Table of Contents
Preface vii
Contributors ix
1. Antioxidant Activity and Oxidative Stress: An Overview 3Kyung-Jin Yeum, Robert M. Russell, and Giancarlo Aldini
2. Enzymatic Antioxidant Defenses 21Sayuri Miyamoto, Hirofumi Arai, and Junji Terao
3. Antioxidants as Biomarkers of Oxidative Stress 35Ikuyo Ichi and Shosuke Kojo
4. LDL Oxidation as a Biomarker of Antioxidant Status 51Mohsen Meydani, EunHee Kong, and Ashley Knight
5. The Isoprostanes: Accurate Markers and Potent Mediators of Oxidant Injury in Vivo 65Joshua D. Brooks, Brian E. Cox, Klarissa D. Hardy, Stephanie C. Sanchez, Sonia Tourino, Tyler H. Koestner, Jocelyn R. Hyman-Howard, and Ginger L. Milne
6. Hydroxyoctadecadienoic Acid (HODE) as a Marker of Linoleic Acid Oxidation 85Yasukazu Yoshida and Etsuo Niki
7. Oxysterols: Potential Biomarkers of Oxidative Stress 99Luigi Iuliano and Ulf Diczfalusy
8. Lipid Peroxidation Originating α, β-unsaturated Aldehydes and Their Metabolites as Biomarkers 117Françoise Guéraud
9. Oxidative Modifi cation of Proteins: An Overview 137Paul J. Thornalley and Naila Rabbani
10. Immunochemical Detection of Lipid Peroxidation-specific Epitopes 157Koji Uchida
11. Mass Spectrometric Strategies for Identification and Characterization of Carbonylated Peptides and Proteins 173Marina Carini and Marica Orioli
12. Nitrotyrosine: Quantitative Analysis, Mapping in Proteins, and Biological Significance 199José M. Souza, Silvina Bartesaghi, Gonzalo Peluffo, and Rafael Radi
13. Ubiquitin Conjugates: A Sensitive Marker of Oxidative Stress 219Fu Shang and Allen Taylor
14. Covalent Modifications of Albumin Cys34 as a Biomarker of Mild Oxidative Stress 229Giancarlo Aldini, Kyung-Jin Yeum, and Giulio Vistoli
15. Protein S-glutathionylation and S-cysteinylation 243Graziano Colombo, Aldo Milzani, Roberto Colombo, and Isabella Dalle-Donne
16. DNA Oxidation, Antioxidant Effects, and DNA Repair Measured with the Comet Assay 261Mária Dušinská and Andrew R. Collins
17. Hydroxylated Nucleotides: Measurement and Utility as Biomarkers for DNA Damage, Oxidative Stress, and Antioxidant Efficacy 283Phyllis E. Bowen
18. Exocyclic DNA Adducts as Biomarkers of Antioxidant Defense and Oxidative Stress 319Roger W.L. Godschalk
Index 333