Biomarkers in Breast Cancer / Edition 1

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Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

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Editorial Reviews

Doody's Review Service
Reviewer: Mary E. Cianfrocca, DO (Northwestern University Feinberg School of Medicine)
Description: This is an overview of the major predictive and prognostic biomarkers in breast cancer.
Purpose: The objectives of the book, to review the major advances in the application of molecular methodology as well as the state-of-the-art of conventional prognostic and predictive biomarkers in breast cancer, were met. These are very worthy objectives as this is a rapidly advancing field that has the potential to drastically change the way we approach the treatment of breast cancer in the future.
Audience: The editors intended the book to be used by laboratory and clinical investigators, but it is also a useful review of the subject for clinicians. The editors and contributors are all credible authorities in the field.
Features: The first three chapters cover study design and guidelines for validation studies of new biomarkers while the next two chapters cover gene expression profiling with DNA microarrays and assays for gene amplification. Subsequent chapters cover individual biomarkers in detail. The chapters are well written and comprehensive. Chapters on erb-B2, for example, provide a detailed examination of the predictive value of this marker as well as its usefulness as a therapeutic target.
Assessment: This book will be very useful to the intended target population of researchers as well as to a broader audience. The use of biomarkers in breast cancer shows great promise in significantly influencing our future treatment of breast cancer. A well-written review of the topic such as this one would therefore also be very valuable to clinicians and physicians in training.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9781617374364
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 12/1/2010
  • Series: Cancer Drug Discovery and Development Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2006
  • Edition number: 1
  • Pages: 342
  • Product dimensions: 9.00 (w) x 6.00 (h) x 0.79 (d)

Table of Contents

Part I. General Topics

Guidelines for the Design of Clinical Studies for the Development and Validation of Therapeutically Relevant Biomarkers and Biomarker-Based Classification Systems
Richard M. Simon

Analytical Aspects of Biomarker Immunoassays in Cancer Research
Fred C. G. J. Sweep, Chris M. G. Thomas, and Manfred Schmitt

Tissue Microarrays: State of the Art, Pitfalls, and Promises
Chungyeul Kim and Soonmyung Paik

Part II. Assays for Gene Expression and Post-Translational Protein Abnormalities

Gene Expression Profiling with DNA Microarrays: Revolutionary Tools to Help Diagnosis, Prognosis, Treatment Guidance, and Drug Discovery
Michele De Bortoli and Nicoletta Biglia

Part III. Assays for DNA Abnormalities

Assays for Gene Amplification: State of the Art, Pitfalls, and Promises
Chungyeul Kim, Yongkuk Song, and Soonmyung Paik

Part IV. Tissue Predictive Biomarkers

Cell Kinetics
Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori

Urokinase-Type Plasminogen Activator and PAI-1: Validated Prognostic Factors for Breast Cancer
Michael J. Duffy

Predictive Value of c-erb-B2 for Endocrine Therapy and Chemotherapy in Breast Cancer
Vered Stearns

erb-B2 as a Therapeutic Target
Robert Mass

The Epidermal Growth Factor Receptor Pathway as a Selective Molecular-Targeted Treatment in Human Breast Cancer
Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora

p53 as a Prognostic and Predictive Indicator
Daniela Kandioler and Raimund Jakesz

Part V. Predictive Biomarkers in Body Fluids

Occult Metastatic Cells in Breast Cancer Patients: State of the Art, Pitfalls, and Promises
Stephan Braun, Julia Seeber, and Christian Marth

Circulating HER2/neu: Clinical Utility
Allan Lipton, Laurence Demers, Kim Leitzel, Suhail M. Ali, Rainer Neumann, Christopher P. Price, and Walter P. Carney

Circulating Vascular Endothelial Growth Factor: Methods, Prognostic Significance, and Potential Application for Antiangiogenic Therapy
Roberta Sarmiento, Roberta Franceschini, Sabrina Meo, Massimo Gion, Raffele Longo, and Giampietro Gasparini

Detection of Early Tumor Dissemination in Patients with Breast Cancer
Debra Hawes and Richard J. Cote

Part VI. Future Directions

New Technologies/New Markers/New Challenges
Daniel F. Hayes and Giampietro Gasparini


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