The Biology of Tumors / Edition 1

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Editorial Reviews

The June 1997 symposium focused on the genetic mechanisms underlying heterogeneity of tumor cell populations and tumor cell differentiation, on interactions between tumor cells and cells of host defenses, and the mechanisms of angiogenesis. Some of the 23 presentations address issues related to phenomena concerned with cell regulation and cell interactions as determined by activated genes through the appropriate and timely mediation of gene products. Methodologies that allow scientists to measure differentially genes and gene products and thus validate many of the mechanisms of control currently proposed are considered, as are the molecular basis of tumor recognition by the immune system, interactions between cells, and molecular mechanisms of cell regulation as they are affected by or implemented through these interactions. The molecular and cellular mechanisms of tumor vascularization is also discussed. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780306459320
  • Publisher: Springer US
  • Publication date: 11/1/2007
  • Series: Pezcoller Foundation Symposia Series, #9
  • Edition description: 1998
  • Edition number: 1
  • Pages: 351
  • Product dimensions: 9.21 (w) x 6.14 (h) x 0.88 (d)

Table of Contents

1.The Role for ink4a in Melanoma Pathogenesis: One Gene, Two Products, Multiple Pathways; J. Pomerantz, et al. 2. Identification and Characterization of collaborating Oncogenes in Compound Mutant Mice; A. Berns, et al. 3. The Transcription Factor B-Myb Is Phosphorylated and Activated by Cyclin A/Cdk2; O. Bartsch, et al. 4. Distinct Dynamics and Regulatory Signal Transduction of Cell Migration: Lessons from Dendritic Cells, Tumor Cells and T Lymphocytes; F. Entschladen, et al. 5. Genomic Instability in Sporadic Colorectal Cancer: A Destabilized Genome Producing Accelerated Cellular Evolution as the Fundamental Nature of Cancer; G.R. Anderson, et al. 6. APC and the Early Events of Colon Cancer; R.L. White. 7. Genome Scanning and Gene Discovery in Breast and Ovarian Cancer; J.W. Gray, et al. 8. Failure of Tumor Immunity Resulting from Inaccessibility of Activated Lymphocytes to Solid Tumors: The Possible Role of the Endothelium; R. Ganss, D. Hanahan. 9. Deciphering Molecular Circuitry Using High-Density DNA Arrays; D.H. Mack, et al. 10. Use of cDNA Microarrays to Assess DNA Gene Expression Patterns in Cancer; P.S. Meltzer, et al. 11. Eh, a Novel Protein: Protein Interaction Domain; M. Doria, et al. 12 Additional Chapters. Index.

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