Biological Weapons Defense: Infectious Disease and Counterbioterrorism / Edition 1

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Overview

Prominent experts in biodefense research-many from the US Army Medical Research Institute of Infectious Diseases-authoritatively delineate the universe of scientific, medical, and legal issues facing the biodefense research community. Regarding medical countermeasures and decontamination, the authors describe the treatment and pathogenesis of a variety of established pathogens (anthrax, plague, smallpox, Brucellosis, Glanders, and Coxiella burnettii) and review what is known about the aerosol route of infection and decontamination processes. They also examine how to discover the presence of these agents, or other previously unknown biological weapons, and detail the ongoing efforts to counter these agents, including proteomic and genomic analysis as a gateway to better diagnostics, therapeutics, vaccinations, genotyping, and forensics. Additional chapters discuss the development and use technology to identify and characterize these infectious organisms, emerging threats, and the development of countermeasures.

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Editorial Reviews

From the Publisher
From the reviews:

"Acts of bioterrorism have not happened since the end of World War II except the distribution of anthrax spores in the US postal system in 2001 … . This important book is dedicated and useful not only for governmental and public health workers but also for a broad group of readers up to practitioners who might come in contact with such events as the first ones." (Werner Köhler, International Journal of Medical Microbiology, Vol. 295, 2005)

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Product Details

  • ISBN-13: 9781588291844
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/10/2004
  • Series: Infectious Disease Series
  • Edition description: 2005
  • Edition number: 1
  • Pages: 598
  • Product dimensions: 10.00 (w) x 7.00 (h) x 1.31 (d)

Table of Contents

I. Preparation and Military Support for a Possible Bioterrorism Incident

Department of Defense Capabilities Supporting Bioterrorism Response
Anna Johnson-Winegar, Karl Semancik, Robert S. Borowski, Keith R. Vesely, Brenda Wyler, Matt Eussen, and John V. Wade

Modeling for Bioterrorism Incidents
Zygmunt F. Dembek

Biological Weapons Defense: Effect Levels
Ross D. LeClaire and M. Louise M. Pitt

II. Medical Countermeasures and Decontamination

Pathogenesis by Aerosol
M. Louise M. Pitt and Ross D. LeClaire

Bacillus anthracis and the Pathogenesis of Anthrax
Dominique M. Missiakas and Olaf Schneewind

Virologic and Pathogenic Aspects of the Variola Virus (Smallpox) as a Bioweapon
Robert G. Darling, Timothy H. Burgess, James V. Lawler, and Timothy P. Endy

Plague Vaccines: Retrospective Analysis and Future Developments
Jeffrey J. Adamovicz and Gerard P. Andrews

Medical Protection Against Brucellosis
David L. Hoover and Richard H. Borschel

Pathogenesis of and Immunity to Coxiella burnetii
David M. Waag and Herbert A. Thompson

Glanders: New Insights Into an Old Disease
David M. Waag and David DeShazer

Medical Countermeasures for Filoviruses and Other Viral Agents
Alan Schmaljohn and Michael Hevey

Medical Defense Against Protein Toxin Weapons: Review and Perspective
Charles B. Millard

Antimicrobials for Biological Warfare Agents
Jon B. Woods

Nonspecific Immunomodulator Therapy: CpG
D. G. Cerys Rees, Arthur M. Krieg, and Richard W. Titball

Decontamination
Robert J. Hawley and Joseph P. Kozlovac

III. Emerging Threats and Future Preparation

Definition and Overview of Emerging Threats
Luther E. Lindler, Eileen Choffnes, and George W. Korch

Department of Defense Global Emerging Infections System Programs in Biodefense
Julie A. Pavlin and Patrick W. Kelley

Information Resources and Database Development for Defense Against Biological Weapons
Frank J. Lebeda, Murray Wolinsky, and Elliot J. Lefkowitz

Genomic Efforts With Biodefense Pathogens
Rekha Seshadri, Timothy D. Read, William C. Nierman, and Ian T. Paulsen

Genomics for Biodefense: Exploiting the Francisella tularensis Genome Sequence
Siv G. E. Andersson, Mats Forsman, Petra C. F. Oyston, and Richard W. Titball

Genetic Fingerprinting of Biodefense Pathogens for Epidemiology and Forensic Investigation
Luther E. Lindler, Xiao-Zhe Huang, May Chu, Ted L. Hadfield, and Michael Dobson

Yersinia pestis as an Emerged Pathogen: What Lessons Can Be Learned?
Luther E. Lindler

IV. Diagnostic Development for Biowarfare Agents

Requirements for Biological Threat Identification Systems
Erik A. Henchal and George V. Ludwig

DNA-Based Diagnostic Tests for Detection and Identification of Biological Weapons
Luther E. Lindler, David Norwood, Michael Dobson, and Ted L. Hadfield

Concepts for the Development of Immunodiagnostic Assays for Detection and Diagnosis of Biothreat Agents
George V. Ludwig, Cynthia A. Rossi, and Robert L. Bull

Index

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