Biology of Extracellular Molecular Chaperones / Edition 1

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Overview

The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses.

Since the promulgation of the ‘molecular chaperone’ concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular chaperones as folding proteins went hand-in-hand with their recognition as potent immunogens in microbial infection. It was subsequently shown that administration of molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer.

More recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro- or anti-inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer.

This is the first book bringing leading researchers in this field together to review and discuss:

  • our current knowledge of cell stress response and molecular chaperones
  • the changing paradigms of protein trafficking and function
  • cell stress proteins as immunomodulators and pro- and anti-inflammatory signalling molecules
  • the role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents.

The Biology of Extracellular Molecular Chaperones is of particular interest to immunologists, cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes, rheumatoid arthritis and other inflammatory diseases.

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Editorial Reviews

From The Critics
Reviewer: Marion C. Cohen, PhD (SUNY Downstate Medical Center)
Description: The Novartis Foundation (originally the CIBA Foundation) was established to promote the study of science. Each book in the Novartis Foundation Symposium series represents the proceedings of an international meeting, featuring the papers and discussions that were presented. Because this volume is the output of a symposium on extracellular molecular chaperones, it is both an update and a new collection.
Purpose: These meetings have always been of very high quality, which is reflected in the publications. In this case, the topic is the mechanism of action of extracellular molecular chaperones and their application to therapy. This is an area of increasing attention and up-to-date information is always welcome. The papers themselves provided a springboard to further questions at the meeting, and the chair recounts some of these in the introduction.
Audience: The book is written primarily for researchers in the field. It would also be of use to anyone who needs an advanced level of information about chaperones. Both the editors and the authors who participated in the meeting are experts in the field.
Features: A number of different questions about extracellular chaperones are covered, ranging from their regulation and how they get out of the cell to their pro- and anti-inflammatory roles. In addition to the papers, the discussions following each one are also presented so that readers who did not attend the meeting can consider the issues that were raised. The format of the book is a standard proceedings type of publication. The meeting was held in June 2007, so the references are fairly current.
Assessment: This is a useful addition to the literature on chaperones, but, unfortunately, it is an expensive book for an individual to purchase. However, it provides an excellent source of information for anyone who needs more than just basic knowledge about this area of biology.
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Product Details

  • ISBN-13: 9780470723333
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 5/16/2008
  • Series: Novartis Foundation Symposia Series
  • Edition number: 1
  • Pages: 248
  • Product dimensions: 6.30 (w) x 9.11 (h) x 0.68 (d)

Table of Contents

Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5–7 June 2007.

Editors: Derek J. Chadwick (Organizer) and Jamie Goode.

This symposium is based on a proposal made by Brian Henderson, R. John Ellis and A. Graham Pockley

Péter Csermely Chair's introduction.

Jodie Haak and Kevin C. Kregel 1962–2007: a cell stress odyssey.

Discussion.

Peter A. Lund and R. John Ellis The chaperone function: meanings and myths.

Discussion.

Péter Csermely, Tamás Korcsmáros, István A. Kovács, Máté S. Szalay and Csaba Soti Systems biology of molecular chaperone networks.

Discussion.

Radhey S. Gupta , Nallur B. Ramachandra, Timothy Bowes and Bhag Singh Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10.

Discussion.

Martha Triantafilou, Daniel Sawyer, Abdiaziz Nor, Emmanouil Vakakis and Kathy Triantafilou Cell surface molecular chaperones as endogenous modulators of the innate immune response.

Discussion.

A. Graham Pockley and Gabriele Multhoff Cell stress proteins in extracellular fluids: friend or foe?

Discussion.

Francisco J. Quintana and Irun R. Cohen HSP60 speaks to the immune system in many voices.

Discussion.

Stuart K. Calderwood, Jianlin Gong, Jimmy R. Theriault, Salamatu S. Mambula and Philip J. Gray Jnr Cell stress proteins: novel immunotherapeutics.

Discussion.

General discussion.

Brian Henderson Cell stress proteins as modulators of bacteria–host interactions.

Discussion.

Anthony R. M. Coates, Ana Cehovin and Yanmin Hu Chaperonin 60 and macrophage activation.

Discussion.

Alexzander Asea Hsp70: a chaperokine.

Discussion.

Hajime Nakamura Extracellular functions of thioredoxin.

Discussion.

Carol L. Miller-Graziano, Asit De, Krzysztof Laudanski, Tara Herrmann and Sanjukta Bandyopadhyay HSP27: an anti-inflammatory and immunomodulatory stress protein acting to dampen immune function.

Discussion.

Gabriel S. Panayi and Valerie M. Corrigall BiP, an anti-inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis.

Discussion.

Final discussion.

Index of contributors.

Subject index.

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