Overview

Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

Product Details

ISBN-13:	9781107085015
Publisher:	Cambridge University Press
Publication date:	04/23/1998
Sold by:	Barnes & Noble
Format:	eBook
File size:	12 MB
Note:	This product may take a few minutes to download.

About the Author

Richard Durbin studied at Cambridge University and received his B.A. (Hons) in Mathematics in 1982. He continued at Harvard University (Biophysics) and later at the MRC Laboratory of Molecular Biology in Cambridge, where he was awarded his Ph.D. in July 1987 on "Studies on the Development and Organisation of the Nervous System of Caenorhabditis elegans". During 1990 to 1996 he worked at the same laboratory on informatics for genome data management and analysis, in particular on the genome database ACEDB together with Jean Thierry-Mieg.
Currently, Richard Durbin is Head of Informatics Division at the Sanger Centre.

Table of Contents

1. Introduction; 2. Pairwise sequence alignment; 3. Multiple alignments; 4. Hidden Markov models; 5. Hidden Markov models applied to biological sequences; 6. The Chomsky hierarchy of formal grammars; 7. RNA and stochastic context-free grammars; 8. Phylogenetic trees; 9. Phylogeny and alignment; Index.

What People are Saying About This

From the Publisher

"The book is amply illustrated with biological applications and examples." Cell

"...successfully integrates numerous probabilistic models with computational algorithms to solve molecular biology problems of sequence alignment...an excellent textbook selection for a course on bioinformatics and a very useful consultation book for a mathematician, statistician, or biometrician working in sequence alignment." Bulletin of Mathematical Biology

"This is one of the more rewarding books I have read within this field. My overall evaluation is that this book is very good and a must read for active participants in the field. In addition, it could be particularly useful for molecular biologists" Theoretical Population Biology

Editorial Reviews

The book is amply illustrated with biological applications and examples."
--Cell

"...successfully integrates numerous probabilistic models with computational algorithms to solve molecular biology problems of sequence alignment...an excellent textbook selection for a course on bioinformatics and a very useful consultation book for a mathematician, statistician, or biometrician working in sequence alignment."
--Bulletin of Mathematical Biology

"This is one of the more rewarding books I have read within this fieldoMy overall evaluation is that this book is very good and a must read for active participants in the field. In addition, it could be particularly useful for molecular biologists"
--Theoretical Population Biology

University Press Cambridge

"The book is amply illustrated with biological applications and examples." Cell

"...successfully integrates numerous probabilistic models with computational algorithms to solve molecular biology problems of sequence alignment...an excellent textbook selection for a course on bioinformatics and a very useful consultation book for a mathematician, statistician, or biometrician working in sequence alignment." Bulletin of Mathematical Biology

"This is one of the more rewarding books I have read within this field. My overall evaluation is that this book is very good and a must read for active participants in the field. In addition, it could be particularly useful for molecular biologists" Theoretical Population Biology

From the Publisher