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Doody's Review ServiceReviewer: Mary E. Cianfrocca, DO (Northwestern University Feinberg School of Medicine)
Description: This is an overview of the major predictive and prognostic biomarkers in breast cancer.
Purpose: The objectives of the book, to review the major advances in the application of molecular methodology as well as the state-of-the-art of conventional prognostic and predictive biomarkers in breast cancer, were met. These are very worthy objectives as this is a rapidly advancing field that has the potential to drastically change the way we approach the treatment of breast cancer in the future.
Audience: The editors intended the book to be used by laboratory and clinical investigators, but it is also a useful review of the subject for clinicians. The editors and contributors are all credible authorities in the field.
Features: The first three chapters cover study design and guidelines for validation studies of new biomarkers while the next two chapters cover gene expression profiling with DNA microarrays and assays for gene amplification. Subsequent chapters cover individual biomarkers in detail. The chapters are well written and comprehensive. Chapters on erb-B2, for example, provide a detailed examination of the predictive value of this marker as well as its usefulness as a therapeutic target.
Assessment: This book will be very useful to the intended target population of researchers as well as to a broader audience. The use of biomarkers in breast cancer shows great promise in significantly influencing our future treatment of breast cancer. A well-written review of the topic such as this one would therefore also be very valuable to clinicians and physicians in training.