The Biology of the Autistic Syndromes / Edition 3

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Autism is not a single disease but a syndrome of different diseases. In this completely reworked and updated third edition, two world authorities, Christopher Gillberg and Mary Coleman, address the difficulties this presents for clinical diagnosis with diagnostic aids and clear guidelines for medical evaluation. Epidemiology, neuropsychological studies and behavior complexes, such as self-injury, are reviewed in detail, and the authors give a detailed explanation of what is known about the molecular biology and genetics of autism. Epilepsy and electrophysiological studies are also covered, as well as biochemistry, endocrinology, immunology, brain imaging and neuropathology. The available medical therapies are reviewed, along with an update on what is known about other interventions, such as psychoeducational and behavioral modification procedures. The book concludes with an integration of current knowledge from diverse fields. This is an essential text for clinicians and will also be of interest to parents of autistic children.

This book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Shiraz Butt, MD (Rush University Medical Center)
Description: This book provides a comprehensive update on the recent advances in the field of autism with a focus on the neurobiology of this disorder.
Purpose: The purpose is to provide an understanding of autism as a syndrome caused by a variety of pathophysiological processes. These are extremely worthy objectives and a book like this helps further our understanding of autism. The authors are able to clarify the diagnostic issues in the autistic spectrum disorders.
Audience: This book is written for physicians who diagnose and treat patients with an autistic disorder. It is intended for psychiatrists, neurologists, developmental pediatricians, and neuropsychiatrists. The author has done extensive research in this area with numerous publications.
Features: This book provides an extensive overview of the clinical diagnosis of autism There is an attempt to differentiate classic autism from related conditions. The course of the illness through various developmental stages is laid out. The book highlights the neurobiology of autism focusing on the empirical evidence. The genetic research is presented very well and a neurological model is adopted to identify a lesion responsible for causing autism. The chapter on double syndromes, which describes patients with a dual diagnosis of a known medical syndrome plus an autistic syndrome, is very useful. The review of brain imaging research is extremely thorough. There is a separate chapter on Asperger's Syndrome with an attempt to clarify the controversial issues in diagnosis.
Assessment: The field of autism has seen an increase in research and literature in the last few decades. This book is an updated edition providing a detailed account of the latest research in the neuroimaging, genetics, and biochemistry of autism. It also addresses the diagnostic issues in autistic disorders, which is a matter of much controversy. The authors view autism as a neurodevelopmental process with a neurobiological insult to the brain occurring very early on in development, very likely in fetal life. The field of autism and its related disorders is changing so rapidly that an updated edition has come at the right time. The relationship of autism to known medical diseases and genetic syndromes is very well covered. The authors view autism as a syndrome and not as a single disease entity emphasizing the critical role of an individualized evaluation in each unique case.
Margery R. Johnson
This is a second edition of a book by a child psychiatrist and a pediatric neurologist. It offers a comprehensive overview of the pathophysiology and clinical presentation of the autistic syndromes, emphasizing the complexity and heterogeneity of this spectrum of disorders. This book offers a very readable overview, covering all aspects of the biology of autism. It provides both a historical overview of the disorders and an update on current research and clinical treatment. This book would be appropriate for the practicing child psychiatrist, child neurologist, or developmental psychologist, even one with considerable experience with autism. It is also written so clearly that the parent of an autistic child might benefit from reading parts of the book. This book contains numerous black-and-white photographs of children with autism. Some of the photos are merely interesting and pleasant to look at, whereas others are more specifically instructive and illustrative of specific syndromes or chromosomal abnormalities associated with autism. In either case, they are a nice contribution to the book. The tables that address diagnostic criteria or differential diagnosis are especially helpful, clear, and complete. This is a very complete, well-written overview that presents a balanced discussion of a heterogeneous neuropsychiatric disorder. It would be of interest to both the beginner and the seasoned practitioner. It includes both classic and up-to-date references and presents an excellent overview of the state of knowledge in the field of autism.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781898683223
  • Publisher: Wiley
  • Publication date: 1/18/2000
  • Series: Clinics in Developmental Medicine Series, #153
  • Edition description: REV
  • Edition number: 3
  • Pages: 340
  • Product dimensions: 7.00 (w) x 9.80 (h) x 1.15 (d)

Table of Contents

Preface; 1. Introduction; 2. Clinical diagnosis of autism; 3. Diagnosis in infancy; 4. Clinical course in childhood and adolescence; 5. Adults with autism; 6. Asperger syndrome; 7. Behavior complexes seen in individuals with autism; 8. Epidemiology of autism; 9. Neuropsychological studies; 10. The disease entities of autism; 11. The double syndromes; 12. Seizures and electrophysiological studies; 13. Biochemistry, endocrinology and immunology; 14. Brain imaging and neuropathological studies; 15. The genetics of autism; 16. The medical work-up; 17. Medical therapies; 18. Other interventions - psychoeducational and behavioral modification procedures; 19. The neurology of autism; Glossary; Appendices; Index.

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